Effects of propranolol on bone metabolism in the rat

Barbara Minkowitz, Adele L. Boskey, Joseph M. Lane, Hubert S. Pearlman, Vincent J. Vigorita

Research output: Contribution to journalArticle

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Abstract

Propranolol, a nonspecific β‐blocker, has many physiologic effects. Its effects on bone in vivo are unknown, although β receptor sites have been found on osteoblasts. In this study, the hypothesis tested was that low doses of propranolol could alter bone properties and enhance orthotopic endochondral bone formation. In a group of nonsurgical rats, propranolol treatment increased formation. In a group of nonsurgical rats, propranolol treatment increased femoral torsional strength on biomechanical testing. In the rat surgical model used, right femora were fixed to a polyethylene plate and then defects were created mid‐diaphysis and subsequently filled with demineralized bone matrix. These rats (defect rats) were randomly divided into groups that were given propranolol or a saline carrier for 19 consecutive days. In the defect rats, increased trabecular femoral metaphyseal mineral apposition rates were observed in propranolol‐treated groups. Densitometry and roentgenographic scoring of callus formation after 12 weeks in propranolol‐treated rats revealed increased callus and bone union. The results of this study indicate that propranolol treatment can significantly affect bone properties.

Original languageEnglish (US)
Pages (from-to)869-875
Number of pages7
JournalJournal of Orthopaedic Research
Volume9
Issue number6
DOIs
StatePublished - Jan 1 1991

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Propranolol
Bone and Bones
Bony Callus
Thigh
Anatomic Models
Bone Matrix
Densitometry
Polyethylene
Osteoblasts
Osteogenesis
Femur
Minerals

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine

Cite this

Minkowitz, B., Boskey, A. L., Lane, J. M., Pearlman, H. S., & Vigorita, V. J. (1991). Effects of propranolol on bone metabolism in the rat. Journal of Orthopaedic Research, 9(6), 869-875. https://doi.org/10.1002/jor.1100090613
Minkowitz, Barbara ; Boskey, Adele L. ; Lane, Joseph M. ; Pearlman, Hubert S. ; Vigorita, Vincent J. / Effects of propranolol on bone metabolism in the rat. In: Journal of Orthopaedic Research. 1991 ; Vol. 9, No. 6. pp. 869-875.
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Minkowitz, B, Boskey, AL, Lane, JM, Pearlman, HS & Vigorita, VJ 1991, 'Effects of propranolol on bone metabolism in the rat', Journal of Orthopaedic Research, vol. 9, no. 6, pp. 869-875. https://doi.org/10.1002/jor.1100090613

Effects of propranolol on bone metabolism in the rat. / Minkowitz, Barbara; Boskey, Adele L.; Lane, Joseph M.; Pearlman, Hubert S.; Vigorita, Vincent J.

In: Journal of Orthopaedic Research, Vol. 9, No. 6, 01.01.1991, p. 869-875.

Research output: Contribution to journalArticle

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