Diagnosis and treatment of recurrent laryngeal cancer following initial nonsurgical therapy

Ivan Marcelo Gonçalves Agra, Alfio Ferlito, Robert P. Takes, Carl E. Silver, Kerry D. Olsen, Sandro J. Stoeckli, Primož Strojan, Juan P. Rodrigo, João Gonãalves Filho, Eric M. Genden, Missak Haigentz, Avi Khafif, Randal S. Weber, Peter Zbären, Carlos Suárez, Dana M. Hartl, Alessandra Rinaldo, Kwang Hyun Kim, Luiz P. Kowalski

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Surgery is the preferred modality for curative treatment of recurrent laryngeal cancer after failure of nonsurgical treatments. Patients with initial early-stage cancer experiencing recurrence following radiotherapy often have more advanced-stage tumors by the time the recurrence is recognized. About one third of such recurrent cancers are suitable for conservation surgery. Endoscopic resection with the CO 2 laser or open partial laryngectomy (partial vertical, supracricoid, or supraglottic laryngectomies) have been used. The outcomes of conservation surgery appear better than those after total laryngectomy, because of selection bias. Transoral laser surgery is currently used more frequently than open partial laryngectomy for treatment of early-stage recurrence, with outcomes equivalent to open surgery but with less associated morbidity. Laser surgery has also been employed for selective cases of advanced recurrent disease, but patient selection and expertise are required for application of this modality to rT3 tumors. In general, conservation laryngeal surgery is a safe and effective treatment for localized recurrences after radiotherapy for early-stage glottic cancer. Recurrent advanced-stage cancers should generally be treated by total laryngectomy.

Original languageEnglish (US)
Pages (from-to)727-735
Number of pages9
JournalHead and Neck
Volume34
Issue number5
DOIs
StatePublished - May 1 2012

Fingerprint

Laryngectomy
Laryngeal Neoplasms
Recurrence
Laser Therapy
Neoplasms
Radiotherapy
Tongue Neoplasms
Therapeutics
Selection Bias
Carbon Monoxide
Treatment Failure
Patient Selection
Lasers
Morbidity

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Agra, I. M. G., Ferlito, A., Takes, R. P., Silver, C. E., Olsen, K. D., Stoeckli, S. J., ... Kowalski, L. P. (2012). Diagnosis and treatment of recurrent laryngeal cancer following initial nonsurgical therapy. Head and Neck, 34(5), 727-735. https://doi.org/10.1002/hed.21739
Agra, Ivan Marcelo Gonçalves ; Ferlito, Alfio ; Takes, Robert P. ; Silver, Carl E. ; Olsen, Kerry D. ; Stoeckli, Sandro J. ; Strojan, Primož ; Rodrigo, Juan P. ; Gonãalves Filho, João ; Genden, Eric M. ; Haigentz, Missak ; Khafif, Avi ; Weber, Randal S. ; Zbären, Peter ; Suárez, Carlos ; Hartl, Dana M. ; Rinaldo, Alessandra ; Kim, Kwang Hyun ; Kowalski, Luiz P. / Diagnosis and treatment of recurrent laryngeal cancer following initial nonsurgical therapy. In: Head and Neck. 2012 ; Vol. 34, No. 5. pp. 727-735.
@article{4558b7cc0a394b10a8c0ef3f0a04281c,
title = "Diagnosis and treatment of recurrent laryngeal cancer following initial nonsurgical therapy",
abstract = "Surgery is the preferred modality for curative treatment of recurrent laryngeal cancer after failure of nonsurgical treatments. Patients with initial early-stage cancer experiencing recurrence following radiotherapy often have more advanced-stage tumors by the time the recurrence is recognized. About one third of such recurrent cancers are suitable for conservation surgery. Endoscopic resection with the CO 2 laser or open partial laryngectomy (partial vertical, supracricoid, or supraglottic laryngectomies) have been used. The outcomes of conservation surgery appear better than those after total laryngectomy, because of selection bias. Transoral laser surgery is currently used more frequently than open partial laryngectomy for treatment of early-stage recurrence, with outcomes equivalent to open surgery but with less associated morbidity. Laser surgery has also been employed for selective cases of advanced recurrent disease, but patient selection and expertise are required for application of this modality to rT3 tumors. In general, conservation laryngeal surgery is a safe and effective treatment for localized recurrences after radiotherapy for early-stage glottic cancer. Recurrent advanced-stage cancers should generally be treated by total laryngectomy.",
author = "Agra, {Ivan Marcelo Gon{\cc}alves} and Alfio Ferlito and Takes, {Robert P.} and Silver, {Carl E.} and Olsen, {Kerry D.} and Stoeckli, {Sandro J.} and Primož Strojan and Rodrigo, {Juan P.} and {Gon{\~a}alves Filho}, Jo{\~a}o and Genden, {Eric M.} and Missak Haigentz and Avi Khafif and Weber, {Randal S.} and Peter Zb{\"a}ren and Carlos Su{\'a}rez and Hartl, {Dana M.} and Alessandra Rinaldo and Kim, {Kwang Hyun} and Kowalski, {Luiz P.}",
year = "2012",
month = "5",
day = "1",
doi = "10.1002/hed.21739",
language = "English (US)",
volume = "34",
pages = "727--735",
journal = "Head and Neck",
issn = "1043-3074",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

Agra, IMG, Ferlito, A, Takes, RP, Silver, CE, Olsen, KD, Stoeckli, SJ, Strojan, P, Rodrigo, JP, Gonãalves Filho, J, Genden, EM, Haigentz, M, Khafif, A, Weber, RS, Zbären, P, Suárez, C, Hartl, DM, Rinaldo, A, Kim, KH & Kowalski, LP 2012, 'Diagnosis and treatment of recurrent laryngeal cancer following initial nonsurgical therapy', Head and Neck, vol. 34, no. 5, pp. 727-735. https://doi.org/10.1002/hed.21739

Diagnosis and treatment of recurrent laryngeal cancer following initial nonsurgical therapy. / Agra, Ivan Marcelo Gonçalves; Ferlito, Alfio; Takes, Robert P.; Silver, Carl E.; Olsen, Kerry D.; Stoeckli, Sandro J.; Strojan, Primož; Rodrigo, Juan P.; Gonãalves Filho, João; Genden, Eric M.; Haigentz, Missak; Khafif, Avi; Weber, Randal S.; Zbären, Peter; Suárez, Carlos; Hartl, Dana M.; Rinaldo, Alessandra; Kim, Kwang Hyun; Kowalski, Luiz P.

In: Head and Neck, Vol. 34, No. 5, 01.05.2012, p. 727-735.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Diagnosis and treatment of recurrent laryngeal cancer following initial nonsurgical therapy

AU - Agra, Ivan Marcelo Gonçalves

AU - Ferlito, Alfio

AU - Takes, Robert P.

AU - Silver, Carl E.

AU - Olsen, Kerry D.

AU - Stoeckli, Sandro J.

AU - Strojan, Primož

AU - Rodrigo, Juan P.

AU - Gonãalves Filho, João

AU - Genden, Eric M.

AU - Haigentz, Missak

AU - Khafif, Avi

AU - Weber, Randal S.

AU - Zbären, Peter

AU - Suárez, Carlos

AU - Hartl, Dana M.

AU - Rinaldo, Alessandra

AU - Kim, Kwang Hyun

AU - Kowalski, Luiz P.

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Surgery is the preferred modality for curative treatment of recurrent laryngeal cancer after failure of nonsurgical treatments. Patients with initial early-stage cancer experiencing recurrence following radiotherapy often have more advanced-stage tumors by the time the recurrence is recognized. About one third of such recurrent cancers are suitable for conservation surgery. Endoscopic resection with the CO 2 laser or open partial laryngectomy (partial vertical, supracricoid, or supraglottic laryngectomies) have been used. The outcomes of conservation surgery appear better than those after total laryngectomy, because of selection bias. Transoral laser surgery is currently used more frequently than open partial laryngectomy for treatment of early-stage recurrence, with outcomes equivalent to open surgery but with less associated morbidity. Laser surgery has also been employed for selective cases of advanced recurrent disease, but patient selection and expertise are required for application of this modality to rT3 tumors. In general, conservation laryngeal surgery is a safe and effective treatment for localized recurrences after radiotherapy for early-stage glottic cancer. Recurrent advanced-stage cancers should generally be treated by total laryngectomy.

AB - Surgery is the preferred modality for curative treatment of recurrent laryngeal cancer after failure of nonsurgical treatments. Patients with initial early-stage cancer experiencing recurrence following radiotherapy often have more advanced-stage tumors by the time the recurrence is recognized. About one third of such recurrent cancers are suitable for conservation surgery. Endoscopic resection with the CO 2 laser or open partial laryngectomy (partial vertical, supracricoid, or supraglottic laryngectomies) have been used. The outcomes of conservation surgery appear better than those after total laryngectomy, because of selection bias. Transoral laser surgery is currently used more frequently than open partial laryngectomy for treatment of early-stage recurrence, with outcomes equivalent to open surgery but with less associated morbidity. Laser surgery has also been employed for selective cases of advanced recurrent disease, but patient selection and expertise are required for application of this modality to rT3 tumors. In general, conservation laryngeal surgery is a safe and effective treatment for localized recurrences after radiotherapy for early-stage glottic cancer. Recurrent advanced-stage cancers should generally be treated by total laryngectomy.

UR - http://www.scopus.com/inward/record.url?scp=80053976997&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053976997&partnerID=8YFLogxK

U2 - 10.1002/hed.21739

DO - 10.1002/hed.21739

M3 - Review article

C2 - 21484925

AN - SCOPUS:80053976997

VL - 34

SP - 727

EP - 735

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

IS - 5

ER -

Agra IMG, Ferlito A, Takes RP, Silver CE, Olsen KD, Stoeckli SJ et al. Diagnosis and treatment of recurrent laryngeal cancer following initial nonsurgical therapy. Head and Neck. 2012 May 1;34(5):727-735. https://doi.org/10.1002/hed.21739