Experimental studies on the healing of colonic anastomoses

Mark J. Koruda, Rolando Rolandelli

Research output: Contribution to journalArticle

149 Citations (Scopus)

Abstract

The leakage of colonic anastomoses is a potentially devastating surgical complication. Several factors, such as bowel preparation prior to surgery, surgical technique, nutritional status, and intervening pathological conditions, have been identified as significantly influencing the healing of colonic anastomoses. Due to the multifactorial nature, it is difficult to investigate the mechanisms of occurrence and prevention of colonic dehiscence in the clinical setting. For this reason, many experimental models have been used to study colonic healing and the pathogenesis of anastomotic failure. This report reviews the use of animal models for the study of colonic anastomotic healing. Special emphasis is devoted to the rationale for selecting animal models, parameters of healing, factors influencing anastomotic healing as well as the clinical potential of dietary and pharmacologic manipulations proposed to improve colonic healing.

Original languageEnglish (US)
Pages (from-to)504-515
Number of pages12
JournalJournal of Surgical Research
Volume48
Issue number5
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

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Animal Models
Nutritional Status
Theoretical Models

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

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Experimental studies on the healing of colonic anastomoses. / Koruda, Mark J.; Rolandelli, Rolando.

In: Journal of Surgical Research, Vol. 48, No. 5, 01.01.1990, p. 504-515.

Research output: Contribution to journalArticle

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