Abstract
Tumor cell metabolism and the whole-body response to tumor metabolic activity produces a complex derangement, including alterations in carbohydrate oxidation with futile cycling and changes in gluconeogenesis and lipid utilization. An interplay between circulating hormones, lymphocyte-mediated cytokines, and tumor growth factors complicates fuel metabolism in these individuals. Adequate attention to these concepts has not been provided in the studies evaluating the effects of parenteral nutrition in cancer patients that have been performed to date. Therefore, it is impossible to determine the validity of the results. Furthermore, it is possible that some of the detrimental effects of TPN observed in earlier studies were secondary to the inappropriate use of large glucose loads in cancer patients.
| Original language | English (US) |
|---|---|
| Journal | Nutrition |
| Volume | 6 |
| Issue number | 4 SUPPL. |
| State | Published - Sep 14 1990 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics
Cite this
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Fuel utilization in neoplastic disease : Implications for the use of nutritional support in cancer patients. / Rothkopf, Michael.
In: Nutrition, Vol. 6, No. 4 SUPPL., 14.09.1990.Research output: Contribution to journal › Article
TY - JOUR
T1 - Fuel utilization in neoplastic disease
T2 - Implications for the use of nutritional support in cancer patients
AU - Rothkopf, Michael
PY - 1990/9/14
Y1 - 1990/9/14
N2 - Tumor cell metabolism and the whole-body response to tumor metabolic activity produces a complex derangement, including alterations in carbohydrate oxidation with futile cycling and changes in gluconeogenesis and lipid utilization. An interplay between circulating hormones, lymphocyte-mediated cytokines, and tumor growth factors complicates fuel metabolism in these individuals. Adequate attention to these concepts has not been provided in the studies evaluating the effects of parenteral nutrition in cancer patients that have been performed to date. Therefore, it is impossible to determine the validity of the results. Furthermore, it is possible that some of the detrimental effects of TPN observed in earlier studies were secondary to the inappropriate use of large glucose loads in cancer patients.
AB - Tumor cell metabolism and the whole-body response to tumor metabolic activity produces a complex derangement, including alterations in carbohydrate oxidation with futile cycling and changes in gluconeogenesis and lipid utilization. An interplay between circulating hormones, lymphocyte-mediated cytokines, and tumor growth factors complicates fuel metabolism in these individuals. Adequate attention to these concepts has not been provided in the studies evaluating the effects of parenteral nutrition in cancer patients that have been performed to date. Therefore, it is impossible to determine the validity of the results. Furthermore, it is possible that some of the detrimental effects of TPN observed in earlier studies were secondary to the inappropriate use of large glucose loads in cancer patients.
UR - http://www.scopus.com/inward/record.url?scp=0025166856&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025166856&partnerID=8YFLogxK
M3 - Article
VL - 6
JO - Nutrition
JF - Nutrition
SN - 0899-9007
IS - 4 SUPPL.
ER -