Abstract
Propranolol, a nonspecific β‐blocker, has many physiologic effects. Its effects on bone in vivo are unknown, although β receptor sites have been found on osteoblasts. In this study, the hypothesis tested was that low doses of propranolol could alter bone properties and enhance orthotopic endochondral bone formation. In a group of nonsurgical rats, propranolol treatment increased formation. In a group of nonsurgical rats, propranolol treatment increased femoral torsional strength on biomechanical testing. In the rat surgical model used, right femora were fixed to a polyethylene plate and then defects were created mid‐diaphysis and subsequently filled with demineralized bone matrix. These rats (defect rats) were randomly divided into groups that were given propranolol or a saline carrier for 19 consecutive days. In the defect rats, increased trabecular femoral metaphyseal mineral apposition rates were observed in propranolol‐treated groups. Densitometry and roentgenographic scoring of callus formation after 12 weeks in propranolol‐treated rats revealed increased callus and bone union. The results of this study indicate that propranolol treatment can significantly affect bone properties.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 869-875 |
| Number of pages | 7 |
| Journal | Journal of Orthopaedic Research |
| Volume | 9 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 1991 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Orthopedics and Sports Medicine
Cite this
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Effects of propranolol on bone metabolism in the rat. / Minkowitz, Barbara; Boskey, Adele L.; Lane, Joseph M.; Pearlman, Hubert S.; Vigorita, Vincent J.
In: Journal of Orthopaedic Research, Vol. 9, No. 6, 01.01.1991, p. 869-875.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effects of propranolol on bone metabolism in the rat
AU - Minkowitz, Barbara
AU - Boskey, Adele L.
AU - Lane, Joseph M.
AU - Pearlman, Hubert S.
AU - Vigorita, Vincent J.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - Propranolol, a nonspecific β‐blocker, has many physiologic effects. Its effects on bone in vivo are unknown, although β receptor sites have been found on osteoblasts. In this study, the hypothesis tested was that low doses of propranolol could alter bone properties and enhance orthotopic endochondral bone formation. In a group of nonsurgical rats, propranolol treatment increased formation. In a group of nonsurgical rats, propranolol treatment increased femoral torsional strength on biomechanical testing. In the rat surgical model used, right femora were fixed to a polyethylene plate and then defects were created mid‐diaphysis and subsequently filled with demineralized bone matrix. These rats (defect rats) were randomly divided into groups that were given propranolol or a saline carrier for 19 consecutive days. In the defect rats, increased trabecular femoral metaphyseal mineral apposition rates were observed in propranolol‐treated groups. Densitometry and roentgenographic scoring of callus formation after 12 weeks in propranolol‐treated rats revealed increased callus and bone union. The results of this study indicate that propranolol treatment can significantly affect bone properties.
AB - Propranolol, a nonspecific β‐blocker, has many physiologic effects. Its effects on bone in vivo are unknown, although β receptor sites have been found on osteoblasts. In this study, the hypothesis tested was that low doses of propranolol could alter bone properties and enhance orthotopic endochondral bone formation. In a group of nonsurgical rats, propranolol treatment increased formation. In a group of nonsurgical rats, propranolol treatment increased femoral torsional strength on biomechanical testing. In the rat surgical model used, right femora were fixed to a polyethylene plate and then defects were created mid‐diaphysis and subsequently filled with demineralized bone matrix. These rats (defect rats) were randomly divided into groups that were given propranolol or a saline carrier for 19 consecutive days. In the defect rats, increased trabecular femoral metaphyseal mineral apposition rates were observed in propranolol‐treated groups. Densitometry and roentgenographic scoring of callus formation after 12 weeks in propranolol‐treated rats revealed increased callus and bone union. The results of this study indicate that propranolol treatment can significantly affect bone properties.
UR - http://www.scopus.com/inward/record.url?scp=0025935011&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025935011&partnerID=8YFLogxK
U2 - 10.1002/jor.1100090613
DO - 10.1002/jor.1100090613
M3 - Article
C2 - 1919850
AN - SCOPUS:0025935011
VL - 9
SP - 869
EP - 875
JO - Journal of Orthopaedic Research
JF - Journal of Orthopaedic Research
SN - 0736-0266
IS - 6
ER -