Abstract
The detection of distant metastases is critical for prognostication and for the choice of treatment in patients with head and neck squamous cell carcinoma (HNSCC). Pretreatment screening for distant metastases should be conducted particularly for patients with high risk factors, prior to locoregional treatment decisions. Different diagnostic techniques are discussed. Unfortunately, most studies lack sufficient follow-up to reliably assess false-negative results. Moreover, the designs of most studies vary substantially with regard to homogeneity of groups (tumor types and stages), timing (pretreatment, follow-up) and definition of risk factors (patient selection). Therefore, only a few studies are comparable. The combination of F-18 fluoro-d-glucose-positron emission tomography (FDG-PET) and a dedicated CT (at least of the chest) is the most important imaging protocol at the present time. Eventually, whole-body-MRI (WB-MRI) may possibly replace PET-CT for screening patients for distant metastases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 780-786 |
| Number of pages | 7 |
| Journal | Oral Oncology |
| Volume | 48 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2012 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Oral Surgery
- Oncology
- Cancer Research
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}
Distant metastases from head and neck squamous cell carcinoma. Part II. Diagnosis. / De Bree, Remco; Haigentz, Missak; Silver, Carl E.; Paccagnella, Daniela; Hamoir, Marc; Hartl, Dana M.; MacHiels, Jean Pascal; Paleri, Vinidh; Rinaldo, Alessandra; Shaha, Ashok R.; Takes, Robert P.; Leemans, C. René; Ferlito, Alfio.
In: Oral Oncology, Vol. 48, No. 9, 01.09.2012, p. 780-786.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Distant metastases from head and neck squamous cell carcinoma. Part II. Diagnosis
AU - De Bree, Remco
AU - Haigentz, Missak
AU - Silver, Carl E.
AU - Paccagnella, Daniela
AU - Hamoir, Marc
AU - Hartl, Dana M.
AU - MacHiels, Jean Pascal
AU - Paleri, Vinidh
AU - Rinaldo, Alessandra
AU - Shaha, Ashok R.
AU - Takes, Robert P.
AU - Leemans, C. René
AU - Ferlito, Alfio
PY - 2012/9/1
Y1 - 2012/9/1
N2 - The detection of distant metastases is critical for prognostication and for the choice of treatment in patients with head and neck squamous cell carcinoma (HNSCC). Pretreatment screening for distant metastases should be conducted particularly for patients with high risk factors, prior to locoregional treatment decisions. Different diagnostic techniques are discussed. Unfortunately, most studies lack sufficient follow-up to reliably assess false-negative results. Moreover, the designs of most studies vary substantially with regard to homogeneity of groups (tumor types and stages), timing (pretreatment, follow-up) and definition of risk factors (patient selection). Therefore, only a few studies are comparable. The combination of F-18 fluoro-d-glucose-positron emission tomography (FDG-PET) and a dedicated CT (at least of the chest) is the most important imaging protocol at the present time. Eventually, whole-body-MRI (WB-MRI) may possibly replace PET-CT for screening patients for distant metastases.
AB - The detection of distant metastases is critical for prognostication and for the choice of treatment in patients with head and neck squamous cell carcinoma (HNSCC). Pretreatment screening for distant metastases should be conducted particularly for patients with high risk factors, prior to locoregional treatment decisions. Different diagnostic techniques are discussed. Unfortunately, most studies lack sufficient follow-up to reliably assess false-negative results. Moreover, the designs of most studies vary substantially with regard to homogeneity of groups (tumor types and stages), timing (pretreatment, follow-up) and definition of risk factors (patient selection). Therefore, only a few studies are comparable. The combination of F-18 fluoro-d-glucose-positron emission tomography (FDG-PET) and a dedicated CT (at least of the chest) is the most important imaging protocol at the present time. Eventually, whole-body-MRI (WB-MRI) may possibly replace PET-CT for screening patients for distant metastases.
UR - http://www.scopus.com/inward/record.url?scp=84865162276&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865162276&partnerID=8YFLogxK
U2 - 10.1016/j.oraloncology.2012.03.014
DO - 10.1016/j.oraloncology.2012.03.014
M3 - Review article
C2 - 22520053
AN - SCOPUS:84865162276
VL - 48
SP - 780
EP - 786
JO - Oral Oncology
JF - Oral Oncology
SN - 1368-8375
IS - 9
ER -