Erythrocytic glutathione in cystic fibrosis

A possible marker of pulmonary dysfunction

S. Mangione, D. D. Patel, B. R. Levin, Stanley Fiel

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

To evaluate the role of red blood cell (RBC) antioxidants as clinical markers of oxidative exposure, we measured RBC glutathione (GSH) concentrations in 32 adult patients with cystic fibrosis (CF), and 8 healthy age-matched control subjects. We chose patients with CF because this disease is characterized by severe bronchial inflammation and marked oxidant- antioxidant imbalance. Although the GSH concentration of the two study groups was not significantly different, the RBC GSH concentration of patients with CF had a greater variability (p=0.01) and was also inversely and significantly correlated to tests of pulmonary function (p<0.05). These data indicate a large and significant interindividual variability of erythrocytic antioxidants in patients with CF, with a compensatory, but probably inadequate, increase in patients with more severe respiratory deterioration. Red blood cell GSH concentration may thus provide a biologic marker for disease severity and a rationale for antioxidant manipulation in these patients.

Original languageEnglish (US)
Pages (from-to)1470-1473
Number of pages4
JournalChest
Volume105
Issue number5
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Cystic Fibrosis
Glutathione
Lung
Antioxidants
Erythrocytes
Biomarkers
Respiratory Function Tests
Oxidants
Inflammation

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Mangione, S. ; Patel, D. D. ; Levin, B. R. ; Fiel, Stanley. / Erythrocytic glutathione in cystic fibrosis : A possible marker of pulmonary dysfunction. In: Chest. 1994 ; Vol. 105, No. 5. pp. 1470-1473.
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Erythrocytic glutathione in cystic fibrosis : A possible marker of pulmonary dysfunction. / Mangione, S.; Patel, D. D.; Levin, B. R.; Fiel, Stanley.

In: Chest, Vol. 105, No. 5, 01.01.1994, p. 1470-1473.

Research output: Contribution to journalArticle

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