Efficacy of short-term corticosteroid therapy in outpatient treatment of acute bronchial asthma

Stanley B. Fiel, Morris A. Swartz, Karen Glanz, Mildred E. Francis

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

A group of adults with 76 episodes of acute asthma needing emergency therapy, but not requiring hospitalization, were discharged from an emergency department following standardized therapy with bronchodilators. Upon discharge, the patients were treated with a controlled regimen of oral theophylline, and were randomly assigned in double-blind manner to either a placebo treatment (42 patient episodes) or a corticosteroid treatment group (34 patient episodes). The latter were given an intravenous bolus of methylprednisolone followed by an eight-day tapering course of oral methylprednisolone, starting at 32 mg twice a day. Follow-up was carried out seven or 10 days after treatment in the emergency department. Relapse could not be predicted on the basis of peak expiratory flow rates measured during care in the emergency department. Those patients who received corticosteroids had a decrease in the need for repeated emergency care (5.9 percent versus 21 percent for placebo) and fewer respiratory symptoms (15.6 percent versus 36.4 percent for placebo). It is concluded that a short course of high-dose corticosteroids in outpatients reduces the relapse rate and symptoms following an acute asthmatic attack.

Original languageEnglish (US)
Pages (from-to)259-262
Number of pages4
JournalThe American Journal of Medicine
Volume75
Issue number2
DOIs
StatePublished - Jan 1 1983

Fingerprint

Adrenal Cortex Hormones
Outpatients
Asthma
Hospital Emergency Service
Placebos
Methylprednisolone
Peak Expiratory Flow Rate
Recurrence
Emergency Treatment
Bronchodilator Agents
Emergency Medical Services
Therapeutics
Theophylline
Hospitalization

All Science Journal Classification (ASJC) codes

  • Nursing(all)

Cite this

Fiel, Stanley B. ; Swartz, Morris A. ; Glanz, Karen ; Francis, Mildred E. / Efficacy of short-term corticosteroid therapy in outpatient treatment of acute bronchial asthma. In: The American Journal of Medicine. 1983 ; Vol. 75, No. 2. pp. 259-262.
@article{95298e0b0eac4d3da12ff91cb4e67e94,
title = "Efficacy of short-term corticosteroid therapy in outpatient treatment of acute bronchial asthma",
abstract = "A group of adults with 76 episodes of acute asthma needing emergency therapy, but not requiring hospitalization, were discharged from an emergency department following standardized therapy with bronchodilators. Upon discharge, the patients were treated with a controlled regimen of oral theophylline, and were randomly assigned in double-blind manner to either a placebo treatment (42 patient episodes) or a corticosteroid treatment group (34 patient episodes). The latter were given an intravenous bolus of methylprednisolone followed by an eight-day tapering course of oral methylprednisolone, starting at 32 mg twice a day. Follow-up was carried out seven or 10 days after treatment in the emergency department. Relapse could not be predicted on the basis of peak expiratory flow rates measured during care in the emergency department. Those patients who received corticosteroids had a decrease in the need for repeated emergency care (5.9 percent versus 21 percent for placebo) and fewer respiratory symptoms (15.6 percent versus 36.4 percent for placebo). It is concluded that a short course of high-dose corticosteroids in outpatients reduces the relapse rate and symptoms following an acute asthmatic attack.",
author = "Fiel, {Stanley B.} and Swartz, {Morris A.} and Karen Glanz and Francis, {Mildred E.}",
year = "1983",
month = "1",
day = "1",
doi = "10.1016/0002-9343(83)91202-0",
language = "English (US)",
volume = "75",
pages = "259--262",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "2",

}

Efficacy of short-term corticosteroid therapy in outpatient treatment of acute bronchial asthma. / Fiel, Stanley B.; Swartz, Morris A.; Glanz, Karen; Francis, Mildred E.

In: The American Journal of Medicine, Vol. 75, No. 2, 01.01.1983, p. 259-262.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Efficacy of short-term corticosteroid therapy in outpatient treatment of acute bronchial asthma

AU - Fiel, Stanley B.

AU - Swartz, Morris A.

AU - Glanz, Karen

AU - Francis, Mildred E.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - A group of adults with 76 episodes of acute asthma needing emergency therapy, but not requiring hospitalization, were discharged from an emergency department following standardized therapy with bronchodilators. Upon discharge, the patients were treated with a controlled regimen of oral theophylline, and were randomly assigned in double-blind manner to either a placebo treatment (42 patient episodes) or a corticosteroid treatment group (34 patient episodes). The latter were given an intravenous bolus of methylprednisolone followed by an eight-day tapering course of oral methylprednisolone, starting at 32 mg twice a day. Follow-up was carried out seven or 10 days after treatment in the emergency department. Relapse could not be predicted on the basis of peak expiratory flow rates measured during care in the emergency department. Those patients who received corticosteroids had a decrease in the need for repeated emergency care (5.9 percent versus 21 percent for placebo) and fewer respiratory symptoms (15.6 percent versus 36.4 percent for placebo). It is concluded that a short course of high-dose corticosteroids in outpatients reduces the relapse rate and symptoms following an acute asthmatic attack.

AB - A group of adults with 76 episodes of acute asthma needing emergency therapy, but not requiring hospitalization, were discharged from an emergency department following standardized therapy with bronchodilators. Upon discharge, the patients were treated with a controlled regimen of oral theophylline, and were randomly assigned in double-blind manner to either a placebo treatment (42 patient episodes) or a corticosteroid treatment group (34 patient episodes). The latter were given an intravenous bolus of methylprednisolone followed by an eight-day tapering course of oral methylprednisolone, starting at 32 mg twice a day. Follow-up was carried out seven or 10 days after treatment in the emergency department. Relapse could not be predicted on the basis of peak expiratory flow rates measured during care in the emergency department. Those patients who received corticosteroids had a decrease in the need for repeated emergency care (5.9 percent versus 21 percent for placebo) and fewer respiratory symptoms (15.6 percent versus 36.4 percent for placebo). It is concluded that a short course of high-dose corticosteroids in outpatients reduces the relapse rate and symptoms following an acute asthmatic attack.

UR - http://www.scopus.com/inward/record.url?scp=0020610201&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020610201&partnerID=8YFLogxK

U2 - 10.1016/0002-9343(83)91202-0

DO - 10.1016/0002-9343(83)91202-0

M3 - Article

C2 - 6881177

AN - SCOPUS:0020610201

VL - 75

SP - 259

EP - 262

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

IS - 2

ER -