Consensus guidelines from the American Society of Peritoneal Surface Malignancies on standardizing the delivery of hyperthermic intraperitoneal chemotherapy (HIPEC) in colorectal cancer patients in the United States

K. Turaga, E. Levine, R. Barone, R. Sticca, N. Petrelli, L. Lambert, G. Nash, M. Morse, R. Adbel-Misih, H. R. Alexander, F. Attiyeh, D. Bartlett, A. Bastidas, T. Blazer, Q. Chu, K. Chung, L. Dominguez-Parra, N. J. Espat, J. Foster, K. Fournier & 23 others R. Garcia, M. Goodman, N. Hanna, Lawrence Harrison, R. Hoefer, M. Holtzman, J. Kane, D. Labow, B. Li, A. Lowy, P. Mansfield, E. Ong, C. Pameijer, J. Pingpank, M. Quinones, R. Royal, G. Salti, A. Sardi, P. Shen, J. Skitzki, J. Spellman, J. Stewart, J. Esquivel

Research output: Contribution to journalArticle

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Abstract

Background: The American Society of Peritoneal Surface Malignancies (ASPSM) is a consortium of cancer centers performing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). This is a position paper from the ASPSM on the standardization of the delivery of HIPEC. Methods: A survey was conducted of all cancer centers performing HIPEC in the United States. We attempted to obtain consensus by the modified method of Delphi on seven key HIPEC parameters: (1) method, (2) inflow temperature, (3) perfusate volume, (4) drug, (5) dosage, (6) timing of drug delivery, and (7) total perfusion time. Statistical analysis was performed using nonparametric tests. Results: Response rates for ASPSM members (n = 45) and non-ASPSM members (n = 24) were 89 and 33 %, respectively. Of the responders from ASPSM members, 95 % agreed with implementing the proposal. Majority of the surgical oncologists favored the closed method of delivery with a standardized dual dose of mitomycin for a 90-min chemoperfusion for patients undergoing cytoreductive surgery for peritoneal carcinomatosis of colorectal origin. Conclusions: This recommendation on a standardized delivery of HIPEC in patients with colorectal cancer represents an important first step in enhancing research in this field. Studies directed at maximizing the efficacy of each of the seven key elements will need to follow.

Original languageEnglish (US)
Pages (from-to)1501-1505
Number of pages5
JournalAnnals of Surgical Oncology
Volume21
Issue number5
DOIs
StatePublished - Jan 1 2014

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Colorectal Neoplasms
Guidelines
Drug Therapy
Neoplasms
Mitomycin
Pharmaceutical Preparations
Perfusion
Carcinoma
Temperature
Research

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Turaga, K. ; Levine, E. ; Barone, R. ; Sticca, R. ; Petrelli, N. ; Lambert, L. ; Nash, G. ; Morse, M. ; Adbel-Misih, R. ; Alexander, H. R. ; Attiyeh, F. ; Bartlett, D. ; Bastidas, A. ; Blazer, T. ; Chu, Q. ; Chung, K. ; Dominguez-Parra, L. ; Espat, N. J. ; Foster, J. ; Fournier, K. ; Garcia, R. ; Goodman, M. ; Hanna, N. ; Harrison, Lawrence ; Hoefer, R. ; Holtzman, M. ; Kane, J. ; Labow, D. ; Li, B. ; Lowy, A. ; Mansfield, P. ; Ong, E. ; Pameijer, C. ; Pingpank, J. ; Quinones, M. ; Royal, R. ; Salti, G. ; Sardi, A. ; Shen, P. ; Skitzki, J. ; Spellman, J. ; Stewart, J. ; Esquivel, J. / Consensus guidelines from the American Society of Peritoneal Surface Malignancies on standardizing the delivery of hyperthermic intraperitoneal chemotherapy (HIPEC) in colorectal cancer patients in the United States. In: Annals of Surgical Oncology. 2014 ; Vol. 21, No. 5. pp. 1501-1505.
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title = "Consensus guidelines from the American Society of Peritoneal Surface Malignancies on standardizing the delivery of hyperthermic intraperitoneal chemotherapy (HIPEC) in colorectal cancer patients in the United States",
abstract = "Background: The American Society of Peritoneal Surface Malignancies (ASPSM) is a consortium of cancer centers performing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). This is a position paper from the ASPSM on the standardization of the delivery of HIPEC. Methods: A survey was conducted of all cancer centers performing HIPEC in the United States. We attempted to obtain consensus by the modified method of Delphi on seven key HIPEC parameters: (1) method, (2) inflow temperature, (3) perfusate volume, (4) drug, (5) dosage, (6) timing of drug delivery, and (7) total perfusion time. Statistical analysis was performed using nonparametric tests. Results: Response rates for ASPSM members (n = 45) and non-ASPSM members (n = 24) were 89 and 33 {\%}, respectively. Of the responders from ASPSM members, 95 {\%} agreed with implementing the proposal. Majority of the surgical oncologists favored the closed method of delivery with a standardized dual dose of mitomycin for a 90-min chemoperfusion for patients undergoing cytoreductive surgery for peritoneal carcinomatosis of colorectal origin. Conclusions: This recommendation on a standardized delivery of HIPEC in patients with colorectal cancer represents an important first step in enhancing research in this field. Studies directed at maximizing the efficacy of each of the seven key elements will need to follow.",
author = "K. Turaga and E. Levine and R. Barone and R. Sticca and N. Petrelli and L. Lambert and G. Nash and M. Morse and R. Adbel-Misih and Alexander, {H. R.} and F. Attiyeh and D. Bartlett and A. Bastidas and T. Blazer and Q. Chu and K. Chung and L. Dominguez-Parra and Espat, {N. J.} and J. Foster and K. Fournier and R. Garcia and M. Goodman and N. Hanna and Lawrence Harrison and R. Hoefer and M. Holtzman and J. Kane and D. Labow and B. Li and A. Lowy and P. Mansfield and E. Ong and C. Pameijer and J. Pingpank and M. Quinones and R. Royal and G. Salti and A. Sardi and P. Shen and J. Skitzki and J. Spellman and J. Stewart and J. Esquivel",
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language = "English (US)",
volume = "21",
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journal = "Annals of Surgical Oncology",
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Turaga, K, Levine, E, Barone, R, Sticca, R, Petrelli, N, Lambert, L, Nash, G, Morse, M, Adbel-Misih, R, Alexander, HR, Attiyeh, F, Bartlett, D, Bastidas, A, Blazer, T, Chu, Q, Chung, K, Dominguez-Parra, L, Espat, NJ, Foster, J, Fournier, K, Garcia, R, Goodman, M, Hanna, N, Harrison, L, Hoefer, R, Holtzman, M, Kane, J, Labow, D, Li, B, Lowy, A, Mansfield, P, Ong, E, Pameijer, C, Pingpank, J, Quinones, M, Royal, R, Salti, G, Sardi, A, Shen, P, Skitzki, J, Spellman, J, Stewart, J & Esquivel, J 2014, 'Consensus guidelines from the American Society of Peritoneal Surface Malignancies on standardizing the delivery of hyperthermic intraperitoneal chemotherapy (HIPEC) in colorectal cancer patients in the United States', Annals of Surgical Oncology, vol. 21, no. 5, pp. 1501-1505. https://doi.org/10.1245/s10434-013-3061-z

Consensus guidelines from the American Society of Peritoneal Surface Malignancies on standardizing the delivery of hyperthermic intraperitoneal chemotherapy (HIPEC) in colorectal cancer patients in the United States. / Turaga, K.; Levine, E.; Barone, R.; Sticca, R.; Petrelli, N.; Lambert, L.; Nash, G.; Morse, M.; Adbel-Misih, R.; Alexander, H. R.; Attiyeh, F.; Bartlett, D.; Bastidas, A.; Blazer, T.; Chu, Q.; Chung, K.; Dominguez-Parra, L.; Espat, N. J.; Foster, J.; Fournier, K.; Garcia, R.; Goodman, M.; Hanna, N.; Harrison, Lawrence; Hoefer, R.; Holtzman, M.; Kane, J.; Labow, D.; Li, B.; Lowy, A.; Mansfield, P.; Ong, E.; Pameijer, C.; Pingpank, J.; Quinones, M.; Royal, R.; Salti, G.; Sardi, A.; Shen, P.; Skitzki, J.; Spellman, J.; Stewart, J.; Esquivel, J.

In: Annals of Surgical Oncology, Vol. 21, No. 5, 01.01.2014, p. 1501-1505.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Consensus guidelines from the American Society of Peritoneal Surface Malignancies on standardizing the delivery of hyperthermic intraperitoneal chemotherapy (HIPEC) in colorectal cancer patients in the United States

AU - Turaga, K.

AU - Levine, E.

AU - Barone, R.

AU - Sticca, R.

AU - Petrelli, N.

AU - Lambert, L.

AU - Nash, G.

AU - Morse, M.

AU - Adbel-Misih, R.

AU - Alexander, H. R.

AU - Attiyeh, F.

AU - Bartlett, D.

AU - Bastidas, A.

AU - Blazer, T.

AU - Chu, Q.

AU - Chung, K.

AU - Dominguez-Parra, L.

AU - Espat, N. J.

AU - Foster, J.

AU - Fournier, K.

AU - Garcia, R.

AU - Goodman, M.

AU - Hanna, N.

AU - Harrison, Lawrence

AU - Hoefer, R.

AU - Holtzman, M.

AU - Kane, J.

AU - Labow, D.

AU - Li, B.

AU - Lowy, A.

AU - Mansfield, P.

AU - Ong, E.

AU - Pameijer, C.

AU - Pingpank, J.

AU - Quinones, M.

AU - Royal, R.

AU - Salti, G.

AU - Sardi, A.

AU - Shen, P.

AU - Skitzki, J.

AU - Spellman, J.

AU - Stewart, J.

AU - Esquivel, J.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: The American Society of Peritoneal Surface Malignancies (ASPSM) is a consortium of cancer centers performing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). This is a position paper from the ASPSM on the standardization of the delivery of HIPEC. Methods: A survey was conducted of all cancer centers performing HIPEC in the United States. We attempted to obtain consensus by the modified method of Delphi on seven key HIPEC parameters: (1) method, (2) inflow temperature, (3) perfusate volume, (4) drug, (5) dosage, (6) timing of drug delivery, and (7) total perfusion time. Statistical analysis was performed using nonparametric tests. Results: Response rates for ASPSM members (n = 45) and non-ASPSM members (n = 24) were 89 and 33 %, respectively. Of the responders from ASPSM members, 95 % agreed with implementing the proposal. Majority of the surgical oncologists favored the closed method of delivery with a standardized dual dose of mitomycin for a 90-min chemoperfusion for patients undergoing cytoreductive surgery for peritoneal carcinomatosis of colorectal origin. Conclusions: This recommendation on a standardized delivery of HIPEC in patients with colorectal cancer represents an important first step in enhancing research in this field. Studies directed at maximizing the efficacy of each of the seven key elements will need to follow.

AB - Background: The American Society of Peritoneal Surface Malignancies (ASPSM) is a consortium of cancer centers performing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). This is a position paper from the ASPSM on the standardization of the delivery of HIPEC. Methods: A survey was conducted of all cancer centers performing HIPEC in the United States. We attempted to obtain consensus by the modified method of Delphi on seven key HIPEC parameters: (1) method, (2) inflow temperature, (3) perfusate volume, (4) drug, (5) dosage, (6) timing of drug delivery, and (7) total perfusion time. Statistical analysis was performed using nonparametric tests. Results: Response rates for ASPSM members (n = 45) and non-ASPSM members (n = 24) were 89 and 33 %, respectively. Of the responders from ASPSM members, 95 % agreed with implementing the proposal. Majority of the surgical oncologists favored the closed method of delivery with a standardized dual dose of mitomycin for a 90-min chemoperfusion for patients undergoing cytoreductive surgery for peritoneal carcinomatosis of colorectal origin. Conclusions: This recommendation on a standardized delivery of HIPEC in patients with colorectal cancer represents an important first step in enhancing research in this field. Studies directed at maximizing the efficacy of each of the seven key elements will need to follow.

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