Factors predictive of the status of sentinel lymph nodes in melanoma patients from a large multicenter database

Richard L.R. White, Gregory D. Ayers, Virginia H. Stell, Shouluan Ding, Jeffrey E. Gershenwald, Jonathan C. Salo, Barbara A. Pockaj, Richard Essner, Mark Faries, Kim James Charney, Eli Avisar, Axel Hauschild, Friederike Egberts, Bruce J. Averbook, Carlos A. Garberoglio, John T. Vetto, Merrick I. Ross, David Chu, Vijay Trisal, Harald Hoekstra & 11 others Eric Whitman, Harold J. Wanebo, Daniel Debonis, Michael Vezeridis, Aaron Chevinsky, Mohammed Kashani-Sabet, Yu Shyr, Lynne Berry, Zhiguo Zhao, Seng Jaw Soong, Stanley P.L. Leong

Research output: Contribution to journalArticle

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Abstract

Background: Numerous predictive factors for cutaneous melanoma metastases to sentinel lymph nodes have been identified; however, few have been found to be reproducibly significant. This study investigated the significance of factors for predicting regional nodal disease in cutaneous melanoma using a large multicenter database. Methods: Seventeen institutions submitted retrospective and prospective data on 3463 patients undergoing sentinel lymph node (SLN) biopsy for primary melanoma. Multiple demographic and tumor factors were analyzed for correlation with a positive SLN. Univariate and multivariate statistical analyses were performed. Results: Of 3445 analyzable patients, 561 (16.3%) had a positive SLN biopsy. In multivariate analysis of 1526 patients with complete records for 10 variables, increasing Breslow thickness, lymphovascular invasion, ulceration, younger age, the absence of regression, and tumor location on the trunk were statistically significant predictors of a positive SLN. Conclusions: These results confirm the predictive significance of the well-established variables of Breslow thickness, ulceration, age, and location, as well as consistently reported but less well-established variables such as lymphovascular invasion. In addition, the presence of regression was associated with a lower likelihood of a positive SLN. Consideration of multiple tumor parameters should influence the decision for SLN biopsy and the estimation of nodal metastatic disease risk.

Original languageEnglish (US)
Pages (from-to)3593-3600
Number of pages8
JournalAnnals of Surgical Oncology
Volume18
Issue number13
DOIs
StatePublished - Dec 1 2011

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Sentinel Lymph Node Biopsy
Melanoma
Databases
Multivariate Analysis
Neoplasms
Skin
Demography
Neoplasm Metastasis
Sentinel Lymph Node

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

White, R. L. R., Ayers, G. D., Stell, V. H., Ding, S., Gershenwald, J. E., Salo, J. C., ... Leong, S. P. L. (2011). Factors predictive of the status of sentinel lymph nodes in melanoma patients from a large multicenter database. Annals of Surgical Oncology, 18(13), 3593-3600. https://doi.org/10.1245/s10434-011-1826-9
White, Richard L.R. ; Ayers, Gregory D. ; Stell, Virginia H. ; Ding, Shouluan ; Gershenwald, Jeffrey E. ; Salo, Jonathan C. ; Pockaj, Barbara A. ; Essner, Richard ; Faries, Mark ; Charney, Kim James ; Avisar, Eli ; Hauschild, Axel ; Egberts, Friederike ; Averbook, Bruce J. ; Garberoglio, Carlos A. ; Vetto, John T. ; Ross, Merrick I. ; Chu, David ; Trisal, Vijay ; Hoekstra, Harald ; Whitman, Eric ; Wanebo, Harold J. ; Debonis, Daniel ; Vezeridis, Michael ; Chevinsky, Aaron ; Kashani-Sabet, Mohammed ; Shyr, Yu ; Berry, Lynne ; Zhao, Zhiguo ; Soong, Seng Jaw ; Leong, Stanley P.L. / Factors predictive of the status of sentinel lymph nodes in melanoma patients from a large multicenter database. In: Annals of Surgical Oncology. 2011 ; Vol. 18, No. 13. pp. 3593-3600.
@article{248b89cd89c94ab7a2c568be0fad3667,
title = "Factors predictive of the status of sentinel lymph nodes in melanoma patients from a large multicenter database",
abstract = "Background: Numerous predictive factors for cutaneous melanoma metastases to sentinel lymph nodes have been identified; however, few have been found to be reproducibly significant. This study investigated the significance of factors for predicting regional nodal disease in cutaneous melanoma using a large multicenter database. Methods: Seventeen institutions submitted retrospective and prospective data on 3463 patients undergoing sentinel lymph node (SLN) biopsy for primary melanoma. Multiple demographic and tumor factors were analyzed for correlation with a positive SLN. Univariate and multivariate statistical analyses were performed. Results: Of 3445 analyzable patients, 561 (16.3{\%}) had a positive SLN biopsy. In multivariate analysis of 1526 patients with complete records for 10 variables, increasing Breslow thickness, lymphovascular invasion, ulceration, younger age, the absence of regression, and tumor location on the trunk were statistically significant predictors of a positive SLN. Conclusions: These results confirm the predictive significance of the well-established variables of Breslow thickness, ulceration, age, and location, as well as consistently reported but less well-established variables such as lymphovascular invasion. In addition, the presence of regression was associated with a lower likelihood of a positive SLN. Consideration of multiple tumor parameters should influence the decision for SLN biopsy and the estimation of nodal metastatic disease risk.",
author = "White, {Richard L.R.} and Ayers, {Gregory D.} and Stell, {Virginia H.} and Shouluan Ding and Gershenwald, {Jeffrey E.} and Salo, {Jonathan C.} and Pockaj, {Barbara A.} and Richard Essner and Mark Faries and Charney, {Kim James} and Eli Avisar and Axel Hauschild and Friederike Egberts and Averbook, {Bruce J.} and Garberoglio, {Carlos A.} and Vetto, {John T.} and Ross, {Merrick I.} and David Chu and Vijay Trisal and Harald Hoekstra and Eric Whitman and Wanebo, {Harold J.} and Daniel Debonis and Michael Vezeridis and Aaron Chevinsky and Mohammed Kashani-Sabet and Yu Shyr and Lynne Berry and Zhiguo Zhao and Soong, {Seng Jaw} and Leong, {Stanley P.L.}",
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White, RLR, Ayers, GD, Stell, VH, Ding, S, Gershenwald, JE, Salo, JC, Pockaj, BA, Essner, R, Faries, M, Charney, KJ, Avisar, E, Hauschild, A, Egberts, F, Averbook, BJ, Garberoglio, CA, Vetto, JT, Ross, MI, Chu, D, Trisal, V, Hoekstra, H, Whitman, E, Wanebo, HJ, Debonis, D, Vezeridis, M, Chevinsky, A, Kashani-Sabet, M, Shyr, Y, Berry, L, Zhao, Z, Soong, SJ & Leong, SPL 2011, 'Factors predictive of the status of sentinel lymph nodes in melanoma patients from a large multicenter database', Annals of Surgical Oncology, vol. 18, no. 13, pp. 3593-3600. https://doi.org/10.1245/s10434-011-1826-9

Factors predictive of the status of sentinel lymph nodes in melanoma patients from a large multicenter database. / White, Richard L.R.; Ayers, Gregory D.; Stell, Virginia H.; Ding, Shouluan; Gershenwald, Jeffrey E.; Salo, Jonathan C.; Pockaj, Barbara A.; Essner, Richard; Faries, Mark; Charney, Kim James; Avisar, Eli; Hauschild, Axel; Egberts, Friederike; Averbook, Bruce J.; Garberoglio, Carlos A.; Vetto, John T.; Ross, Merrick I.; Chu, David; Trisal, Vijay; Hoekstra, Harald; Whitman, Eric; Wanebo, Harold J.; Debonis, Daniel; Vezeridis, Michael; Chevinsky, Aaron; Kashani-Sabet, Mohammed; Shyr, Yu; Berry, Lynne; Zhao, Zhiguo; Soong, Seng Jaw; Leong, Stanley P.L.

In: Annals of Surgical Oncology, Vol. 18, No. 13, 01.12.2011, p. 3593-3600.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Factors predictive of the status of sentinel lymph nodes in melanoma patients from a large multicenter database

AU - White, Richard L.R.

AU - Ayers, Gregory D.

AU - Stell, Virginia H.

AU - Ding, Shouluan

AU - Gershenwald, Jeffrey E.

AU - Salo, Jonathan C.

AU - Pockaj, Barbara A.

AU - Essner, Richard

AU - Faries, Mark

AU - Charney, Kim James

AU - Avisar, Eli

AU - Hauschild, Axel

AU - Egberts, Friederike

AU - Averbook, Bruce J.

AU - Garberoglio, Carlos A.

AU - Vetto, John T.

AU - Ross, Merrick I.

AU - Chu, David

AU - Trisal, Vijay

AU - Hoekstra, Harald

AU - Whitman, Eric

AU - Wanebo, Harold J.

AU - Debonis, Daniel

AU - Vezeridis, Michael

AU - Chevinsky, Aaron

AU - Kashani-Sabet, Mohammed

AU - Shyr, Yu

AU - Berry, Lynne

AU - Zhao, Zhiguo

AU - Soong, Seng Jaw

AU - Leong, Stanley P.L.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Background: Numerous predictive factors for cutaneous melanoma metastases to sentinel lymph nodes have been identified; however, few have been found to be reproducibly significant. This study investigated the significance of factors for predicting regional nodal disease in cutaneous melanoma using a large multicenter database. Methods: Seventeen institutions submitted retrospective and prospective data on 3463 patients undergoing sentinel lymph node (SLN) biopsy for primary melanoma. Multiple demographic and tumor factors were analyzed for correlation with a positive SLN. Univariate and multivariate statistical analyses were performed. Results: Of 3445 analyzable patients, 561 (16.3%) had a positive SLN biopsy. In multivariate analysis of 1526 patients with complete records for 10 variables, increasing Breslow thickness, lymphovascular invasion, ulceration, younger age, the absence of regression, and tumor location on the trunk were statistically significant predictors of a positive SLN. Conclusions: These results confirm the predictive significance of the well-established variables of Breslow thickness, ulceration, age, and location, as well as consistently reported but less well-established variables such as lymphovascular invasion. In addition, the presence of regression was associated with a lower likelihood of a positive SLN. Consideration of multiple tumor parameters should influence the decision for SLN biopsy and the estimation of nodal metastatic disease risk.

AB - Background: Numerous predictive factors for cutaneous melanoma metastases to sentinel lymph nodes have been identified; however, few have been found to be reproducibly significant. This study investigated the significance of factors for predicting regional nodal disease in cutaneous melanoma using a large multicenter database. Methods: Seventeen institutions submitted retrospective and prospective data on 3463 patients undergoing sentinel lymph node (SLN) biopsy for primary melanoma. Multiple demographic and tumor factors were analyzed for correlation with a positive SLN. Univariate and multivariate statistical analyses were performed. Results: Of 3445 analyzable patients, 561 (16.3%) had a positive SLN biopsy. In multivariate analysis of 1526 patients with complete records for 10 variables, increasing Breslow thickness, lymphovascular invasion, ulceration, younger age, the absence of regression, and tumor location on the trunk were statistically significant predictors of a positive SLN. Conclusions: These results confirm the predictive significance of the well-established variables of Breslow thickness, ulceration, age, and location, as well as consistently reported but less well-established variables such as lymphovascular invasion. In addition, the presence of regression was associated with a lower likelihood of a positive SLN. Consideration of multiple tumor parameters should influence the decision for SLN biopsy and the estimation of nodal metastatic disease risk.

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U2 - 10.1245/s10434-011-1826-9

DO - 10.1245/s10434-011-1826-9

M3 - Article

VL - 18

SP - 3593

EP - 3600

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

IS - 13

ER -