Failure of tetracycline therapy in early lyme disease

Raymond J. Dattwyler, John J. Halperin

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

We describe the clinical courses of 5 patients with Lyme disease who developed significant late complications, despite receiving tetracycline early in the course of their illness. All 5 patients had been treated for erythema chronicum migrans with a course of tetracycline that met or exceeded current recommendations. The late manifestations of Lyme disease included arthritis, cranial nerve palsy, peripheral neuropathy, chronic fatigue, and changes in mental function. Our findings suggest that the use of tetracycline at a dosage of 250 mg, 4 times a day for 10 days, as a treatment for early Lyme disease should be reconsidered. To determine optimal therapy for early Lyme disease, a study that compares an increased dosage of tetracycline with alternative treatments is indicated.

Original languageEnglish (US)
Pages (from-to)448-450
Number of pages3
JournalArthritis & Rheumatism
Volume30
Issue number4
DOIs
StatePublished - Jan 1 1987
Externally publishedYes

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Lyme Disease
Tetracycline
Erythema Chronicum Migrans
Cranial Nerve Diseases
Peripheral Nervous System Diseases
Therapeutics
Arthritis
Fatigue

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Dattwyler, Raymond J. ; Halperin, John J. / Failure of tetracycline therapy in early lyme disease. In: Arthritis & Rheumatism. 1987 ; Vol. 30, No. 4. pp. 448-450.
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Failure of tetracycline therapy in early lyme disease. / Dattwyler, Raymond J.; Halperin, John J.

In: Arthritis & Rheumatism, Vol. 30, No. 4, 01.01.1987, p. 448-450.

Research output: Contribution to journalArticle

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