Analysis of early out-of hospital mortality after transcatheter aortic valve implantation among patients with aortic stenosis successfully discharged from the hospital and alive at 30 days (from the Placement of Aortic Transcatheter Valves Trial)

Nirat Beohar, Alan Zajarias, Vinod H. Thourani, Howard C. Herrmann, Michael Mack, Samir Kapadia, Philip Green, Suzanne V. Arnold, David J. Cohen, Philippe Genereux, Ke Xu, Martin B. Leon, Ajay J. Kirtane

Research output: Contribution to journalArticle

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Abstract

In high-risk or inoperable patients with severe symptomatic aortic stenosis, transcatheter aortic valve implantation (TAVI) is a proven alternative to standard (i.e., medical) therapy or surgical aortic valve replacement. Concerns have been raised, however, about patients who survive the procedure but have short subsequent survival. The aim of this study was therefore to identify correlates of early out-of-hospital mortality (EOHM) in patients who underwent successful TAVI, rendering TAVI potentially "futile." Patients who were discharged from the hospital and survived >30 days but <12 months after TAVI were identified (the EOHM group). Independent predictors of EOHM were explored, including patient-level factors and procedural nonfatal major complications (NFMCs). A sensitivity analysis was also performed, excluding patients with NFMCs. Among 485 patients who were discharged from the hospital and survived 30 days after TAVI, 101 (21%) were dead within 1 year. Independent predictors of EOHM included serum creatinine, liver disease, coagulopathy, mental status, body mass index, male gender, and Society of Thoracic Surgeons score. Although NFMCs were strongly associated with EOHM, patient-level risk factors for EOHM were similar between patients who did and those who did not experience NFMCs. Compared with standard therapy, TAVI patients with EOHM had similar 6-month 6-minute walk distances and functional classes, with higher rates of repeat hospitalization. In conclusion, in high-risk or inoperable patients who underwent TAVI and were discharged and alive at 30 days, EOHM was not infrequent and was determined largely by presenting characteristics and the occurrence of periprocedural NFMCs. Careful screening and minimization of NFMCs may maximize the benefit of TAVI.

Original languageEnglish (US)
Pages (from-to)1550-1555
Number of pages6
JournalAmerican Journal of Cardiology
Volume114
Issue number10
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Aortic Valve Stenosis
Hospital Mortality
Aortic Valve
Transcatheter Aortic Valve Replacement
Surgical Instruments
Liver Diseases
Creatinine
Hospitalization
Body Mass Index

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Beohar, Nirat ; Zajarias, Alan ; Thourani, Vinod H. ; Herrmann, Howard C. ; Mack, Michael ; Kapadia, Samir ; Green, Philip ; Arnold, Suzanne V. ; Cohen, David J. ; Genereux, Philippe ; Xu, Ke ; Leon, Martin B. ; Kirtane, Ajay J. / Analysis of early out-of hospital mortality after transcatheter aortic valve implantation among patients with aortic stenosis successfully discharged from the hospital and alive at 30 days (from the Placement of Aortic Transcatheter Valves Trial). In: American Journal of Cardiology. 2014 ; Vol. 114, No. 10. pp. 1550-1555.
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Analysis of early out-of hospital mortality after transcatheter aortic valve implantation among patients with aortic stenosis successfully discharged from the hospital and alive at 30 days (from the Placement of Aortic Transcatheter Valves Trial). / Beohar, Nirat; Zajarias, Alan; Thourani, Vinod H.; Herrmann, Howard C.; Mack, Michael; Kapadia, Samir; Green, Philip; Arnold, Suzanne V.; Cohen, David J.; Genereux, Philippe; Xu, Ke; Leon, Martin B.; Kirtane, Ajay J.

In: American Journal of Cardiology, Vol. 114, No. 10, 01.01.2014, p. 1550-1555.

Research output: Contribution to journalArticle

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T1 - Analysis of early out-of hospital mortality after transcatheter aortic valve implantation among patients with aortic stenosis successfully discharged from the hospital and alive at 30 days (from the Placement of Aortic Transcatheter Valves Trial)

AU - Beohar, Nirat

AU - Zajarias, Alan

AU - Thourani, Vinod H.

AU - Herrmann, Howard C.

AU - Mack, Michael

AU - Kapadia, Samir

AU - Green, Philip

AU - Arnold, Suzanne V.

AU - Cohen, David J.

AU - Genereux, Philippe

AU - Xu, Ke

AU - Leon, Martin B.

AU - Kirtane, Ajay J.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - In high-risk or inoperable patients with severe symptomatic aortic stenosis, transcatheter aortic valve implantation (TAVI) is a proven alternative to standard (i.e., medical) therapy or surgical aortic valve replacement. Concerns have been raised, however, about patients who survive the procedure but have short subsequent survival. The aim of this study was therefore to identify correlates of early out-of-hospital mortality (EOHM) in patients who underwent successful TAVI, rendering TAVI potentially "futile." Patients who were discharged from the hospital and survived >30 days but <12 months after TAVI were identified (the EOHM group). Independent predictors of EOHM were explored, including patient-level factors and procedural nonfatal major complications (NFMCs). A sensitivity analysis was also performed, excluding patients with NFMCs. Among 485 patients who were discharged from the hospital and survived 30 days after TAVI, 101 (21%) were dead within 1 year. Independent predictors of EOHM included serum creatinine, liver disease, coagulopathy, mental status, body mass index, male gender, and Society of Thoracic Surgeons score. Although NFMCs were strongly associated with EOHM, patient-level risk factors for EOHM were similar between patients who did and those who did not experience NFMCs. Compared with standard therapy, TAVI patients with EOHM had similar 6-month 6-minute walk distances and functional classes, with higher rates of repeat hospitalization. In conclusion, in high-risk or inoperable patients who underwent TAVI and were discharged and alive at 30 days, EOHM was not infrequent and was determined largely by presenting characteristics and the occurrence of periprocedural NFMCs. Careful screening and minimization of NFMCs may maximize the benefit of TAVI.

AB - In high-risk or inoperable patients with severe symptomatic aortic stenosis, transcatheter aortic valve implantation (TAVI) is a proven alternative to standard (i.e., medical) therapy or surgical aortic valve replacement. Concerns have been raised, however, about patients who survive the procedure but have short subsequent survival. The aim of this study was therefore to identify correlates of early out-of-hospital mortality (EOHM) in patients who underwent successful TAVI, rendering TAVI potentially "futile." Patients who were discharged from the hospital and survived >30 days but <12 months after TAVI were identified (the EOHM group). Independent predictors of EOHM were explored, including patient-level factors and procedural nonfatal major complications (NFMCs). A sensitivity analysis was also performed, excluding patients with NFMCs. Among 485 patients who were discharged from the hospital and survived 30 days after TAVI, 101 (21%) were dead within 1 year. Independent predictors of EOHM included serum creatinine, liver disease, coagulopathy, mental status, body mass index, male gender, and Society of Thoracic Surgeons score. Although NFMCs were strongly associated with EOHM, patient-level risk factors for EOHM were similar between patients who did and those who did not experience NFMCs. Compared with standard therapy, TAVI patients with EOHM had similar 6-month 6-minute walk distances and functional classes, with higher rates of repeat hospitalization. In conclusion, in high-risk or inoperable patients who underwent TAVI and were discharged and alive at 30 days, EOHM was not infrequent and was determined largely by presenting characteristics and the occurrence of periprocedural NFMCs. Careful screening and minimization of NFMCs may maximize the benefit of TAVI.

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