Health-related quality of life in the first year after a diagnosis of pediatric inflammatory bowel disease

Anthony R. Otley, Anne M. Griffiths, Sandra Hale, Subra Kugathasan, Marian Pfefferkorn, Adam Mezoff, Joel Rosh, Vasundhara Tolia, James Markowitz, David Mack, Maria Oliva-Hemker, Robert Wyllie, Robert Rothbaum, Athos Bousvaros, J. Fernando Del Rosario, Jonathan Evans, Wade Blanchard, Jeffrey Hyams

Research output: Contribution to journalArticle

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Abstract

BACKGROUND AND AIMS: Assessment of health-related quality of life (HRQOL) is of increasing importance in the evaluation of new therapies for inflammatory bowel disease (IBD). Available data concerning HRQOL in pediatric patients are sparse and uniformly cross-sectional. The aim of this study was to describe HRQOL and influential factors in newly diagnosed pediatric patients with Crohn's disease and ulcerative colitis during the first 12 months after diagnosis. MATERIALS AND METHODS: Participants were drawn from a large, prospectively derived observational IBD registry of pediatric patients studied through 18 U.S. and Canadian centers. Patients who had completed a baseline IMPACT questionnaire and for whom there were 12 months of follow-up data available were included. In addition to description of cohort, factors that were believed to influence HLQOL were assessed during the course of the year from diagnosis. RESULTS: Two hundred eighteen children met inclusion criteria (77% Crohn's disease, 23 % ulcerative colitis, mean age 12.7 ± 1.9 years). Mean total IMPACT score at baseline was 154, 181 at 6 months, and 191 at 1 year (possible range 0-238, with increasing scores representing better quality of life). Repeated measures analysis showed that age and disease severity significantly negatively affected the IMPACT scores during the course of the year. CONCLUSIONS: In this large prospective pediatric IBD cohort, significant improvement in HRQOL is noted during the year from diagnosis. Mean IMPACT scores varied significantly depending on the disease severity and also decreased with increasing age.

Original languageEnglish (US)
Pages (from-to)684-691
Number of pages8
JournalInflammatory bowel diseases
Volume12
Issue number8
DOIs
StatePublished - Aug 1 2006
Externally publishedYes

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Inflammatory Bowel Diseases
Quality of Life
Pediatrics
Ulcerative Colitis
Crohn Disease
Registries
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Gastroenterology

Cite this

Otley, A. R., Griffiths, A. M., Hale, S., Kugathasan, S., Pfefferkorn, M., Mezoff, A., ... Hyams, J. (2006). Health-related quality of life in the first year after a diagnosis of pediatric inflammatory bowel disease. Inflammatory bowel diseases, 12(8), 684-691. https://doi.org/10.1097/00054725-200608000-00003
Otley, Anthony R. ; Griffiths, Anne M. ; Hale, Sandra ; Kugathasan, Subra ; Pfefferkorn, Marian ; Mezoff, Adam ; Rosh, Joel ; Tolia, Vasundhara ; Markowitz, James ; Mack, David ; Oliva-Hemker, Maria ; Wyllie, Robert ; Rothbaum, Robert ; Bousvaros, Athos ; Del Rosario, J. Fernando ; Evans, Jonathan ; Blanchard, Wade ; Hyams, Jeffrey. / Health-related quality of life in the first year after a diagnosis of pediatric inflammatory bowel disease. In: Inflammatory bowel diseases. 2006 ; Vol. 12, No. 8. pp. 684-691.
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abstract = "BACKGROUND AND AIMS: Assessment of health-related quality of life (HRQOL) is of increasing importance in the evaluation of new therapies for inflammatory bowel disease (IBD). Available data concerning HRQOL in pediatric patients are sparse and uniformly cross-sectional. The aim of this study was to describe HRQOL and influential factors in newly diagnosed pediatric patients with Crohn's disease and ulcerative colitis during the first 12 months after diagnosis. MATERIALS AND METHODS: Participants were drawn from a large, prospectively derived observational IBD registry of pediatric patients studied through 18 U.S. and Canadian centers. Patients who had completed a baseline IMPACT questionnaire and for whom there were 12 months of follow-up data available were included. In addition to description of cohort, factors that were believed to influence HLQOL were assessed during the course of the year from diagnosis. RESULTS: Two hundred eighteen children met inclusion criteria (77{\%} Crohn's disease, 23 {\%} ulcerative colitis, mean age 12.7 ± 1.9 years). Mean total IMPACT score at baseline was 154, 181 at 6 months, and 191 at 1 year (possible range 0-238, with increasing scores representing better quality of life). Repeated measures analysis showed that age and disease severity significantly negatively affected the IMPACT scores during the course of the year. CONCLUSIONS: In this large prospective pediatric IBD cohort, significant improvement in HRQOL is noted during the year from diagnosis. Mean IMPACT scores varied significantly depending on the disease severity and also decreased with increasing age.",
author = "Otley, {Anthony R.} and Griffiths, {Anne M.} and Sandra Hale and Subra Kugathasan and Marian Pfefferkorn and Adam Mezoff and Joel Rosh and Vasundhara Tolia and James Markowitz and David Mack and Maria Oliva-Hemker and Robert Wyllie and Robert Rothbaum and Athos Bousvaros and {Del Rosario}, {J. Fernando} and Jonathan Evans and Wade Blanchard and Jeffrey Hyams",
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Otley, AR, Griffiths, AM, Hale, S, Kugathasan, S, Pfefferkorn, M, Mezoff, A, Rosh, J, Tolia, V, Markowitz, J, Mack, D, Oliva-Hemker, M, Wyllie, R, Rothbaum, R, Bousvaros, A, Del Rosario, JF, Evans, J, Blanchard, W & Hyams, J 2006, 'Health-related quality of life in the first year after a diagnosis of pediatric inflammatory bowel disease', Inflammatory bowel diseases, vol. 12, no. 8, pp. 684-691. https://doi.org/10.1097/00054725-200608000-00003

Health-related quality of life in the first year after a diagnosis of pediatric inflammatory bowel disease. / Otley, Anthony R.; Griffiths, Anne M.; Hale, Sandra; Kugathasan, Subra; Pfefferkorn, Marian; Mezoff, Adam; Rosh, Joel; Tolia, Vasundhara; Markowitz, James; Mack, David; Oliva-Hemker, Maria; Wyllie, Robert; Rothbaum, Robert; Bousvaros, Athos; Del Rosario, J. Fernando; Evans, Jonathan; Blanchard, Wade; Hyams, Jeffrey.

In: Inflammatory bowel diseases, Vol. 12, No. 8, 01.08.2006, p. 684-691.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Health-related quality of life in the first year after a diagnosis of pediatric inflammatory bowel disease

AU - Otley, Anthony R.

AU - Griffiths, Anne M.

AU - Hale, Sandra

AU - Kugathasan, Subra

AU - Pfefferkorn, Marian

AU - Mezoff, Adam

AU - Rosh, Joel

AU - Tolia, Vasundhara

AU - Markowitz, James

AU - Mack, David

AU - Oliva-Hemker, Maria

AU - Wyllie, Robert

AU - Rothbaum, Robert

AU - Bousvaros, Athos

AU - Del Rosario, J. Fernando

AU - Evans, Jonathan

AU - Blanchard, Wade

AU - Hyams, Jeffrey

PY - 2006/8/1

Y1 - 2006/8/1

N2 - BACKGROUND AND AIMS: Assessment of health-related quality of life (HRQOL) is of increasing importance in the evaluation of new therapies for inflammatory bowel disease (IBD). Available data concerning HRQOL in pediatric patients are sparse and uniformly cross-sectional. The aim of this study was to describe HRQOL and influential factors in newly diagnosed pediatric patients with Crohn's disease and ulcerative colitis during the first 12 months after diagnosis. MATERIALS AND METHODS: Participants were drawn from a large, prospectively derived observational IBD registry of pediatric patients studied through 18 U.S. and Canadian centers. Patients who had completed a baseline IMPACT questionnaire and for whom there were 12 months of follow-up data available were included. In addition to description of cohort, factors that were believed to influence HLQOL were assessed during the course of the year from diagnosis. RESULTS: Two hundred eighteen children met inclusion criteria (77% Crohn's disease, 23 % ulcerative colitis, mean age 12.7 ± 1.9 years). Mean total IMPACT score at baseline was 154, 181 at 6 months, and 191 at 1 year (possible range 0-238, with increasing scores representing better quality of life). Repeated measures analysis showed that age and disease severity significantly negatively affected the IMPACT scores during the course of the year. CONCLUSIONS: In this large prospective pediatric IBD cohort, significant improvement in HRQOL is noted during the year from diagnosis. Mean IMPACT scores varied significantly depending on the disease severity and also decreased with increasing age.

AB - BACKGROUND AND AIMS: Assessment of health-related quality of life (HRQOL) is of increasing importance in the evaluation of new therapies for inflammatory bowel disease (IBD). Available data concerning HRQOL in pediatric patients are sparse and uniformly cross-sectional. The aim of this study was to describe HRQOL and influential factors in newly diagnosed pediatric patients with Crohn's disease and ulcerative colitis during the first 12 months after diagnosis. MATERIALS AND METHODS: Participants were drawn from a large, prospectively derived observational IBD registry of pediatric patients studied through 18 U.S. and Canadian centers. Patients who had completed a baseline IMPACT questionnaire and for whom there were 12 months of follow-up data available were included. In addition to description of cohort, factors that were believed to influence HLQOL were assessed during the course of the year from diagnosis. RESULTS: Two hundred eighteen children met inclusion criteria (77% Crohn's disease, 23 % ulcerative colitis, mean age 12.7 ± 1.9 years). Mean total IMPACT score at baseline was 154, 181 at 6 months, and 191 at 1 year (possible range 0-238, with increasing scores representing better quality of life). Repeated measures analysis showed that age and disease severity significantly negatively affected the IMPACT scores during the course of the year. CONCLUSIONS: In this large prospective pediatric IBD cohort, significant improvement in HRQOL is noted during the year from diagnosis. Mean IMPACT scores varied significantly depending on the disease severity and also decreased with increasing age.

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