Abstract
Family history of coronary artery disease (CAD) is a well-established risk factor of future cardiovascular events. The authors sought to examine the relationship between family history of CAD and clinical profile and prognosis of patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Materials/Methods: Baseline features and clinical outcomes at 30 days and at 3 years from 3601 patients with STEMI enrolled in the HORIZONS-AMI trial were compared in patients with and without family history of premature CAD, which was present in 1059 patients (29.4%). Results: These patients were younger (median 56.7 vs. 62.1. years, P<. 0.0001) and more often current smokers (52.4% vs. 43.5%, P<. 0.0001), had more dyslipidemia (47.7% vs. 41.1%, P=. 0.0003), less diabetes mellitus (14.1% vs. 17.5%, P=. 0.01) and had shorter symptom onset to balloon times (median 213 vs. 225 min, P=. 0.02). Patients with a family history of premature CAD had higher rates of final TIMI 3 flow (93.8% vs. 90.6%, P=. 0.002), and myocardial blush grade 2 or 3 (83.2% vs. 78.0% P=. 0.0008), and fewer procedural complications. Although the unadjusted 30-day and 3-year mortality rates were lower in patients with a family history of premature CAD (1.8% vs. 3.0%, P=. 0.046 and 4.8% vs. 7.7%, P=. 0.002, respectively), by multivariable analysis the presence of a family history of premature CAD was not an independent predictor of death at 3 years (HR [95%CI]. =. 1.00 [0.70, 1.44], P=. 0.98). Conclusions: A family history of premature CAD is not an independent predictor of higher mortality.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 375-380 |
| Number of pages | 6 |
| Journal | Cardiovascular Revascularization Medicine |
| Volume | 15 |
| Issue number | 8 |
| DOIs | |
| State | Published - Nov 1 2014 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
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Clinical profile and impact of family history of premature coronary artery disease on clinical outcomes of patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction : Analysis from the HORIZONS-AMI Trial. / Ertelt, Konstanze; Généreux, Philippe; Mintz, Gary S.; Brener, Sorin J.; Kirtane, Ajay J.; McAndrew, Thomas C.; Francese, Dominic P.; Ben-Yehuda, Ori; Mehran, Roxana; Stone, Gregg W.
In: Cardiovascular Revascularization Medicine, Vol. 15, No. 8, 01.11.2014, p. 375-380.Research output: Contribution to journal › Article
TY - JOUR
T1 - Clinical profile and impact of family history of premature coronary artery disease on clinical outcomes of patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction
T2 - Analysis from the HORIZONS-AMI Trial
AU - Ertelt, Konstanze
AU - Généreux, Philippe
AU - Mintz, Gary S.
AU - Brener, Sorin J.
AU - Kirtane, Ajay J.
AU - McAndrew, Thomas C.
AU - Francese, Dominic P.
AU - Ben-Yehuda, Ori
AU - Mehran, Roxana
AU - Stone, Gregg W.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Family history of coronary artery disease (CAD) is a well-established risk factor of future cardiovascular events. The authors sought to examine the relationship between family history of CAD and clinical profile and prognosis of patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Materials/Methods: Baseline features and clinical outcomes at 30 days and at 3 years from 3601 patients with STEMI enrolled in the HORIZONS-AMI trial were compared in patients with and without family history of premature CAD, which was present in 1059 patients (29.4%). Results: These patients were younger (median 56.7 vs. 62.1. years, P<. 0.0001) and more often current smokers (52.4% vs. 43.5%, P<. 0.0001), had more dyslipidemia (47.7% vs. 41.1%, P=. 0.0003), less diabetes mellitus (14.1% vs. 17.5%, P=. 0.01) and had shorter symptom onset to balloon times (median 213 vs. 225 min, P=. 0.02). Patients with a family history of premature CAD had higher rates of final TIMI 3 flow (93.8% vs. 90.6%, P=. 0.002), and myocardial blush grade 2 or 3 (83.2% vs. 78.0% P=. 0.0008), and fewer procedural complications. Although the unadjusted 30-day and 3-year mortality rates were lower in patients with a family history of premature CAD (1.8% vs. 3.0%, P=. 0.046 and 4.8% vs. 7.7%, P=. 0.002, respectively), by multivariable analysis the presence of a family history of premature CAD was not an independent predictor of death at 3 years (HR [95%CI]. =. 1.00 [0.70, 1.44], P=. 0.98). Conclusions: A family history of premature CAD is not an independent predictor of higher mortality.
AB - Family history of coronary artery disease (CAD) is a well-established risk factor of future cardiovascular events. The authors sought to examine the relationship between family history of CAD and clinical profile and prognosis of patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Materials/Methods: Baseline features and clinical outcomes at 30 days and at 3 years from 3601 patients with STEMI enrolled in the HORIZONS-AMI trial were compared in patients with and without family history of premature CAD, which was present in 1059 patients (29.4%). Results: These patients were younger (median 56.7 vs. 62.1. years, P<. 0.0001) and more often current smokers (52.4% vs. 43.5%, P<. 0.0001), had more dyslipidemia (47.7% vs. 41.1%, P=. 0.0003), less diabetes mellitus (14.1% vs. 17.5%, P=. 0.01) and had shorter symptom onset to balloon times (median 213 vs. 225 min, P=. 0.02). Patients with a family history of premature CAD had higher rates of final TIMI 3 flow (93.8% vs. 90.6%, P=. 0.002), and myocardial blush grade 2 or 3 (83.2% vs. 78.0% P=. 0.0008), and fewer procedural complications. Although the unadjusted 30-day and 3-year mortality rates were lower in patients with a family history of premature CAD (1.8% vs. 3.0%, P=. 0.046 and 4.8% vs. 7.7%, P=. 0.002, respectively), by multivariable analysis the presence of a family history of premature CAD was not an independent predictor of death at 3 years (HR [95%CI]. =. 1.00 [0.70, 1.44], P=. 0.98). Conclusions: A family history of premature CAD is not an independent predictor of higher mortality.
UR - http://www.scopus.com/inward/record.url?scp=84920515645&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920515645&partnerID=8YFLogxK
U2 - 10.1016/j.carrev.2014.09.002
DO - 10.1016/j.carrev.2014.09.002
M3 - Article
C2 - 25288517
AN - SCOPUS:84920515645
VL - 15
SP - 375
EP - 380
JO - Cardiovascular Revascularization Medicine
JF - Cardiovascular Revascularization Medicine
SN - 1553-8389
IS - 8
ER -