Generalized lymphadenopathy with morphologic features of Castleman's disease in an HIV‐positive man

Dennis Lowenthal, Daniel A. Filippa, Mark E. Richardson, Maude Bertoni, David J. Straus

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

In recent years the literature has described a highly lethal “multicentric” variant of classic Castleman's disease (CD) with similar hyperplastic angio‐follicular morphologic features. A 44‐year‐old man who was not known to be part of any established high‐risk group for the acquired immune deficiency syndrome (AIDS) presented with clinical and laboratory features similar to “multicentric” CD. Serologic testing revealed antibody to the human immunodeficiency virus (HIV) by Western blot analysis. It is suggested that “multicentric” CD may be part of the clinicopathologic spectrum of HIV infection, and there should be a high index of suspicion for HIV in patients presenting with generalized lymphadenopathy and histopathologic features of CD.

Original languageEnglish (US)
Pages (from-to)2454-2458
Number of pages5
JournalCancer
Volume60
Issue number10
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

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Giant Lymph Node Hyperplasia
HIV
Virus Diseases
Acquired Immunodeficiency Syndrome
Western Blotting
Antibodies
Lymphadenopathy
Multi-centric Castleman's Disease

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Lowenthal, Dennis ; Filippa, Daniel A. ; Richardson, Mark E. ; Bertoni, Maude ; Straus, David J. / Generalized lymphadenopathy with morphologic features of Castleman's disease in an HIV‐positive man. In: Cancer. 1987 ; Vol. 60, No. 10. pp. 2454-2458.
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Generalized lymphadenopathy with morphologic features of Castleman's disease in an HIV‐positive man. / Lowenthal, Dennis; Filippa, Daniel A.; Richardson, Mark E.; Bertoni, Maude; Straus, David J.

In: Cancer, Vol. 60, No. 10, 01.01.1987, p. 2454-2458.

Research output: Contribution to journalArticle

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