Abstract
Importance of the field: Laryngeal cancer has been the model of curative-intent organ-preserving therapies in clinical oncology. Although the optimal care of patients with laryngeal cancer is truly multidisciplinary, with progressive advances in surgical, radiation, and medical oncology, the development of effective systemic therapies has been a major component of the therapeutic arsenal against laryngeal cancer. Areas covered in this review: This review will discuss the rapidly evolving roles of chemotherapy in the management of locally advanced and metastatic laryngeal cancer. What the reader will gain: The reader will gain a historical perspective on this evolution in treatment and will appreciate current treatment challenges and promising future directions in optimizing therapeutic efficacy in functional larynx preservation and in patient survival. Take home message: The treatment of most patients with laryngeal cancer with systemic therapy represents an opportunity to positively impact functional outcomes with an anatomically and functionally preserved larynx. Future challenges include identification of novel therapies and optimizing therapy protocols for individualized patient care.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1305-1316 |
| Number of pages | 12 |
| Journal | Expert Opinion on Pharmacotherapy |
| Volume | 11 |
| Issue number | 8 |
| DOIs | |
| State | Published - Jun 1 2010 |
| Externally published | Yes |
Fingerprint
All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmacology (medical)
Cite this
}
Chemotherapy regimens and treatment protocols for laryngeal cancer. / Haigentz, Missak; Silver, Carl E.; Hartl, Dana M.; Takes, Robert P.; Rodrigo, Juan P.; Robbins, K. Thomas; Rinaldo, Alessandra; Ferlito, Alfio.
In: Expert Opinion on Pharmacotherapy, Vol. 11, No. 8, 01.06.2010, p. 1305-1316.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Chemotherapy regimens and treatment protocols for laryngeal cancer
AU - Haigentz, Missak
AU - Silver, Carl E.
AU - Hartl, Dana M.
AU - Takes, Robert P.
AU - Rodrigo, Juan P.
AU - Robbins, K. Thomas
AU - Rinaldo, Alessandra
AU - Ferlito, Alfio
PY - 2010/6/1
Y1 - 2010/6/1
N2 - Importance of the field: Laryngeal cancer has been the model of curative-intent organ-preserving therapies in clinical oncology. Although the optimal care of patients with laryngeal cancer is truly multidisciplinary, with progressive advances in surgical, radiation, and medical oncology, the development of effective systemic therapies has been a major component of the therapeutic arsenal against laryngeal cancer. Areas covered in this review: This review will discuss the rapidly evolving roles of chemotherapy in the management of locally advanced and metastatic laryngeal cancer. What the reader will gain: The reader will gain a historical perspective on this evolution in treatment and will appreciate current treatment challenges and promising future directions in optimizing therapeutic efficacy in functional larynx preservation and in patient survival. Take home message: The treatment of most patients with laryngeal cancer with systemic therapy represents an opportunity to positively impact functional outcomes with an anatomically and functionally preserved larynx. Future challenges include identification of novel therapies and optimizing therapy protocols for individualized patient care.
AB - Importance of the field: Laryngeal cancer has been the model of curative-intent organ-preserving therapies in clinical oncology. Although the optimal care of patients with laryngeal cancer is truly multidisciplinary, with progressive advances in surgical, radiation, and medical oncology, the development of effective systemic therapies has been a major component of the therapeutic arsenal against laryngeal cancer. Areas covered in this review: This review will discuss the rapidly evolving roles of chemotherapy in the management of locally advanced and metastatic laryngeal cancer. What the reader will gain: The reader will gain a historical perspective on this evolution in treatment and will appreciate current treatment challenges and promising future directions in optimizing therapeutic efficacy in functional larynx preservation and in patient survival. Take home message: The treatment of most patients with laryngeal cancer with systemic therapy represents an opportunity to positively impact functional outcomes with an anatomically and functionally preserved larynx. Future challenges include identification of novel therapies and optimizing therapy protocols for individualized patient care.
UR - http://www.scopus.com/inward/record.url?scp=77952118528&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952118528&partnerID=8YFLogxK
U2 - 10.1517/14656561003749256
DO - 10.1517/14656561003749256
M3 - Review article
VL - 11
SP - 1305
EP - 1316
JO - Expert Opinion on Pharmacotherapy
JF - Expert Opinion on Pharmacotherapy
SN - 1465-6566
IS - 8
ER -