ANCA-positive vasculitis associated with simvastatin/ezetimibe

Expanding the spectrum of statin-induced autoimmunity?

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Although autoimmune syndromes such as systemic lupus erythematosus and dermatomyositis have been previously reported in association with statin use, vasculitis has not been well described. We present a patient with an antineutrophil cytoplasmic antibody-positive, predominantly cutaneous vasculitis, the temporal course of which was associated with simvastatin/ezetimibe use. The patient's serologic findings were consistent with drug-induced disease, with high titer antimyeloperoxidase, in addition to antinuclear and anti-Ro (SSA) antibodies. The patient demonstrated complete resolution of symptoms simply by withdrawing the drug.

Original languageEnglish (US)
JournalInternational Journal of Rheumatic Diseases
Volume13
Issue number3
DOIs
StatePublished - Aug 1 2010
Externally publishedYes

Fingerprint

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Simvastatin
Autoimmunity
Vasculitis
Antineutrophil Cytoplasmic Antibodies
Dermatomyositis
Pharmaceutical Preparations
Systemic Lupus Erythematosus
Skin
Ezetimibe

All Science Journal Classification (ASJC) codes

  • Rheumatology

Cite this

@article{c2cceea63c284be0a88bd814152ac6a8,
title = "ANCA-positive vasculitis associated with simvastatin/ezetimibe: Expanding the spectrum of statin-induced autoimmunity?",
abstract = "Although autoimmune syndromes such as systemic lupus erythematosus and dermatomyositis have been previously reported in association with statin use, vasculitis has not been well described. We present a patient with an antineutrophil cytoplasmic antibody-positive, predominantly cutaneous vasculitis, the temporal course of which was associated with simvastatin/ezetimibe use. The patient's serologic findings were consistent with drug-induced disease, with high titer antimyeloperoxidase, in addition to antinuclear and anti-Ro (SSA) antibodies. The patient demonstrated complete resolution of symptoms simply by withdrawing the drug.",
author = "Deepali Sen and Elliot Rosenstein and Neil Kramer",
year = "2010",
month = "8",
day = "1",
doi = "10.1111/j.1756-185X.2010.01481.x",
language = "English (US)",
volume = "13",
journal = "International Journal of Rheumatic Diseases",
issn = "1756-1841",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - ANCA-positive vasculitis associated with simvastatin/ezetimibe

T2 - Expanding the spectrum of statin-induced autoimmunity?

AU - Sen, Deepali

AU - Rosenstein, Elliot

AU - Kramer, Neil

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Although autoimmune syndromes such as systemic lupus erythematosus and dermatomyositis have been previously reported in association with statin use, vasculitis has not been well described. We present a patient with an antineutrophil cytoplasmic antibody-positive, predominantly cutaneous vasculitis, the temporal course of which was associated with simvastatin/ezetimibe use. The patient's serologic findings were consistent with drug-induced disease, with high titer antimyeloperoxidase, in addition to antinuclear and anti-Ro (SSA) antibodies. The patient demonstrated complete resolution of symptoms simply by withdrawing the drug.

AB - Although autoimmune syndromes such as systemic lupus erythematosus and dermatomyositis have been previously reported in association with statin use, vasculitis has not been well described. We present a patient with an antineutrophil cytoplasmic antibody-positive, predominantly cutaneous vasculitis, the temporal course of which was associated with simvastatin/ezetimibe use. The patient's serologic findings were consistent with drug-induced disease, with high titer antimyeloperoxidase, in addition to antinuclear and anti-Ro (SSA) antibodies. The patient demonstrated complete resolution of symptoms simply by withdrawing the drug.

UR - http://www.scopus.com/inward/record.url?scp=77955342931&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955342931&partnerID=8YFLogxK

U2 - 10.1111/j.1756-185X.2010.01481.x

DO - 10.1111/j.1756-185X.2010.01481.x

M3 - Article

VL - 13

JO - International Journal of Rheumatic Diseases

JF - International Journal of Rheumatic Diseases

SN - 1756-1841

IS - 3

ER -