Effect of low-grade conductive heating on vascular compliance during in vitro balloon angioplasty

Joseph F. Mitchel, Daniel B. Fram, Thomas A. Aretz, Linda D. Gillam, Charles Woronick, David D. Waters, Raymond G. McKay

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Radiofrequency-powered, thermal balloon angioplasty is a new technique that enhances luminal dilatation with less dissection than conventional angioplasty. The purpose of this study was to assess the effect of radiofrequency heating of balloon fluid on the pressure-volume mechanics of in vitro balloon angioplasty and to determine the histologic basis for thermal-induced compliance changes. In vitro, radiofrequency-powered, thermal balloon angioplasty was performed on 46 paired iliac segments freshly harvested from 23 nonatherosclerotic pigs. Balloon inflations at 60°C were compared to room temperature inflations in paired arterial segments. Intraballoon pressure and volume were recorded during each inflation as volume infusion increased pressure over a 0 to 10 atm range. Pressure-volume compliance curves were plotted for all dilatations. Six segments were stained to assess the histologic abnormalities associated with thermal compliance changes. Radiofrequency heating acutely shifted the pressure-volume curves rightward in 20 of 23 iliac segments compared to nonheated controls. This increase in compliance persisted after heating and exceeded the maximum compliance shift caused by multiple nonheated inflations in a subset of arterial segments. Histologically, heated segments showed increased thinning and compression of the arterial wall, increased medial cell necrosis and altered elastic tissue fibers compared to nonheated specimens. In conclusion, radiofrequency heating of intraballoon fluid to 60°C acutely increases vascular compliance during in vitro balloon angioplasty of nonatherosclerotic iliac arteries. The increased compliance persists after heating and can be greater than the compliance shifts induced by multiple conventional dilatations. Arterial wall thinning and irreversible alteration of elastic tissue fibers probably account for thermal compliance changes.

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
JournalAmerican Heart Journal
Volume128
Issue number1
DOIs
StatePublished - Jul 1994
Externally publishedYes

Fingerprint

Balloon Angioplasty
Heating
Compliance
Blood Vessels
Elastic Tissue
Economic Inflation
Hot Temperature
Pressure
Dilatation
In Vitro Techniques
Iliac Artery
Mechanics
Angioplasty
Dissection
Necrosis
Swine
Temperature

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Mitchel, Joseph F. ; Fram, Daniel B. ; Aretz, Thomas A. ; Gillam, Linda D. ; Woronick, Charles ; Waters, David D. ; McKay, Raymond G. / Effect of low-grade conductive heating on vascular compliance during in vitro balloon angioplasty. In: American Heart Journal. 1994 ; Vol. 128, No. 1. pp. 21-27.
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Effect of low-grade conductive heating on vascular compliance during in vitro balloon angioplasty. / Mitchel, Joseph F.; Fram, Daniel B.; Aretz, Thomas A.; Gillam, Linda D.; Woronick, Charles; Waters, David D.; McKay, Raymond G.

In: American Heart Journal, Vol. 128, No. 1, 07.1994, p. 21-27.

Research output: Contribution to journalArticle

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