Evolution of the temporal contraction sequence after acute experimental myocardial infarction

Kathryn J. Ascah, Linda Gillam, Ravin Davidoff, Thomas D. Franklin, John B. Newell, Robert D. Hogan, Arthur E. Weyman

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The effect of infarct maturation on the temporal sequence of contraction within infarct zones has not previously been described. Accordingly, the time-varying pattern of contraction within ischemic/infarct zones was studied with use of cross-sectional echocardiography in 17 dogs at 10 min to 6 weeks after acute experimental myocardial infarction. Left ventricular short-axis images were digitized from end-diastole to end-systole and endocardial fractional radial change along 36 evenly spaced rays was calculated. The circumferential extent of dyskinesia and the number of rays that exhibited maximal dyskinesia were determined for each decile of the normalized contraction sequence. Between 10 min and 1 week after infarction, the greatest circumferential extent of dyskinesia occurred between the 3rd and 4th deciles of the normalized contraction sequence. However, as the infarct matured, the greatest spatial expanse of dyskinesia was noted to occur progressively earlier in the contraction sequence (second decile at 6 weeks), and the extent of mid- to late-systolic dyskinesia decreased markedly. Whereas end-systolic dyskinesia was present in 30% to 50% of ischemic/infarct zone rays from 10 min to 48 h, end-systolic dyskinesia was no longer observed at 6 weeks. Similarly, the maximal amplitude of dyskinesia was most commonly observed during midsystole from 10 min to 48 h, but occurred progressively earlier as the infarct matured, falling during the first decile at 6 weeks after infarction. These data suggest that maximal circumferential extent and amplitude of dyskinesia occur progressively earlier in the systolic contraction sequence as the infarct matures. An awareness of these temporal variations in the contraction pattern is important in the use of wall motion as a marker of left ventricular dysfunction after myocardial infarction.

Original languageEnglish (US)
Pages (from-to)730-736
Number of pages7
JournalJournal of the American College of Cardiology
Volume13
Issue number3
DOIs
StatePublished - Mar 1 1989
Externally publishedYes

Fingerprint

Dyskinesias
Myocardial Infarction
Infarction
Diastole
Systole
Left Ventricular Dysfunction
Echocardiography
Dogs

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Ascah, Kathryn J. ; Gillam, Linda ; Davidoff, Ravin ; Franklin, Thomas D. ; Newell, John B. ; Hogan, Robert D. ; Weyman, Arthur E. / Evolution of the temporal contraction sequence after acute experimental myocardial infarction. In: Journal of the American College of Cardiology. 1989 ; Vol. 13, No. 3. pp. 730-736.
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Evolution of the temporal contraction sequence after acute experimental myocardial infarction. / Ascah, Kathryn J.; Gillam, Linda; Davidoff, Ravin; Franklin, Thomas D.; Newell, John B.; Hogan, Robert D.; Weyman, Arthur E.

In: Journal of the American College of Cardiology, Vol. 13, No. 3, 01.03.1989, p. 730-736.

Research output: Contribution to journalArticle

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