Exercise left ventriculography utilizing intravenous digital angiography

Harvey L. Goldberg, Jeffrey W. Moses, Jeffrey S. Borer, Jeffrey Fisher, Israel Tamari, Nancy T. Skelly, Barry Cohen

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Exercise left ventriculography has been shown to be a sensitive and specific tool for the detection of coronary artery disease. At the present time, such studies require radionuclide-based methods. Computer-based techniques recently have been shown to provide high resolution images of the left ventricle when the levophase of an intravenous injection of radiopaque contrast medium is imaged with fluoroscopy. To evaluate the possible efficacy of using “intravenous digital subtraction left ventriculograms” in exercise ventriculography, such ventriculograms were performed at rest and during maximal supine bicycle exercise in 31 patients. Studies that could be analyzed were obtained in 29 patients. In 21 patients with coronary artery disease, ejection fraction was 58% at rest and 45% with exercise (p < 0.001 vs. rest). In contrast, in seven patients with no coronary artery disease, ejection fraction was 65% at rest and 69% with exercise (difference not significant). In a subgroup of 8 patients with “severe” coronary obstruction, the change in ejection fraction from rest to exercise was -18%, while in the remaining 13 patients with less severe disease, it was -9% (p < 0.001). All patients with coronary artery disease manifested new or worsening segmental wall abnormality with exercise, compared with two of seven patients without coronary disease (p < 0.01). Sixteen patients underwent rest and exercise radionuclide cineangiography in addition to digital subtraction angiography. There was a strong correlation between the two techniques for ejection fraction at rest (r = 0.78, p < 0.001), ejection fraction with exercise (r = 0.83, p < 0.001) and change in ejection fraction from rest to exercise (r = 0.88, p < 0.001). It is concluded that exercise ventriculography utilizing intravenous digital subtraction angiography is feasible and provides information comparable with that available from radionuclide cineangiography.

Original languageEnglish (US)
Pages (from-to)1092-1098
Number of pages7
JournalJournal of the American College of Cardiology
Volume2
Issue number6
DOIs
StatePublished - Jan 1 1983

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Angiography
Exercise
Coronary Artery Disease
Radioisotopes
Cineangiography
Digital Subtraction Angiography
Contrast Media
Fluoroscopy
Intravenous Injections
Heart Ventricles
Coronary Disease

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Goldberg, Harvey L. ; Moses, Jeffrey W. ; Borer, Jeffrey S. ; Fisher, Jeffrey ; Tamari, Israel ; Skelly, Nancy T. ; Cohen, Barry. / Exercise left ventriculography utilizing intravenous digital angiography. In: Journal of the American College of Cardiology. 1983 ; Vol. 2, No. 6. pp. 1092-1098.
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Exercise left ventriculography utilizing intravenous digital angiography. / Goldberg, Harvey L.; Moses, Jeffrey W.; Borer, Jeffrey S.; Fisher, Jeffrey; Tamari, Israel; Skelly, Nancy T.; Cohen, Barry.

In: Journal of the American College of Cardiology, Vol. 2, No. 6, 01.01.1983, p. 1092-1098.

Research output: Contribution to journalArticle

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