Cognitive Functioning in Late Lyme Borreliosis

Lauren B. Krupp, David Masur, Joseph Schwartz, Patricia K. Coyle, Lynn J. Langenbach, Susan K. Fernquist, Lina Jandorf, John Halperin

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Lyme borreliosis, a tick-borne multisystem disease, may cause a variety of neurologic complications, including meningoencephalitis and encephalopathy. To evaluate neurobehavioral function following treated Lyme borreliosis, 15 patients with Lyme disease and complaints of persistent cognitive difficulty a mean of 6.7 months following antibiotic treatment underwent neuropsychological evaluation and were compared with 10 healthy controls, matched in aggregate for age and education, who underwent the identical neuropsychological assessment. Compared with controls, patients with Lyme disease exhibited marked impairment on memory tests and particularly on selective reminding measures of memory retrieval. The memory impairment did not correlate with serum or cerebrospinal fluid anti—Borrelia burgdorferi antibody titers and was not explained by magnetic resonance imaging findings or depression. The cause of this encephalopathy is currently unknown; however, indirect effects of systemic infection or other toxic-metabolic factors may be partly responsible.

Original languageEnglish (US)
Pages (from-to)1125-1129
Number of pages5
JournalArchives of Neurology
Volume48
Issue number11
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Lyme Disease
Brain Diseases
Tick-Borne Diseases
Meningoencephalitis
Poisons
Nervous System
Cerebrospinal Fluid
Magnetic Resonance Imaging
Depression
Anti-Bacterial Agents
Education
Lyme Borreliosis
Antibodies
Infection
Serum
Causes
Impairment
Therapeutics

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Krupp, L. B., Masur, D., Schwartz, J., Coyle, P. K., Langenbach, L. J., Fernquist, S. K., ... Halperin, J. (1991). Cognitive Functioning in Late Lyme Borreliosis. Archives of Neurology, 48(11), 1125-1129. https://doi.org/10.1001/archneur.1991.00530230033017
Krupp, Lauren B. ; Masur, David ; Schwartz, Joseph ; Coyle, Patricia K. ; Langenbach, Lynn J. ; Fernquist, Susan K. ; Jandorf, Lina ; Halperin, John. / Cognitive Functioning in Late Lyme Borreliosis. In: Archives of Neurology. 1991 ; Vol. 48, No. 11. pp. 1125-1129.
@article{c775ae2caba740389d7037ba442807fe,
title = "Cognitive Functioning in Late Lyme Borreliosis",
abstract = "Lyme borreliosis, a tick-borne multisystem disease, may cause a variety of neurologic complications, including meningoencephalitis and encephalopathy. To evaluate neurobehavioral function following treated Lyme borreliosis, 15 patients with Lyme disease and complaints of persistent cognitive difficulty a mean of 6.7 months following antibiotic treatment underwent neuropsychological evaluation and were compared with 10 healthy controls, matched in aggregate for age and education, who underwent the identical neuropsychological assessment. Compared with controls, patients with Lyme disease exhibited marked impairment on memory tests and particularly on selective reminding measures of memory retrieval. The memory impairment did not correlate with serum or cerebrospinal fluid anti—Borrelia burgdorferi antibody titers and was not explained by magnetic resonance imaging findings or depression. The cause of this encephalopathy is currently unknown; however, indirect effects of systemic infection or other toxic-metabolic factors may be partly responsible.",
author = "Krupp, {Lauren B.} and David Masur and Joseph Schwartz and Coyle, {Patricia K.} and Langenbach, {Lynn J.} and Fernquist, {Susan K.} and Lina Jandorf and John Halperin",
year = "1991",
month = "1",
day = "1",
doi = "10.1001/archneur.1991.00530230033017",
language = "English (US)",
volume = "48",
pages = "1125--1129",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "11",

}

Krupp, LB, Masur, D, Schwartz, J, Coyle, PK, Langenbach, LJ, Fernquist, SK, Jandorf, L & Halperin, J 1991, 'Cognitive Functioning in Late Lyme Borreliosis', Archives of Neurology, vol. 48, no. 11, pp. 1125-1129. https://doi.org/10.1001/archneur.1991.00530230033017

Cognitive Functioning in Late Lyme Borreliosis. / Krupp, Lauren B.; Masur, David; Schwartz, Joseph; Coyle, Patricia K.; Langenbach, Lynn J.; Fernquist, Susan K.; Jandorf, Lina; Halperin, John.

In: Archives of Neurology, Vol. 48, No. 11, 01.01.1991, p. 1125-1129.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cognitive Functioning in Late Lyme Borreliosis

AU - Krupp, Lauren B.

AU - Masur, David

AU - Schwartz, Joseph

AU - Coyle, Patricia K.

AU - Langenbach, Lynn J.

AU - Fernquist, Susan K.

AU - Jandorf, Lina

AU - Halperin, John

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Lyme borreliosis, a tick-borne multisystem disease, may cause a variety of neurologic complications, including meningoencephalitis and encephalopathy. To evaluate neurobehavioral function following treated Lyme borreliosis, 15 patients with Lyme disease and complaints of persistent cognitive difficulty a mean of 6.7 months following antibiotic treatment underwent neuropsychological evaluation and were compared with 10 healthy controls, matched in aggregate for age and education, who underwent the identical neuropsychological assessment. Compared with controls, patients with Lyme disease exhibited marked impairment on memory tests and particularly on selective reminding measures of memory retrieval. The memory impairment did not correlate with serum or cerebrospinal fluid anti—Borrelia burgdorferi antibody titers and was not explained by magnetic resonance imaging findings or depression. The cause of this encephalopathy is currently unknown; however, indirect effects of systemic infection or other toxic-metabolic factors may be partly responsible.

AB - Lyme borreliosis, a tick-borne multisystem disease, may cause a variety of neurologic complications, including meningoencephalitis and encephalopathy. To evaluate neurobehavioral function following treated Lyme borreliosis, 15 patients with Lyme disease and complaints of persistent cognitive difficulty a mean of 6.7 months following antibiotic treatment underwent neuropsychological evaluation and were compared with 10 healthy controls, matched in aggregate for age and education, who underwent the identical neuropsychological assessment. Compared with controls, patients with Lyme disease exhibited marked impairment on memory tests and particularly on selective reminding measures of memory retrieval. The memory impairment did not correlate with serum or cerebrospinal fluid anti—Borrelia burgdorferi antibody titers and was not explained by magnetic resonance imaging findings or depression. The cause of this encephalopathy is currently unknown; however, indirect effects of systemic infection or other toxic-metabolic factors may be partly responsible.

UR - http://www.scopus.com/inward/record.url?scp=0025787910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025787910&partnerID=8YFLogxK

U2 - 10.1001/archneur.1991.00530230033017

DO - 10.1001/archneur.1991.00530230033017

M3 - Article

VL - 48

SP - 1125

EP - 1129

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 11

ER -

Krupp LB, Masur D, Schwartz J, Coyle PK, Langenbach LJ, Fernquist SK et al. Cognitive Functioning in Late Lyme Borreliosis. Archives of Neurology. 1991 Jan 1;48(11):1125-1129. https://doi.org/10.1001/archneur.1991.00530230033017