Effects of selectively altering collateral driving pressure on regional perfusion and function in occluded coronary bed in the dog

S. Kaul, N. G. Pandian, J. L. Guerrero, Linda Gillam, R. D. Okada, A. E. Weyman

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Abstract

To determine whether selectively altering the coronary perfusion pressure in the adjacent nonoccluded vessel has any influence on the occluded bed, the effects of alterations in the perfusion pressure of the left anterior descending coronary artery on the perfusion and function of the acutely occluded left circumflex coronary (LC) arterial bed were studied in 10 anesthetized open-chest dogs. Radiolabelled microsphere-assessed regional myocardial perfusion and endocardial excursion determined by two-dimensional echocardiography were measured during control conditions prior to mid-LC occlusion with left anterior descending coronary arterial pressure (LADP) equal to aortic pressure (AoP) (Stage 0) and to 3 randomly performed postocclusion stages. At each postocclusion stage, the perfusion territory of the occluded LC bed (area at risk) was measured in vivo using myocardial contrast two-dimensional echocardiography. During Stage 1 (LADP = AoP), area at risk was 5.1 ± 0.9 cm2 (x ± 1 SD) and transmural blood flow to the LC arterial bed decreased from 0.96 ± 0.50 ml/min/g (Stage 0) to 0.16 ± 0.12 ml/min/g (p < 0.01), while endocardial excursion decreased from 28.0 ± 9.0% to 2.0 ± 10.0% (p < 0.01). During Stage 2 (LADP > AoP), area at risk decreased to 4.4 ± 1.0 cm2 compared with Stage 1 (p < 0.01), and transmural blood flow, endocardial: epicardial blood flow ratio, and endocardial excursion increased to 0.51 ± 0.39 ml/min/g, 0.64 ± 0.20, and 14 ± 6%, respectively (p < 0.01). In contrast, during Stage 3 (LADP < AoP), although the area at risk increased (5.6 ± 0.7 cm2, p < 0.01) and transmural blood decreased (0.10 ± 0.10 ml/min/g, p < 0.01) compared with Stage 1, endocardial blood flow, endocardial:epicardial blood flow ratio, and endocardial excursion were unchanged (0.11 ± 0.16 ml/min/g, 0.52 ± 0.30, and 1.0 ± 4.0%, respectively). We conclude that significant lateral border zones exit during acute coronary ischemia, which can be influenced positively by selectively increasing the collateral driving pressure. In contrast, although the area at risk increases, when the collateral driving pressure is decreased, the endocardial blood flow and excursion in the area at risk do not further decrease.

Original languageEnglish (US)
Pages (from-to)77-85
Number of pages9
JournalCirculation Research
Volume61
Issue number1
DOIs
StatePublished - Jan 1 1987

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Arterial Pressure
Perfusion
Dogs
Pressure
Echocardiography
Coronary Occlusion
Microspheres
Coronary Vessels
Thorax
Ischemia

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Kaul, S. ; Pandian, N. G. ; Guerrero, J. L. ; Gillam, Linda ; Okada, R. D. ; Weyman, A. E. / Effects of selectively altering collateral driving pressure on regional perfusion and function in occluded coronary bed in the dog. In: Circulation Research. 1987 ; Vol. 61, No. 1. pp. 77-85.
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title = "Effects of selectively altering collateral driving pressure on regional perfusion and function in occluded coronary bed in the dog",
abstract = "To determine whether selectively altering the coronary perfusion pressure in the adjacent nonoccluded vessel has any influence on the occluded bed, the effects of alterations in the perfusion pressure of the left anterior descending coronary artery on the perfusion and function of the acutely occluded left circumflex coronary (LC) arterial bed were studied in 10 anesthetized open-chest dogs. Radiolabelled microsphere-assessed regional myocardial perfusion and endocardial excursion determined by two-dimensional echocardiography were measured during control conditions prior to mid-LC occlusion with left anterior descending coronary arterial pressure (LADP) equal to aortic pressure (AoP) (Stage 0) and to 3 randomly performed postocclusion stages. At each postocclusion stage, the perfusion territory of the occluded LC bed (area at risk) was measured in vivo using myocardial contrast two-dimensional echocardiography. During Stage 1 (LADP = AoP), area at risk was 5.1 ± 0.9 cm2 (x ± 1 SD) and transmural blood flow to the LC arterial bed decreased from 0.96 ± 0.50 ml/min/g (Stage 0) to 0.16 ± 0.12 ml/min/g (p < 0.01), while endocardial excursion decreased from 28.0 ± 9.0{\%} to 2.0 ± 10.0{\%} (p < 0.01). During Stage 2 (LADP > AoP), area at risk decreased to 4.4 ± 1.0 cm2 compared with Stage 1 (p < 0.01), and transmural blood flow, endocardial: epicardial blood flow ratio, and endocardial excursion increased to 0.51 ± 0.39 ml/min/g, 0.64 ± 0.20, and 14 ± 6{\%}, respectively (p < 0.01). In contrast, during Stage 3 (LADP < AoP), although the area at risk increased (5.6 ± 0.7 cm2, p < 0.01) and transmural blood decreased (0.10 ± 0.10 ml/min/g, p < 0.01) compared with Stage 1, endocardial blood flow, endocardial:epicardial blood flow ratio, and endocardial excursion were unchanged (0.11 ± 0.16 ml/min/g, 0.52 ± 0.30, and 1.0 ± 4.0{\%}, respectively). We conclude that significant lateral border zones exit during acute coronary ischemia, which can be influenced positively by selectively increasing the collateral driving pressure. In contrast, although the area at risk increases, when the collateral driving pressure is decreased, the endocardial blood flow and excursion in the area at risk do not further decrease.",
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Effects of selectively altering collateral driving pressure on regional perfusion and function in occluded coronary bed in the dog. / Kaul, S.; Pandian, N. G.; Guerrero, J. L.; Gillam, Linda; Okada, R. D.; Weyman, A. E.

In: Circulation Research, Vol. 61, No. 1, 01.01.1987, p. 77-85.

Research output: Contribution to journalArticle

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T1 - Effects of selectively altering collateral driving pressure on regional perfusion and function in occluded coronary bed in the dog

AU - Kaul, S.

AU - Pandian, N. G.

AU - Guerrero, J. L.

AU - Gillam, Linda

AU - Okada, R. D.

AU - Weyman, A. E.

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N2 - To determine whether selectively altering the coronary perfusion pressure in the adjacent nonoccluded vessel has any influence on the occluded bed, the effects of alterations in the perfusion pressure of the left anterior descending coronary artery on the perfusion and function of the acutely occluded left circumflex coronary (LC) arterial bed were studied in 10 anesthetized open-chest dogs. Radiolabelled microsphere-assessed regional myocardial perfusion and endocardial excursion determined by two-dimensional echocardiography were measured during control conditions prior to mid-LC occlusion with left anterior descending coronary arterial pressure (LADP) equal to aortic pressure (AoP) (Stage 0) and to 3 randomly performed postocclusion stages. At each postocclusion stage, the perfusion territory of the occluded LC bed (area at risk) was measured in vivo using myocardial contrast two-dimensional echocardiography. During Stage 1 (LADP = AoP), area at risk was 5.1 ± 0.9 cm2 (x ± 1 SD) and transmural blood flow to the LC arterial bed decreased from 0.96 ± 0.50 ml/min/g (Stage 0) to 0.16 ± 0.12 ml/min/g (p < 0.01), while endocardial excursion decreased from 28.0 ± 9.0% to 2.0 ± 10.0% (p < 0.01). During Stage 2 (LADP > AoP), area at risk decreased to 4.4 ± 1.0 cm2 compared with Stage 1 (p < 0.01), and transmural blood flow, endocardial: epicardial blood flow ratio, and endocardial excursion increased to 0.51 ± 0.39 ml/min/g, 0.64 ± 0.20, and 14 ± 6%, respectively (p < 0.01). In contrast, during Stage 3 (LADP < AoP), although the area at risk increased (5.6 ± 0.7 cm2, p < 0.01) and transmural blood decreased (0.10 ± 0.10 ml/min/g, p < 0.01) compared with Stage 1, endocardial blood flow, endocardial:epicardial blood flow ratio, and endocardial excursion were unchanged (0.11 ± 0.16 ml/min/g, 0.52 ± 0.30, and 1.0 ± 4.0%, respectively). We conclude that significant lateral border zones exit during acute coronary ischemia, which can be influenced positively by selectively increasing the collateral driving pressure. In contrast, although the area at risk increases, when the collateral driving pressure is decreased, the endocardial blood flow and excursion in the area at risk do not further decrease.

AB - To determine whether selectively altering the coronary perfusion pressure in the adjacent nonoccluded vessel has any influence on the occluded bed, the effects of alterations in the perfusion pressure of the left anterior descending coronary artery on the perfusion and function of the acutely occluded left circumflex coronary (LC) arterial bed were studied in 10 anesthetized open-chest dogs. Radiolabelled microsphere-assessed regional myocardial perfusion and endocardial excursion determined by two-dimensional echocardiography were measured during control conditions prior to mid-LC occlusion with left anterior descending coronary arterial pressure (LADP) equal to aortic pressure (AoP) (Stage 0) and to 3 randomly performed postocclusion stages. At each postocclusion stage, the perfusion territory of the occluded LC bed (area at risk) was measured in vivo using myocardial contrast two-dimensional echocardiography. During Stage 1 (LADP = AoP), area at risk was 5.1 ± 0.9 cm2 (x ± 1 SD) and transmural blood flow to the LC arterial bed decreased from 0.96 ± 0.50 ml/min/g (Stage 0) to 0.16 ± 0.12 ml/min/g (p < 0.01), while endocardial excursion decreased from 28.0 ± 9.0% to 2.0 ± 10.0% (p < 0.01). During Stage 2 (LADP > AoP), area at risk decreased to 4.4 ± 1.0 cm2 compared with Stage 1 (p < 0.01), and transmural blood flow, endocardial: epicardial blood flow ratio, and endocardial excursion increased to 0.51 ± 0.39 ml/min/g, 0.64 ± 0.20, and 14 ± 6%, respectively (p < 0.01). In contrast, during Stage 3 (LADP < AoP), although the area at risk increased (5.6 ± 0.7 cm2, p < 0.01) and transmural blood decreased (0.10 ± 0.10 ml/min/g, p < 0.01) compared with Stage 1, endocardial blood flow, endocardial:epicardial blood flow ratio, and endocardial excursion were unchanged (0.11 ± 0.16 ml/min/g, 0.52 ± 0.30, and 1.0 ± 4.0%, respectively). We conclude that significant lateral border zones exit during acute coronary ischemia, which can be influenced positively by selectively increasing the collateral driving pressure. In contrast, although the area at risk increases, when the collateral driving pressure is decreased, the endocardial blood flow and excursion in the area at risk do not further decrease.

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