Human greater saphenous vein

Histologic and ultrastructural variation

M. L. Marin, F. J. Veith, T. F. Panetta, Clifford Sales, K. R. Wengerter, R. E. Gordon

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

This study describes the varied histologic features and ultrastructure of human saphenous veins obtained from patients undergoing infrainguinal arterial reconstruction. Portions of 30 remnant veins were fixed at arterial pressure (100 mmHg). Vein specimens were obtained from 13 men and 17 women, with a mean age of 70.2 years. Ten veins (33%) were from diabetic patients. Samples of fixed veins were prepared for light and electron microscopy. The luminal surface contained valves and redundant intimal folds at the site of ligated side branches. Microvalves were present at the orifices of several 1-mm vein tributaries. The endothelial cells lining the intima were often discontinuous and were aligned in a variable pattern. The thicknesses of the vein walls varied from 20 to 360 μm, with increased connective tissue matrix in the intima and medial layers of thick-walled veins. Some 10% of the veins demonstrated spindle cells in the intima; these cells had a smooth muscle cell phenotype and varied with respect to the degree of cellular differentiation. Regions of vein wall calcification were occasionally seen and were always present in association with a thickened vein intima. Variations in the structure of the saphenous vein from patients undergoing bypass surgery are common. The relationship between altered saphenous vein morphology and subsequent vein graft stenosis needs to be defined.

Original languageEnglish (US)
Pages (from-to)56-62
Number of pages7
JournalVascular
Volume2
Issue number1
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Saphenous Vein
Veins
Tunica Intima
Connective Tissue
Smooth Muscle Myocytes
Electron Microscopy
Arterial Pressure
Pathologic Constriction
Endothelial Cells
Transplants
Phenotype
Light

All Science Journal Classification (ASJC) codes

  • Surgery
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Marin, M. L., Veith, F. J., Panetta, T. F., Sales, C., Wengerter, K. R., & Gordon, R. E. (1994). Human greater saphenous vein: Histologic and ultrastructural variation. Vascular, 2(1), 56-62. https://doi.org/10.1177/096721099400200113
Marin, M. L. ; Veith, F. J. ; Panetta, T. F. ; Sales, Clifford ; Wengerter, K. R. ; Gordon, R. E. / Human greater saphenous vein : Histologic and ultrastructural variation. In: Vascular. 1994 ; Vol. 2, No. 1. pp. 56-62.
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Marin, ML, Veith, FJ, Panetta, TF, Sales, C, Wengerter, KR & Gordon, RE 1994, 'Human greater saphenous vein: Histologic and ultrastructural variation', Vascular, vol. 2, no. 1, pp. 56-62. https://doi.org/10.1177/096721099400200113

Human greater saphenous vein : Histologic and ultrastructural variation. / Marin, M. L.; Veith, F. J.; Panetta, T. F.; Sales, Clifford; Wengerter, K. R.; Gordon, R. E.

In: Vascular, Vol. 2, No. 1, 01.01.1994, p. 56-62.

Research output: Contribution to journalArticle

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