Effect of Parenteral Nutrition Supplemented With Short-Chain Fatty Acids on Adaptation to Massive Small Bowel Resection

Mark J. Koruda, Rolando H. Rolandelli, R. Gregg Settle, Donna M. Zimmaro, John L. Rombeau

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

After massive small bowel resection, total parenteral nutrition (TPN) is prescribed to maintain nutritional status. However, TPN reduces the mass of the remaining intestinal mucosa, whereas adaptation to small bowel resection is associated with increased mucosal mass. Short-chain fatty acids (SCFAs) have been shown to stimulate mucosal cell mitotic activity. This study determined whether the addition of SCFAs to TPN following small bowel resection would prevent intestinal mucosal atrophy produced by TPN. Adult rats underwent an 80% small bowel resection and then received either standard TPN or TPN supplemented with SCFAs (sodium acetate, propionate, and butyrate). After 1 wk, jejunal and ileal mucosal weights, deoxyribonucleic acid, ribonucleic acid, and protein contents were measured and compared with the parameters obtained at the time of resection. Animals receiving TPN showed significant loss of jejunal mucosal weight, deoxyribonucleic acid, ribonucleic acid, and protein and ileal mucosal weight and deoxyribonucleic acid after small bowel resection, whereas animals receiving SCFA-supplemented TPN showed no significant change in the jejunal mucosal parameters and a significant increase in ileal mucosal protein. These data demonstrate that SCFA-supplemented TPN reduces the mucosal atrophy associated with TPN after massive bowel resection and thus may facilitate adaptation to small bowel resection.

Original languageEnglish (US)
Pages (from-to)715-720
Number of pages6
JournalGastroenterology
Volume95
Issue number3
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

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Volatile Fatty Acids
Total Parenteral Nutrition
Parenteral Nutrition
Weights and Measures
Atrophy
DNA
RNA
Sodium Acetate
Proteins
Butyric Acid
Intestinal Mucosa
Nutritional Status

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Koruda, Mark J. ; Rolandelli, Rolando H. ; Settle, R. Gregg ; Zimmaro, Donna M. ; Rombeau, John L. / Effect of Parenteral Nutrition Supplemented With Short-Chain Fatty Acids on Adaptation to Massive Small Bowel Resection. In: Gastroenterology. 1988 ; Vol. 95, No. 3. pp. 715-720.
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Effect of Parenteral Nutrition Supplemented With Short-Chain Fatty Acids on Adaptation to Massive Small Bowel Resection. / Koruda, Mark J.; Rolandelli, Rolando H.; Settle, R. Gregg; Zimmaro, Donna M.; Rombeau, John L.

In: Gastroenterology, Vol. 95, No. 3, 01.01.1988, p. 715-720.

Research output: Contribution to journalArticle

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