Anticerebellar antibodies in neurologically normal patients with ovarian neoplasms

H. Robert Brashear, John E. Greenlee, Kurt Jaeckle, John W. Rose

Research output: Contribution to journalArticle

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Abstract

Several groups of investigators have confirmed the occurrence of antibodies to Purkinje and other cerebellar neuronal populations in the serum and spinal fluid of patients with paraneoplastic cerebellar degeneration. Although this antibody response suggests that paraneoplastic cerebellar degeneration may have an autoimmune basis, it is not known what role anticerebellar antibodies play in the pathogenesis of this disorder or whether the presence of antibodies invariably results in cerebellar injury. We identified 3 patients with ovarian malignancies in whom high titers of circulating anticerebellar antibodies were present without clinical evidence of cerebellar disease. We followed these patients clinically and serologically until their deaths from their neoplasms. All 3 patients remained neurologically normal. In 2 of the patients, anticerebellar antibodies persisted at high titer. CSF obtained from 1 of these patients postmortem did not contain detectable levels of anticerebellar antibody, but histopathologic examination of her cerebellum revealed patchy loss of Purkinje cells. In the 3rd patient, antibody titers fell with removal of the primary tumor and chemotherapy but did not rise with tumor recurrence. Indirect immunofluores-cence did not reveal anticerebellar antibodies in the serum or CSF of other patients with neoplasms, patients with other cerebellar disease, or normal controls. The present study demonstrates that patients with ovarian malignancies may occasionally develop antibodies that react with cerebellar neuronal antigens and can maintain this antibody response for protracted periods of time without clinically evident cerebellar injury. Tumor recurrence may not be accompanied by rise in titers of anticerebellar antibodies.

Original languageEnglish (US)
Pages (from-to)1601-1604
Number of pages4
JournalNeurology
Volume39
Issue number12
StatePublished - Jan 1 1989

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Ovarian Neoplasms
Antibodies
Paraneoplastic Cerebellar Degeneration
Neoplasms
Cerebellar Diseases
Antibody Formation
Recurrence
Macrophage Colony-Stimulating Factor
Purkinje Cells
Wounds and Injuries
Serum
Cerebellum
Research Personnel
Antigens
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Brashear, H. R., Greenlee, J. E., Jaeckle, K., & Rose, J. W. (1989). Anticerebellar antibodies in neurologically normal patients with ovarian neoplasms. Neurology, 39(12), 1601-1604.
Brashear, H. Robert ; Greenlee, John E. ; Jaeckle, Kurt ; Rose, John W. / Anticerebellar antibodies in neurologically normal patients with ovarian neoplasms. In: Neurology. 1989 ; Vol. 39, No. 12. pp. 1601-1604.
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Brashear, HR, Greenlee, JE, Jaeckle, K & Rose, JW 1989, 'Anticerebellar antibodies in neurologically normal patients with ovarian neoplasms', Neurology, vol. 39, no. 12, pp. 1601-1604.

Anticerebellar antibodies in neurologically normal patients with ovarian neoplasms. / Brashear, H. Robert; Greenlee, John E.; Jaeckle, Kurt; Rose, John W.

In: Neurology, Vol. 39, No. 12, 01.01.1989, p. 1601-1604.

Research output: Contribution to journalArticle

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Brashear HR, Greenlee JE, Jaeckle K, Rose JW. Anticerebellar antibodies in neurologically normal patients with ovarian neoplasms. Neurology. 1989 Jan 1;39(12):1601-1604.