Cervical lymph node metastases from remote primary tumor sites

Fernando López, Juan P. Rodrigo, Carl E. Silver, Missak Haigentz, Justin A. Bishop, Primož Strojan, Dana M. Hartl, Patrick J. Bradley, William M. Mendenhall, Carlos Suárez, Robert P. Takes, Marc Hamoir, K. Thomas Robbins, Ashok R. Shaha, Jochen A. Werner, Alessandra Rinaldo, Alfio Ferlito

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Although most malignant lymphadenopathy in the neck represent lymphomas or metastases from head and neck primary tumors, occasionally, metastatic disease from remote, usually infraclavicular, sites presents as cervical lymphadenopathy with or without an obvious primary tumor. In general, these tumors metastasize to supraclavicular lymph nodes, but occasionally may present at an isolated higher neck level. A search for the primary tumor includes information gained by histology, immunohistochemistry, and evaluation of molecular markers that may be unique to the primary tumor site. In addition, 18F-fluoro-2-deoxyglocose positron emission tomography combined with CT (FDG-PET/CT) has greatly improved the ability to detect the location of an unknown primary tumor, particularly when in a remote location. Although cervical metastatic disease from a remote primary site is often incurable, there are situations in which meaningful survival can be achieved with appropriate local treatment. Management is quite complex and requires a truly multidisciplinary approach.

Original languageEnglish (US)
Pages (from-to)E2374-E2385
JournalHead and Neck
Volume38
DOIs
StatePublished - Apr 1 2016

Fingerprint

Lymph Nodes
Neoplasm Metastasis
Neck
Neoplasms
Unknown Primary Neoplasms
Positron-Emission Tomography
Lymphoma
Histology
Immunohistochemistry
Head
Lymphadenopathy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

López, F., Rodrigo, J. P., Silver, C. E., Haigentz, M., Bishop, J. A., Strojan, P., ... Ferlito, A. (2016). Cervical lymph node metastases from remote primary tumor sites. Head and Neck, 38, E2374-E2385. https://doi.org/10.1002/hed.24344
López, Fernando ; Rodrigo, Juan P. ; Silver, Carl E. ; Haigentz, Missak ; Bishop, Justin A. ; Strojan, Primož ; Hartl, Dana M. ; Bradley, Patrick J. ; Mendenhall, William M. ; Suárez, Carlos ; Takes, Robert P. ; Hamoir, Marc ; Robbins, K. Thomas ; Shaha, Ashok R. ; Werner, Jochen A. ; Rinaldo, Alessandra ; Ferlito, Alfio. / Cervical lymph node metastases from remote primary tumor sites. In: Head and Neck. 2016 ; Vol. 38. pp. E2374-E2385.
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abstract = "Although most malignant lymphadenopathy in the neck represent lymphomas or metastases from head and neck primary tumors, occasionally, metastatic disease from remote, usually infraclavicular, sites presents as cervical lymphadenopathy with or without an obvious primary tumor. In general, these tumors metastasize to supraclavicular lymph nodes, but occasionally may present at an isolated higher neck level. A search for the primary tumor includes information gained by histology, immunohistochemistry, and evaluation of molecular markers that may be unique to the primary tumor site. In addition, 18F-fluoro-2-deoxyglocose positron emission tomography combined with CT (FDG-PET/CT) has greatly improved the ability to detect the location of an unknown primary tumor, particularly when in a remote location. Although cervical metastatic disease from a remote primary site is often incurable, there are situations in which meaningful survival can be achieved with appropriate local treatment. Management is quite complex and requires a truly multidisciplinary approach.",
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López, F, Rodrigo, JP, Silver, CE, Haigentz, M, Bishop, JA, Strojan, P, Hartl, DM, Bradley, PJ, Mendenhall, WM, Suárez, C, Takes, RP, Hamoir, M, Robbins, KT, Shaha, AR, Werner, JA, Rinaldo, A & Ferlito, A 2016, 'Cervical lymph node metastases from remote primary tumor sites', Head and Neck, vol. 38, pp. E2374-E2385. https://doi.org/10.1002/hed.24344

Cervical lymph node metastases from remote primary tumor sites. / López, Fernando; Rodrigo, Juan P.; Silver, Carl E.; Haigentz, Missak; Bishop, Justin A.; Strojan, Primož; Hartl, Dana M.; Bradley, Patrick J.; Mendenhall, William M.; Suárez, Carlos; Takes, Robert P.; Hamoir, Marc; Robbins, K. Thomas; Shaha, Ashok R.; Werner, Jochen A.; Rinaldo, Alessandra; Ferlito, Alfio.

In: Head and Neck, Vol. 38, 01.04.2016, p. E2374-E2385.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Cervical lymph node metastases from remote primary tumor sites

AU - López, Fernando

AU - Rodrigo, Juan P.

AU - Silver, Carl E.

AU - Haigentz, Missak

AU - Bishop, Justin A.

AU - Strojan, Primož

AU - Hartl, Dana M.

AU - Bradley, Patrick J.

AU - Mendenhall, William M.

AU - Suárez, Carlos

AU - Takes, Robert P.

AU - Hamoir, Marc

AU - Robbins, K. Thomas

AU - Shaha, Ashok R.

AU - Werner, Jochen A.

AU - Rinaldo, Alessandra

AU - Ferlito, Alfio

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Although most malignant lymphadenopathy in the neck represent lymphomas or metastases from head and neck primary tumors, occasionally, metastatic disease from remote, usually infraclavicular, sites presents as cervical lymphadenopathy with or without an obvious primary tumor. In general, these tumors metastasize to supraclavicular lymph nodes, but occasionally may present at an isolated higher neck level. A search for the primary tumor includes information gained by histology, immunohistochemistry, and evaluation of molecular markers that may be unique to the primary tumor site. In addition, 18F-fluoro-2-deoxyglocose positron emission tomography combined with CT (FDG-PET/CT) has greatly improved the ability to detect the location of an unknown primary tumor, particularly when in a remote location. Although cervical metastatic disease from a remote primary site is often incurable, there are situations in which meaningful survival can be achieved with appropriate local treatment. Management is quite complex and requires a truly multidisciplinary approach.

AB - Although most malignant lymphadenopathy in the neck represent lymphomas or metastases from head and neck primary tumors, occasionally, metastatic disease from remote, usually infraclavicular, sites presents as cervical lymphadenopathy with or without an obvious primary tumor. In general, these tumors metastasize to supraclavicular lymph nodes, but occasionally may present at an isolated higher neck level. A search for the primary tumor includes information gained by histology, immunohistochemistry, and evaluation of molecular markers that may be unique to the primary tumor site. In addition, 18F-fluoro-2-deoxyglocose positron emission tomography combined with CT (FDG-PET/CT) has greatly improved the ability to detect the location of an unknown primary tumor, particularly when in a remote location. Although cervical metastatic disease from a remote primary site is often incurable, there are situations in which meaningful survival can be achieved with appropriate local treatment. Management is quite complex and requires a truly multidisciplinary approach.

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López F, Rodrigo JP, Silver CE, Haigentz M, Bishop JA, Strojan P et al. Cervical lymph node metastases from remote primary tumor sites. Head and Neck. 2016 Apr 1;38:E2374-E2385. https://doi.org/10.1002/hed.24344