Abstract
Recent evidence suggests that human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) patients have better survival than HPV-negative patients. However, it is unclear if similar patterns for survival exist across different tumor sites, and whether HPV-associated prognosis is modified by type of treatment. We prospectively tested 222 histologically confirmed HNSCC primary tumors for HPV DNA by PCR and HPV E6/E7 RNA by RT-PCR prior to treatment at a large urban health center. Cox proportional hazard ratio models were constructed to assess HPV-associated differences in overall and disease-specific survival adjusting for clinical and demographic covariates. HPV detection varied significantly by primary HNSCC tumor site, from 35 % for oropharynx, to 25 % for hypopharynx, 5 % for larynx, and 3 % for oral cavity (p < 0.0001), with HPV16 accounting for the majority (95 %) of HPV-positive tumors. The hazard-risk of overall and disease-specific death comparing HPV16-positive versus negative oropharyngeal HNSCC was reduced by 74 and 89 %, respectively (p values < 0.05), and was independent of other prognostic indicators; no statistically significant changes in outcomes were observed for non-oropharyngeal HNSCC sites. Prediction of overall survival was better with combined DNA and RNA HPV16 positive PCR detection. There was no difference in HPV16-associated survival whether patients received either surgery or (chemo)radiotherapy as their initial treatment modality. Improved HPV-associated HNSCC survival is limited to patients with oropharyngeal primaries. No selective treatment advantage is observed for HPV-positive tumors, although clinical trials are needed to evaluate which treatment modalities provide the most benefit for HPV-positive HNSCC.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 77-87 |
| Number of pages | 11 |
| Journal | Head and Neck Pathology |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 1 2014 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
- Otorhinolaryngology
- Oncology
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Human Papillomavirus-Associated Head and Neck Squamous Cell Carcinoma Survival : A Comparison by Tumor Site and Initial Treatment. / Salazar, Christian R.; Smith, Richard V.; Garg, Madhur K.; Haigentz, Missak; Schiff, Bradley A.; Kawachi, Nicole; Anayannis, Nicole; Belbin, Thomas J.; Prystowsky, Michael B.; Burk, Robert D.; Schlecht, Nicolas F.
In: Head and Neck Pathology, Vol. 8, No. 1, 01.03.2014, p. 77-87.Research output: Contribution to journal › Article
TY - JOUR
T1 - Human Papillomavirus-Associated Head and Neck Squamous Cell Carcinoma Survival
T2 - A Comparison by Tumor Site and Initial Treatment
AU - Salazar, Christian R.
AU - Smith, Richard V.
AU - Garg, Madhur K.
AU - Haigentz, Missak
AU - Schiff, Bradley A.
AU - Kawachi, Nicole
AU - Anayannis, Nicole
AU - Belbin, Thomas J.
AU - Prystowsky, Michael B.
AU - Burk, Robert D.
AU - Schlecht, Nicolas F.
PY - 2014/3/1
Y1 - 2014/3/1
N2 - Recent evidence suggests that human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) patients have better survival than HPV-negative patients. However, it is unclear if similar patterns for survival exist across different tumor sites, and whether HPV-associated prognosis is modified by type of treatment. We prospectively tested 222 histologically confirmed HNSCC primary tumors for HPV DNA by PCR and HPV E6/E7 RNA by RT-PCR prior to treatment at a large urban health center. Cox proportional hazard ratio models were constructed to assess HPV-associated differences in overall and disease-specific survival adjusting for clinical and demographic covariates. HPV detection varied significantly by primary HNSCC tumor site, from 35 % for oropharynx, to 25 % for hypopharynx, 5 % for larynx, and 3 % for oral cavity (p < 0.0001), with HPV16 accounting for the majority (95 %) of HPV-positive tumors. The hazard-risk of overall and disease-specific death comparing HPV16-positive versus negative oropharyngeal HNSCC was reduced by 74 and 89 %, respectively (p values < 0.05), and was independent of other prognostic indicators; no statistically significant changes in outcomes were observed for non-oropharyngeal HNSCC sites. Prediction of overall survival was better with combined DNA and RNA HPV16 positive PCR detection. There was no difference in HPV16-associated survival whether patients received either surgery or (chemo)radiotherapy as their initial treatment modality. Improved HPV-associated HNSCC survival is limited to patients with oropharyngeal primaries. No selective treatment advantage is observed for HPV-positive tumors, although clinical trials are needed to evaluate which treatment modalities provide the most benefit for HPV-positive HNSCC.
AB - Recent evidence suggests that human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) patients have better survival than HPV-negative patients. However, it is unclear if similar patterns for survival exist across different tumor sites, and whether HPV-associated prognosis is modified by type of treatment. We prospectively tested 222 histologically confirmed HNSCC primary tumors for HPV DNA by PCR and HPV E6/E7 RNA by RT-PCR prior to treatment at a large urban health center. Cox proportional hazard ratio models were constructed to assess HPV-associated differences in overall and disease-specific survival adjusting for clinical and demographic covariates. HPV detection varied significantly by primary HNSCC tumor site, from 35 % for oropharynx, to 25 % for hypopharynx, 5 % for larynx, and 3 % for oral cavity (p < 0.0001), with HPV16 accounting for the majority (95 %) of HPV-positive tumors. The hazard-risk of overall and disease-specific death comparing HPV16-positive versus negative oropharyngeal HNSCC was reduced by 74 and 89 %, respectively (p values < 0.05), and was independent of other prognostic indicators; no statistically significant changes in outcomes were observed for non-oropharyngeal HNSCC sites. Prediction of overall survival was better with combined DNA and RNA HPV16 positive PCR detection. There was no difference in HPV16-associated survival whether patients received either surgery or (chemo)radiotherapy as their initial treatment modality. Improved HPV-associated HNSCC survival is limited to patients with oropharyngeal primaries. No selective treatment advantage is observed for HPV-positive tumors, although clinical trials are needed to evaluate which treatment modalities provide the most benefit for HPV-positive HNSCC.
UR - http://www.scopus.com/inward/record.url?scp=84897621681&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897621681&partnerID=8YFLogxK
U2 - 10.1007/s12105-013-0486-4
DO - 10.1007/s12105-013-0486-4
M3 - Article
C2 - 24002971
AN - SCOPUS:84897621681
VL - 8
SP - 77
EP - 87
JO - Head and Neck Pathology
JF - Head and Neck Pathology
SN - 1936-055X
IS - 1
ER -