Distant metastases from head and neck squamous cell carcinoma. Part II. Diagnosis

Remco De Bree, Missak Haigentz, Carl E. Silver, Daniela Paccagnella, Marc Hamoir, Dana M. Hartl, Jean Pascal MacHiels, Vinidh Paleri, Alessandra Rinaldo, Ashok R. Shaha, Robert P. Takes, C. René Leemans, Alfio Ferlito

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

The detection of distant metastases is critical for prognostication and for the choice of treatment in patients with head and neck squamous cell carcinoma (HNSCC). Pretreatment screening for distant metastases should be conducted particularly for patients with high risk factors, prior to locoregional treatment decisions. Different diagnostic techniques are discussed. Unfortunately, most studies lack sufficient follow-up to reliably assess false-negative results. Moreover, the designs of most studies vary substantially with regard to homogeneity of groups (tumor types and stages), timing (pretreatment, follow-up) and definition of risk factors (patient selection). Therefore, only a few studies are comparable. The combination of F-18 fluoro-d-glucose-positron emission tomography (FDG-PET) and a dedicated CT (at least of the chest) is the most important imaging protocol at the present time. Eventually, whole-body-MRI (WB-MRI) may possibly replace PET-CT for screening patients for distant metastases.

Original languageEnglish (US)
Pages (from-to)780-786
Number of pages7
JournalOral Oncology
Volume48
Issue number9
DOIs
StatePublished - Sep 1 2012
Externally publishedYes

Fingerprint

Neoplasm Metastasis
Positron-Emission Tomography
Patient Selection
Thorax
Glucose
Therapeutics
Carcinoma, squamous cell of head and neck
Neoplasms
Positron Emission Tomography Computed Tomography

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Oncology
  • Cancer Research

Cite this

De Bree, R., Haigentz, M., Silver, C. E., Paccagnella, D., Hamoir, M., Hartl, D. M., ... Ferlito, A. (2012). Distant metastases from head and neck squamous cell carcinoma. Part II. Diagnosis. Oral Oncology, 48(9), 780-786. https://doi.org/10.1016/j.oraloncology.2012.03.014
De Bree, Remco ; Haigentz, Missak ; Silver, Carl E. ; Paccagnella, Daniela ; Hamoir, Marc ; Hartl, Dana M. ; MacHiels, Jean Pascal ; Paleri, Vinidh ; Rinaldo, Alessandra ; Shaha, Ashok R. ; Takes, Robert P. ; Leemans, C. René ; Ferlito, Alfio. / Distant metastases from head and neck squamous cell carcinoma. Part II. Diagnosis. In: Oral Oncology. 2012 ; Vol. 48, No. 9. pp. 780-786.
@article{644221bb9d51470194ce7d44c967e9fa,
title = "Distant metastases from head and neck squamous cell carcinoma. Part II. Diagnosis",
abstract = "The detection of distant metastases is critical for prognostication and for the choice of treatment in patients with head and neck squamous cell carcinoma (HNSCC). Pretreatment screening for distant metastases should be conducted particularly for patients with high risk factors, prior to locoregional treatment decisions. Different diagnostic techniques are discussed. Unfortunately, most studies lack sufficient follow-up to reliably assess false-negative results. Moreover, the designs of most studies vary substantially with regard to homogeneity of groups (tumor types and stages), timing (pretreatment, follow-up) and definition of risk factors (patient selection). Therefore, only a few studies are comparable. The combination of F-18 fluoro-d-glucose-positron emission tomography (FDG-PET) and a dedicated CT (at least of the chest) is the most important imaging protocol at the present time. Eventually, whole-body-MRI (WB-MRI) may possibly replace PET-CT for screening patients for distant metastases.",
author = "{De Bree}, Remco and Missak Haigentz and Silver, {Carl E.} and Daniela Paccagnella and Marc Hamoir and Hartl, {Dana M.} and MacHiels, {Jean Pascal} and Vinidh Paleri and Alessandra Rinaldo and Shaha, {Ashok R.} and Takes, {Robert P.} and Leemans, {C. Ren{\'e}} and Alfio Ferlito",
year = "2012",
month = "9",
day = "1",
doi = "10.1016/j.oraloncology.2012.03.014",
language = "English (US)",
volume = "48",
pages = "780--786",
journal = "Oral Oncology",
issn = "1368-8375",
publisher = "Elsevier Limited",
number = "9",

}

De Bree, R, Haigentz, M, Silver, CE, Paccagnella, D, Hamoir, M, Hartl, DM, MacHiels, JP, Paleri, V, Rinaldo, A, Shaha, AR, Takes, RP, Leemans, CR & Ferlito, A 2012, 'Distant metastases from head and neck squamous cell carcinoma. Part II. Diagnosis', Oral Oncology, vol. 48, no. 9, pp. 780-786. https://doi.org/10.1016/j.oraloncology.2012.03.014

Distant metastases from head and neck squamous cell carcinoma. Part II. Diagnosis. / De Bree, Remco; Haigentz, Missak; Silver, Carl E.; Paccagnella, Daniela; Hamoir, Marc; Hartl, Dana M.; MacHiels, Jean Pascal; Paleri, Vinidh; Rinaldo, Alessandra; Shaha, Ashok R.; Takes, Robert P.; Leemans, C. René; Ferlito, Alfio.

In: Oral Oncology, Vol. 48, No. 9, 01.09.2012, p. 780-786.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Distant metastases from head and neck squamous cell carcinoma. Part II. Diagnosis

AU - De Bree, Remco

AU - Haigentz, Missak

AU - Silver, Carl E.

AU - Paccagnella, Daniela

AU - Hamoir, Marc

AU - Hartl, Dana M.

AU - MacHiels, Jean Pascal

AU - Paleri, Vinidh

AU - Rinaldo, Alessandra

AU - Shaha, Ashok R.

AU - Takes, Robert P.

AU - Leemans, C. René

AU - Ferlito, Alfio

PY - 2012/9/1

Y1 - 2012/9/1

N2 - The detection of distant metastases is critical for prognostication and for the choice of treatment in patients with head and neck squamous cell carcinoma (HNSCC). Pretreatment screening for distant metastases should be conducted particularly for patients with high risk factors, prior to locoregional treatment decisions. Different diagnostic techniques are discussed. Unfortunately, most studies lack sufficient follow-up to reliably assess false-negative results. Moreover, the designs of most studies vary substantially with regard to homogeneity of groups (tumor types and stages), timing (pretreatment, follow-up) and definition of risk factors (patient selection). Therefore, only a few studies are comparable. The combination of F-18 fluoro-d-glucose-positron emission tomography (FDG-PET) and a dedicated CT (at least of the chest) is the most important imaging protocol at the present time. Eventually, whole-body-MRI (WB-MRI) may possibly replace PET-CT for screening patients for distant metastases.

AB - The detection of distant metastases is critical for prognostication and for the choice of treatment in patients with head and neck squamous cell carcinoma (HNSCC). Pretreatment screening for distant metastases should be conducted particularly for patients with high risk factors, prior to locoregional treatment decisions. Different diagnostic techniques are discussed. Unfortunately, most studies lack sufficient follow-up to reliably assess false-negative results. Moreover, the designs of most studies vary substantially with regard to homogeneity of groups (tumor types and stages), timing (pretreatment, follow-up) and definition of risk factors (patient selection). Therefore, only a few studies are comparable. The combination of F-18 fluoro-d-glucose-positron emission tomography (FDG-PET) and a dedicated CT (at least of the chest) is the most important imaging protocol at the present time. Eventually, whole-body-MRI (WB-MRI) may possibly replace PET-CT for screening patients for distant metastases.

UR - http://www.scopus.com/inward/record.url?scp=84865162276&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865162276&partnerID=8YFLogxK

U2 - 10.1016/j.oraloncology.2012.03.014

DO - 10.1016/j.oraloncology.2012.03.014

M3 - Review article

C2 - 22520053

AN - SCOPUS:84865162276

VL - 48

SP - 780

EP - 786

JO - Oral Oncology

JF - Oral Oncology

SN - 1368-8375

IS - 9

ER -