Coronary artery calcification: Pathogenesis and prognostic implications

Mahesh V. Madhavan, Madhusudhan Tarigopula, Gary S. Mintz, Akiko Maehara, Gregg W. Stone, Philippe Généreux

Research output: Contribution to journalReview article

148 Citations (Scopus)

Abstract

Coronary artery calcification (CAC) is a risk factor for adverse outcomes in the general population and in patients with coronary artery disease. The pathogenesis of CAC and bone formation share common pathways, and risk factors have been identified that contribute to the initiation and progression of CAC. Efforts to control CAC with medical therapy have not been successful. Event-free survival is also reduced in patients with coronary calcification after both percutaneous coronary intervention (PCI) and bypass graft surgery. Although drug-eluting stents and devices for plaque modification have modestly improved outcomes in calcified vessels, adverse event rates are still high. Innovative pharmacologic and device-based approaches are needed to improve the poor prognosis of patients with CAC.

Original languageEnglish (US)
Pages (from-to)1703-1714
Number of pages12
JournalJournal of the American College of Cardiology
Volume63
Issue number17
DOIs
StatePublished - May 6 2014
Externally publishedYes

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Coronary Vessels
Equipment and Supplies
Drug-Eluting Stents
Percutaneous Coronary Intervention
Osteogenesis
Disease-Free Survival
Coronary Artery Disease
Transplants
Population
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Madhavan, Mahesh V. ; Tarigopula, Madhusudhan ; Mintz, Gary S. ; Maehara, Akiko ; Stone, Gregg W. ; Généreux, Philippe. / Coronary artery calcification : Pathogenesis and prognostic implications. In: Journal of the American College of Cardiology. 2014 ; Vol. 63, No. 17. pp. 1703-1714.
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Coronary artery calcification : Pathogenesis and prognostic implications. / Madhavan, Mahesh V.; Tarigopula, Madhusudhan; Mintz, Gary S.; Maehara, Akiko; Stone, Gregg W.; Généreux, Philippe.

In: Journal of the American College of Cardiology, Vol. 63, No. 17, 06.05.2014, p. 1703-1714.

Research output: Contribution to journalReview article

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T1 - Coronary artery calcification

T2 - Pathogenesis and prognostic implications

AU - Madhavan, Mahesh V.

AU - Tarigopula, Madhusudhan

AU - Mintz, Gary S.

AU - Maehara, Akiko

AU - Stone, Gregg W.

AU - Généreux, Philippe

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