Coexistence of lambert-eaton myasthenic syndrome and subacute cerebellar degeneration

Differential effects of treatment

A. M. Blumenfeld, L. D. Recht, D. A. Chad, U. DeGirolami, T. Griffin, Kurt Jaeckle

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

A 61-year-old woman presented with two paraneoplastic neurologic disorders―Lambert-Eaton myasthenic syndrome (LEMS) and sub-acute cerebellar degeneration (SCD)―that antedated the diagnosis of small-cell carcinoma of the lung by 15 months. Plasmapheresis initiated before the identification of the tumor had a beneficial effect on LEMS but did not affect the SCD. Chemotherapy administered for treatment of the primary tumor was also associated with improvement of LEMS but, like plasmapheresis, had no effect on SCD. While the pathogenesis of both LEMS and SCD is thought to be mediated predominantly by humoral immune factors, a differential therapeutic response indicates that mechanisms of tissue damage or susceptibility to tissue injury, or both, differ in these two disorders.

Original languageEnglish (US)
Pages (from-to)1682-1685
Number of pages4
JournalNeurology
Volume41
Issue number10
StatePublished - Jan 1 1991

Fingerprint

Lambert-Eaton Myasthenic Syndrome
Plasmapheresis
Muscle Weakness
Small Cell Lung Carcinoma
Immunologic Factors
Nervous System
Neoplasms
Drug Therapy
Wounds and Injuries
Therapeutics
Subacute cerebellar degeneration

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Blumenfeld, A. M., Recht, L. D., Chad, D. A., DeGirolami, U., Griffin, T., & Jaeckle, K. (1991). Coexistence of lambert-eaton myasthenic syndrome and subacute cerebellar degeneration: Differential effects of treatment. Neurology, 41(10), 1682-1685.
Blumenfeld, A. M. ; Recht, L. D. ; Chad, D. A. ; DeGirolami, U. ; Griffin, T. ; Jaeckle, Kurt. / Coexistence of lambert-eaton myasthenic syndrome and subacute cerebellar degeneration : Differential effects of treatment. In: Neurology. 1991 ; Vol. 41, No. 10. pp. 1682-1685.
@article{7d80c2c528bd4b8baadb3c281f34808e,
title = "Coexistence of lambert-eaton myasthenic syndrome and subacute cerebellar degeneration: Differential effects of treatment",
abstract = "A 61-year-old woman presented with two paraneoplastic neurologic disorders―Lambert-Eaton myasthenic syndrome (LEMS) and sub-acute cerebellar degeneration (SCD)―that antedated the diagnosis of small-cell carcinoma of the lung by 15 months. Plasmapheresis initiated before the identification of the tumor had a beneficial effect on LEMS but did not affect the SCD. Chemotherapy administered for treatment of the primary tumor was also associated with improvement of LEMS but, like plasmapheresis, had no effect on SCD. While the pathogenesis of both LEMS and SCD is thought to be mediated predominantly by humoral immune factors, a differential therapeutic response indicates that mechanisms of tissue damage or susceptibility to tissue injury, or both, differ in these two disorders.",
author = "Blumenfeld, {A. M.} and Recht, {L. D.} and Chad, {D. A.} and U. DeGirolami and T. Griffin and Kurt Jaeckle",
year = "1991",
month = "1",
day = "1",
language = "English (US)",
volume = "41",
pages = "1682--1685",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

Blumenfeld, AM, Recht, LD, Chad, DA, DeGirolami, U, Griffin, T & Jaeckle, K 1991, 'Coexistence of lambert-eaton myasthenic syndrome and subacute cerebellar degeneration: Differential effects of treatment', Neurology, vol. 41, no. 10, pp. 1682-1685.

Coexistence of lambert-eaton myasthenic syndrome and subacute cerebellar degeneration : Differential effects of treatment. / Blumenfeld, A. M.; Recht, L. D.; Chad, D. A.; DeGirolami, U.; Griffin, T.; Jaeckle, Kurt.

In: Neurology, Vol. 41, No. 10, 01.01.1991, p. 1682-1685.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Coexistence of lambert-eaton myasthenic syndrome and subacute cerebellar degeneration

T2 - Differential effects of treatment

AU - Blumenfeld, A. M.

AU - Recht, L. D.

AU - Chad, D. A.

AU - DeGirolami, U.

AU - Griffin, T.

AU - Jaeckle, Kurt

PY - 1991/1/1

Y1 - 1991/1/1

N2 - A 61-year-old woman presented with two paraneoplastic neurologic disorders―Lambert-Eaton myasthenic syndrome (LEMS) and sub-acute cerebellar degeneration (SCD)―that antedated the diagnosis of small-cell carcinoma of the lung by 15 months. Plasmapheresis initiated before the identification of the tumor had a beneficial effect on LEMS but did not affect the SCD. Chemotherapy administered for treatment of the primary tumor was also associated with improvement of LEMS but, like plasmapheresis, had no effect on SCD. While the pathogenesis of both LEMS and SCD is thought to be mediated predominantly by humoral immune factors, a differential therapeutic response indicates that mechanisms of tissue damage or susceptibility to tissue injury, or both, differ in these two disorders.

AB - A 61-year-old woman presented with two paraneoplastic neurologic disorders―Lambert-Eaton myasthenic syndrome (LEMS) and sub-acute cerebellar degeneration (SCD)―that antedated the diagnosis of small-cell carcinoma of the lung by 15 months. Plasmapheresis initiated before the identification of the tumor had a beneficial effect on LEMS but did not affect the SCD. Chemotherapy administered for treatment of the primary tumor was also associated with improvement of LEMS but, like plasmapheresis, had no effect on SCD. While the pathogenesis of both LEMS and SCD is thought to be mediated predominantly by humoral immune factors, a differential therapeutic response indicates that mechanisms of tissue damage or susceptibility to tissue injury, or both, differ in these two disorders.

UR - http://www.scopus.com/inward/record.url?scp=0026010604&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026010604&partnerID=8YFLogxK

M3 - Article

VL - 41

SP - 1682

EP - 1685

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 10

ER -

Blumenfeld AM, Recht LD, Chad DA, DeGirolami U, Griffin T, Jaeckle K. Coexistence of lambert-eaton myasthenic syndrome and subacute cerebellar degeneration: Differential effects of treatment. Neurology. 1991 Jan 1;41(10):1682-1685.