Correlation of diffusion-weighted magnetic resonance imaging with neuropathology in Creutzfeldt-Jakob disease

Sanjay Mittal, Peter Farmer, Peter Kalina, Peter B. Kingsley, John Halperin

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Background: Although the diagnosis of Creutzfeld-Jakob disease (CJD) is straightforward in fully developed cases, a definitive diagnosis can be difficult early in the course of the illness. T2-weighted magnetic resonance imaging (MRI) signal abnormalities, and recently, diffusion-weighted MRI abnormalities, have been described in patients with CJD, suggesting the utility of MRI in the early recognition of CJD. Objective: To correlate diffusion-weighted MRI signal abnormalities with neuropathologic changes in CJD. Materials and Methods: Diffusion-weighted MRI and neuropathologic changes of 2 patients with autopsy-proven CJD were examined in a blinded fashion by a neuroradiologist and a neuropathologist. Results: Areas of bright signal on diffusion-weighted MRI correlated with a higher degree of spongiform changes. Conclusion: Diffusion-weighted MRI in CJD demonstrates specific-signal abnormalities that correlate well with areas of the most severe and characteristic neuropathologic changes.

Original languageEnglish (US)
Pages (from-to)128-134
Number of pages7
JournalArchives of Neurology
Volume59
Issue number1
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

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Creutzfeldt-Jakob Syndrome
Diffusion Magnetic Resonance Imaging
Magnetic Resonance Imaging
Neuropathology
Autopsy

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Mittal, Sanjay ; Farmer, Peter ; Kalina, Peter ; Kingsley, Peter B. ; Halperin, John. / Correlation of diffusion-weighted magnetic resonance imaging with neuropathology in Creutzfeldt-Jakob disease. In: Archives of Neurology. 2002 ; Vol. 59, No. 1. pp. 128-134.
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Correlation of diffusion-weighted magnetic resonance imaging with neuropathology in Creutzfeldt-Jakob disease. / Mittal, Sanjay; Farmer, Peter; Kalina, Peter; Kingsley, Peter B.; Halperin, John.

In: Archives of Neurology, Vol. 59, No. 1, 01.01.2002, p. 128-134.

Research output: Contribution to journalArticle

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AB - Background: Although the diagnosis of Creutzfeld-Jakob disease (CJD) is straightforward in fully developed cases, a definitive diagnosis can be difficult early in the course of the illness. T2-weighted magnetic resonance imaging (MRI) signal abnormalities, and recently, diffusion-weighted MRI abnormalities, have been described in patients with CJD, suggesting the utility of MRI in the early recognition of CJD. Objective: To correlate diffusion-weighted MRI signal abnormalities with neuropathologic changes in CJD. Materials and Methods: Diffusion-weighted MRI and neuropathologic changes of 2 patients with autopsy-proven CJD were examined in a blinded fashion by a neuroradiologist and a neuropathologist. Results: Areas of bright signal on diffusion-weighted MRI correlated with a higher degree of spongiform changes. Conclusion: Diffusion-weighted MRI in CJD demonstrates specific-signal abnormalities that correlate well with areas of the most severe and characteristic neuropathologic changes.

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