Exacerbation of rheumatoid arthritis after termination of chemotherapy for breast carcinoma

Elliot D. Rosenstein, Neil Kramer, Stuart P. Leitner, Richard A. Michaelson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Three women with breast carcinoma were treated with combination chemotherapy, including cyclophosphamide, 5-fluorouracil, and methotrexate, after mastectomy. Within two months of termination of chemotherapy, all 3 patients developed florid synovitis. Two patients had prior clinical manifestations consistent with rheumatoid arthritis; one patient had no antecedent history of arthritis. We suggest that this presentation may represent exacerbation of mild or subclinical rheumatoid arthritis as a consequence of withdrawal of methotrexate therapy.

Original languageEnglish (US)
Pages (from-to)1988-1990
Number of pages3
JournalJournal of Rheumatology
Volume23
Issue number11
StatePublished - Nov 19 1996
Externally publishedYes

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Rheumatoid Arthritis
Breast Neoplasms
Methotrexate
Drug Therapy
Synovitis
Mastectomy
Combination Drug Therapy
Fluorouracil
Cyclophosphamide
Arthritis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

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Exacerbation of rheumatoid arthritis after termination of chemotherapy for breast carcinoma. / Rosenstein, Elliot D.; Kramer, Neil; Leitner, Stuart P.; Michaelson, Richard A.

In: Journal of Rheumatology, Vol. 23, No. 11, 19.11.1996, p. 1988-1990.

Research output: Contribution to journalArticle

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