Effects of intraluminal infusion of short-chain fatty acids on the healing of colonic anastomosis in the rat

Rolando Rolandelli, M. J. Koruda, R. G. Settle, J. L. Rombeau

Research output: Contribution to journalArticle

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Abstract

The effects of an intracolonic infusion of short-chain fatty acids (SCFA) on the healing of colonic anastomosis in the rat were investigated. Thirty-three Sprague-Dawley rats underwent transection and anastomosis of the descending colon and transection and diversion of the ascending colon. The proximal limb of the ascending colon was exteriorized as an end colostomy, and the distal (defunctionalized) limb was cannulated for continuous infusion. Rats received either no infusion (N = 11) or an infusion of either electrolytes (N = 11) or SCFA (acetate, propionate, and butyrate; N = 11) into the defunctionalized colonic segment. On the sixth postoperative day bursting pressure (BP) and bowel wall tension (BWT) were determined. The occurrence of spontaneous anastomotic dehiscence was significantly less for the SCFA group (0/11) compared with the no infusion group (5/11, p < 0.01). The anastomotic suture line burst in significantly fewer colons from the SCFA group (1/11) than either the electrolyte infusion (8/11, p < 0.003) or the no infusion (6/6, p < 0.001) groups. BP and BWT were significantly higher for the SCFA group (BP: 147 ± 10 mm Hg; BWT: 59 ± 1.0 dyne 103/cm) than for either the electrolyte (BP: 99 ± 30 mm Hg, p < 0.002; BWT: 45 ± 19, p < 0.03) or no infusion (BP: 111 ± 42, p < 0.02; BWT 36 ± 15, p < 0.007) groups. The results of this study indicate that intracolonic infusion of SCFA resulted in significantly stronger colonic anastomosis in the rat.

Original languageEnglish (US)
Pages (from-to)198-204
Number of pages7
JournalSurgery
Volume100
Issue number2
StatePublished - Jan 1 1986
Externally publishedYes

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Volatile Fatty Acids
Pressure
Electrolytes
Ascending Colon
Extremities
Descending Colon
Colostomy
Butyrates
Propionates
Sutures
Sprague Dawley Rats
Colon
Acetates

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Rolandelli, Rolando ; Koruda, M. J. ; Settle, R. G. ; Rombeau, J. L. / Effects of intraluminal infusion of short-chain fatty acids on the healing of colonic anastomosis in the rat. In: Surgery. 1986 ; Vol. 100, No. 2. pp. 198-204.
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Effects of intraluminal infusion of short-chain fatty acids on the healing of colonic anastomosis in the rat. / Rolandelli, Rolando; Koruda, M. J.; Settle, R. G.; Rombeau, J. L.

In: Surgery, Vol. 100, No. 2, 01.01.1986, p. 198-204.

Research output: Contribution to journalArticle

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T1 - Effects of intraluminal infusion of short-chain fatty acids on the healing of colonic anastomosis in the rat

AU - Rolandelli, Rolando

AU - Koruda, M. J.

AU - Settle, R. G.

AU - Rombeau, J. L.

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N2 - The effects of an intracolonic infusion of short-chain fatty acids (SCFA) on the healing of colonic anastomosis in the rat were investigated. Thirty-three Sprague-Dawley rats underwent transection and anastomosis of the descending colon and transection and diversion of the ascending colon. The proximal limb of the ascending colon was exteriorized as an end colostomy, and the distal (defunctionalized) limb was cannulated for continuous infusion. Rats received either no infusion (N = 11) or an infusion of either electrolytes (N = 11) or SCFA (acetate, propionate, and butyrate; N = 11) into the defunctionalized colonic segment. On the sixth postoperative day bursting pressure (BP) and bowel wall tension (BWT) were determined. The occurrence of spontaneous anastomotic dehiscence was significantly less for the SCFA group (0/11) compared with the no infusion group (5/11, p < 0.01). The anastomotic suture line burst in significantly fewer colons from the SCFA group (1/11) than either the electrolyte infusion (8/11, p < 0.003) or the no infusion (6/6, p < 0.001) groups. BP and BWT were significantly higher for the SCFA group (BP: 147 ± 10 mm Hg; BWT: 59 ± 1.0 dyne 103/cm) than for either the electrolyte (BP: 99 ± 30 mm Hg, p < 0.002; BWT: 45 ± 19, p < 0.03) or no infusion (BP: 111 ± 42, p < 0.02; BWT 36 ± 15, p < 0.007) groups. The results of this study indicate that intracolonic infusion of SCFA resulted in significantly stronger colonic anastomosis in the rat.

AB - The effects of an intracolonic infusion of short-chain fatty acids (SCFA) on the healing of colonic anastomosis in the rat were investigated. Thirty-three Sprague-Dawley rats underwent transection and anastomosis of the descending colon and transection and diversion of the ascending colon. The proximal limb of the ascending colon was exteriorized as an end colostomy, and the distal (defunctionalized) limb was cannulated for continuous infusion. Rats received either no infusion (N = 11) or an infusion of either electrolytes (N = 11) or SCFA (acetate, propionate, and butyrate; N = 11) into the defunctionalized colonic segment. On the sixth postoperative day bursting pressure (BP) and bowel wall tension (BWT) were determined. The occurrence of spontaneous anastomotic dehiscence was significantly less for the SCFA group (0/11) compared with the no infusion group (5/11, p < 0.01). The anastomotic suture line burst in significantly fewer colons from the SCFA group (1/11) than either the electrolyte infusion (8/11, p < 0.003) or the no infusion (6/6, p < 0.001) groups. BP and BWT were significantly higher for the SCFA group (BP: 147 ± 10 mm Hg; BWT: 59 ± 1.0 dyne 103/cm) than for either the electrolyte (BP: 99 ± 30 mm Hg, p < 0.002; BWT: 45 ± 19, p < 0.03) or no infusion (BP: 111 ± 42, p < 0.02; BWT 36 ± 15, p < 0.007) groups. The results of this study indicate that intracolonic infusion of SCFA resulted in significantly stronger colonic anastomosis in the rat.

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