Development of synaptic junctions in cerebellar glomeruli

Dennis M.D. Landis, Lori A. Weinstein, John Halperin

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In the glomerular synapses of developing mouse cerebellar cortex, 2 components of the synaptic junctions assemble independently in the immature granule cell dendrites, and then combine, 'Initial' junctions between mossy fiber axons and immature granule cell dendrites have presynaptic and postsynaptic electron-dense fuzz and a widened synaptic cleft, but lack the aggregate of intramembrane particles associated with the extracellular half of the postsynaptic membrane which characterizes mature synaptic junctions. In the vicinity of 'initial junctions' there are particle aggregates which resemble those at mature synaptic junctions, but which are less densely packed and which are not associated with the other features of a junction. The constituent particles of these aggregates move to the sites of 'initial junctions' to combine with them and form 'immature synaptic junctions'. Many of these immature junctions are larger in area than mature synaptic junctions. The immature junctions accumulate a fairly uniform complement of intramembrane particles, which increase in packing density as the junctions decrease in area and attain smaller, adult size.

Original languageEnglish (US)
Pages (from-to)231-245
Number of pages15
JournalDevelopmental Brain Research
Volume8
Issue number2-3
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

Fingerprint

Dendrites
Cerebellar Cortex
Synapses
Axons
Electrons
Membranes

All Science Journal Classification (ASJC) codes

  • Developmental Neuroscience
  • Developmental Biology

Cite this

Landis, Dennis M.D. ; Weinstein, Lori A. ; Halperin, John. / Development of synaptic junctions in cerebellar glomeruli. In: Developmental Brain Research. 1983 ; Vol. 8, No. 2-3. pp. 231-245.
@article{2f13554ced36463683cdaae6e6c38a23,
title = "Development of synaptic junctions in cerebellar glomeruli",
abstract = "In the glomerular synapses of developing mouse cerebellar cortex, 2 components of the synaptic junctions assemble independently in the immature granule cell dendrites, and then combine, 'Initial' junctions between mossy fiber axons and immature granule cell dendrites have presynaptic and postsynaptic electron-dense fuzz and a widened synaptic cleft, but lack the aggregate of intramembrane particles associated with the extracellular half of the postsynaptic membrane which characterizes mature synaptic junctions. In the vicinity of 'initial junctions' there are particle aggregates which resemble those at mature synaptic junctions, but which are less densely packed and which are not associated with the other features of a junction. The constituent particles of these aggregates move to the sites of 'initial junctions' to combine with them and form 'immature synaptic junctions'. Many of these immature junctions are larger in area than mature synaptic junctions. The immature junctions accumulate a fairly uniform complement of intramembrane particles, which increase in packing density as the junctions decrease in area and attain smaller, adult size.",
author = "Landis, {Dennis M.D.} and Weinstein, {Lori A.} and John Halperin",
year = "1983",
month = "1",
day = "1",
doi = "10.1016/0165-3806(83)90008-1",
language = "English (US)",
volume = "8",
pages = "231--245",
journal = "Developmental Brain Research",
issn = "0165-3806",
publisher = "Elsevier BV",
number = "2-3",

}

Development of synaptic junctions in cerebellar glomeruli. / Landis, Dennis M.D.; Weinstein, Lori A.; Halperin, John.

In: Developmental Brain Research, Vol. 8, No. 2-3, 01.01.1983, p. 231-245.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Development of synaptic junctions in cerebellar glomeruli

AU - Landis, Dennis M.D.

AU - Weinstein, Lori A.

AU - Halperin, John

PY - 1983/1/1

Y1 - 1983/1/1

N2 - In the glomerular synapses of developing mouse cerebellar cortex, 2 components of the synaptic junctions assemble independently in the immature granule cell dendrites, and then combine, 'Initial' junctions between mossy fiber axons and immature granule cell dendrites have presynaptic and postsynaptic electron-dense fuzz and a widened synaptic cleft, but lack the aggregate of intramembrane particles associated with the extracellular half of the postsynaptic membrane which characterizes mature synaptic junctions. In the vicinity of 'initial junctions' there are particle aggregates which resemble those at mature synaptic junctions, but which are less densely packed and which are not associated with the other features of a junction. The constituent particles of these aggregates move to the sites of 'initial junctions' to combine with them and form 'immature synaptic junctions'. Many of these immature junctions are larger in area than mature synaptic junctions. The immature junctions accumulate a fairly uniform complement of intramembrane particles, which increase in packing density as the junctions decrease in area and attain smaller, adult size.

AB - In the glomerular synapses of developing mouse cerebellar cortex, 2 components of the synaptic junctions assemble independently in the immature granule cell dendrites, and then combine, 'Initial' junctions between mossy fiber axons and immature granule cell dendrites have presynaptic and postsynaptic electron-dense fuzz and a widened synaptic cleft, but lack the aggregate of intramembrane particles associated with the extracellular half of the postsynaptic membrane which characterizes mature synaptic junctions. In the vicinity of 'initial junctions' there are particle aggregates which resemble those at mature synaptic junctions, but which are less densely packed and which are not associated with the other features of a junction. The constituent particles of these aggregates move to the sites of 'initial junctions' to combine with them and form 'immature synaptic junctions'. Many of these immature junctions are larger in area than mature synaptic junctions. The immature junctions accumulate a fairly uniform complement of intramembrane particles, which increase in packing density as the junctions decrease in area and attain smaller, adult size.

UR - http://www.scopus.com/inward/record.url?scp=0020564592&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020564592&partnerID=8YFLogxK

U2 - 10.1016/0165-3806(83)90008-1

DO - 10.1016/0165-3806(83)90008-1

M3 - Article

C2 - 6871725

AN - SCOPUS:0020564592

VL - 8

SP - 231

EP - 245

JO - Developmental Brain Research

JF - Developmental Brain Research

SN - 0165-3806

IS - 2-3

ER -