Fuel utilization in neoplastic disease: Implications for the use of nutritional support in cancer patients

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Tumor cell metabolism and the whole-body response to tumor metabolic activity produces a complex derangement, including alterations in carbohydrate oxidation with futile cycling and changes in gluconeogenesis and lipid utilization. An interplay between circulating hormones, lymphocyte-mediated cytokines, and tumor growth factors complicates fuel metabolism in these individuals. Adequate attention to these concepts has not been provided in the studies evaluating the effects of parenteral nutrition in cancer patients that have been performed to date. Therefore, it is impossible to determine the validity of the results. Furthermore, it is possible that some of the detrimental effects of TPN observed in earlier studies were secondary to the inappropriate use of large glucose loads in cancer patients.

Original languageEnglish (US)
JournalNutrition
Volume6
Issue number4 SUPPL.
StatePublished - Sep 14 1990
Externally publishedYes

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Nutritional Support
Neoplasms
Substrate Cycling
Gluconeogenesis
Parenteral Nutrition
Reproducibility of Results
Intercellular Signaling Peptides and Proteins
Carbohydrates
Hormones
Lymphocytes
Cytokines
Lipids
Glucose

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

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Fuel utilization in neoplastic disease : Implications for the use of nutritional support in cancer patients. / Rothkopf, Michael.

In: Nutrition, Vol. 6, No. 4 SUPPL., 14.09.1990.

Research output: Contribution to journalArticle

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