Histologic Correlates of Clinical and Endoscopic Severity in Children Newly Diagnosed with Ulcerative Colitis

Brendan Boyle, Margaret H. Collins, Zhu Wang, David MacK, Anne Griffiths, Cary Sauer, James Markowitz, Neal Leleiko, David Keljo, Joel Rosh, Susan S. Baker, Marian Pfefferkorn, Melvin Heyman, Ashish Patel, Robert Baldassano, Joshua Noe, Paul Rufo, Subra Kugathasan, Thomas Walters, Lee Denson & 1 others Jeffrey Hyams

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

To characterize rectal histology in an inception cohort of children newly diagnosed with ulcerative colitis (UC) and to explore its relationship with clinical indices of disease severity. The PROTECT (Predicting Response to Standardized Pediatric Colitis Therapy) Study enrolled children 17 years of age and younger newly diagnosed with UC. Baseline rectal biopsies were evaluated for acute and chronic inflammation, eosinophilic inflammation (peak eosinophil count > 32 eosinophils/high powered field, eosinophilic cryptitis or abscesses), and architectural/nonarchitectural chronic changes. Correlation with clinical indices including Mayo endoscopy subscore and Pediatric Ulcerative Colitis Activity Index was performed. Rectal biopsies from 369 patients (mean age, 12.9±3.1 y, 50% female) were reviewed. Cryptitis was found in 89%, crypt abscesses in 25%, and eosinophilic inflammation in 58%. Crypt distortion/atrophy was present in 98% of specimens. Higher grades of acute and chronic inflammation were associated with the presence of basal plasmacytosis (P<0.0001), basal lymphoid aggregates (P<0.0001), and surface villiform changes (P<0.0001). A severe Mayo endoscopy subscore was most common among those with severe acute and chronic inflammation, although this relationship was not linear. Severe Pediatric Ulcerative Colitis Activity Index scores were associated with the absence of or only mild eosinophilic inflammation (<32 eosinophils/high powered field) (P<0.03) and the presence of surface villiform changes (P<0.005). Acute and chronic inflammation, eosinophilic inflammation and chronic changes are common in children newly diagnosed with UC. The clinical and biological implication of low to absent eosinophilic inflammation and the presence of surface villiform changes requires further study.

Original languageEnglish (US)
Pages (from-to)1491-1498
Number of pages8
JournalAmerican Journal of Surgical Pathology
Volume41
Issue number11
DOIs
StatePublished - Jan 1 2017

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Ulcerative Colitis
Inflammation
Eosinophils
Abscess
Endoscopy
Biopsy
Colitis
Atrophy
Histology
Pediatrics

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Boyle, Brendan ; Collins, Margaret H. ; Wang, Zhu ; MacK, David ; Griffiths, Anne ; Sauer, Cary ; Markowitz, James ; Leleiko, Neal ; Keljo, David ; Rosh, Joel ; Baker, Susan S. ; Pfefferkorn, Marian ; Heyman, Melvin ; Patel, Ashish ; Baldassano, Robert ; Noe, Joshua ; Rufo, Paul ; Kugathasan, Subra ; Walters, Thomas ; Denson, Lee ; Hyams, Jeffrey. / Histologic Correlates of Clinical and Endoscopic Severity in Children Newly Diagnosed with Ulcerative Colitis. In: American Journal of Surgical Pathology. 2017 ; Vol. 41, No. 11. pp. 1491-1498.
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abstract = "To characterize rectal histology in an inception cohort of children newly diagnosed with ulcerative colitis (UC) and to explore its relationship with clinical indices of disease severity. The PROTECT (Predicting Response to Standardized Pediatric Colitis Therapy) Study enrolled children 17 years of age and younger newly diagnosed with UC. Baseline rectal biopsies were evaluated for acute and chronic inflammation, eosinophilic inflammation (peak eosinophil count > 32 eosinophils/high powered field, eosinophilic cryptitis or abscesses), and architectural/nonarchitectural chronic changes. Correlation with clinical indices including Mayo endoscopy subscore and Pediatric Ulcerative Colitis Activity Index was performed. Rectal biopsies from 369 patients (mean age, 12.9±3.1 y, 50{\%} female) were reviewed. Cryptitis was found in 89{\%}, crypt abscesses in 25{\%}, and eosinophilic inflammation in 58{\%}. Crypt distortion/atrophy was present in 98{\%} of specimens. Higher grades of acute and chronic inflammation were associated with the presence of basal plasmacytosis (P<0.0001), basal lymphoid aggregates (P<0.0001), and surface villiform changes (P<0.0001). A severe Mayo endoscopy subscore was most common among those with severe acute and chronic inflammation, although this relationship was not linear. Severe Pediatric Ulcerative Colitis Activity Index scores were associated with the absence of or only mild eosinophilic inflammation (<32 eosinophils/high powered field) (P<0.03) and the presence of surface villiform changes (P<0.005). Acute and chronic inflammation, eosinophilic inflammation and chronic changes are common in children newly diagnosed with UC. The clinical and biological implication of low to absent eosinophilic inflammation and the presence of surface villiform changes requires further study.",
author = "Brendan Boyle and Collins, {Margaret H.} and Zhu Wang and David MacK and Anne Griffiths and Cary Sauer and James Markowitz and Neal Leleiko and David Keljo and Joel Rosh and Baker, {Susan S.} and Marian Pfefferkorn and Melvin Heyman and Ashish Patel and Robert Baldassano and Joshua Noe and Paul Rufo and Subra Kugathasan and Thomas Walters and Lee Denson and Jeffrey Hyams",
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Boyle, B, Collins, MH, Wang, Z, MacK, D, Griffiths, A, Sauer, C, Markowitz, J, Leleiko, N, Keljo, D, Rosh, J, Baker, SS, Pfefferkorn, M, Heyman, M, Patel, A, Baldassano, R, Noe, J, Rufo, P, Kugathasan, S, Walters, T, Denson, L & Hyams, J 2017, 'Histologic Correlates of Clinical and Endoscopic Severity in Children Newly Diagnosed with Ulcerative Colitis', American Journal of Surgical Pathology, vol. 41, no. 11, pp. 1491-1498. https://doi.org/10.1097/PAS.0000000000000939

Histologic Correlates of Clinical and Endoscopic Severity in Children Newly Diagnosed with Ulcerative Colitis. / Boyle, Brendan; Collins, Margaret H.; Wang, Zhu; MacK, David; Griffiths, Anne; Sauer, Cary; Markowitz, James; Leleiko, Neal; Keljo, David; Rosh, Joel; Baker, Susan S.; Pfefferkorn, Marian; Heyman, Melvin; Patel, Ashish; Baldassano, Robert; Noe, Joshua; Rufo, Paul; Kugathasan, Subra; Walters, Thomas; Denson, Lee; Hyams, Jeffrey.

In: American Journal of Surgical Pathology, Vol. 41, No. 11, 01.01.2017, p. 1491-1498.

Research output: Contribution to journalArticle

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AU - Boyle, Brendan

AU - Collins, Margaret H.

AU - Wang, Zhu

AU - MacK, David

AU - Griffiths, Anne

AU - Sauer, Cary

AU - Markowitz, James

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AU - Keljo, David

AU - Rosh, Joel

AU - Baker, Susan S.

AU - Pfefferkorn, Marian

AU - Heyman, Melvin

AU - Patel, Ashish

AU - Baldassano, Robert

AU - Noe, Joshua

AU - Rufo, Paul

AU - Kugathasan, Subra

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AU - Denson, Lee

AU - Hyams, Jeffrey

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