Abstract
Three women with breast carcinoma were treated with combination chemotherapy, including cyclophosphamide, 5-fluorouracil, and methotrexate, after mastectomy. Within two months of termination of chemotherapy, all 3 patients developed florid synovitis. Two patients had prior clinical manifestations consistent with rheumatoid arthritis; one patient had no antecedent history of arthritis. We suggest that this presentation may represent exacerbation of mild or subclinical rheumatoid arthritis as a consequence of withdrawal of methotrexate therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1988-1990 |
| Number of pages | 3 |
| Journal | Journal of Rheumatology |
| Volume | 23 |
| Issue number | 11 |
| State | Published - Nov 19 1996 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Rheumatology
- Immunology and Allergy
- Immunology
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Exacerbation of rheumatoid arthritis after termination of chemotherapy for breast carcinoma. / Rosenstein, Elliot D.; Kramer, Neil; Leitner, Stuart P.; Michaelson, Richard A.
In: Journal of Rheumatology, Vol. 23, No. 11, 19.11.1996, p. 1988-1990.Research output: Contribution to journal › Article
TY - JOUR
T1 - Exacerbation of rheumatoid arthritis after termination of chemotherapy for breast carcinoma
AU - Rosenstein, Elliot D.
AU - Kramer, Neil
AU - Leitner, Stuart P.
AU - Michaelson, Richard A.
PY - 1996/11/19
Y1 - 1996/11/19
N2 - Three women with breast carcinoma were treated with combination chemotherapy, including cyclophosphamide, 5-fluorouracil, and methotrexate, after mastectomy. Within two months of termination of chemotherapy, all 3 patients developed florid synovitis. Two patients had prior clinical manifestations consistent with rheumatoid arthritis; one patient had no antecedent history of arthritis. We suggest that this presentation may represent exacerbation of mild or subclinical rheumatoid arthritis as a consequence of withdrawal of methotrexate therapy.
AB - Three women with breast carcinoma were treated with combination chemotherapy, including cyclophosphamide, 5-fluorouracil, and methotrexate, after mastectomy. Within two months of termination of chemotherapy, all 3 patients developed florid synovitis. Two patients had prior clinical manifestations consistent with rheumatoid arthritis; one patient had no antecedent history of arthritis. We suggest that this presentation may represent exacerbation of mild or subclinical rheumatoid arthritis as a consequence of withdrawal of methotrexate therapy.
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UR - http://www.scopus.com/inward/citedby.url?scp=0029952940&partnerID=8YFLogxK
M3 - Article
C2 - 8923380
AN - SCOPUS:0029952940
VL - 23
SP - 1988
EP - 1990
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 11
ER -