Aerosolized antibiotics in cystic fibrosis: Current and future trends

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Chronic bacteria infection is one of the key challenges in caring for patients with cystic fibrosis (CF). Effective infection control requires appropriate administration of antibiotics. Inhaled antibiotics play a pivotal role in CF management. Pathogens in CF patients target the lumen of the lung, a cavity that is difficult to access via the oral or intravenous route. Aerosolized antibiotics deliver effective local drug concentrations to the infection site and decrease the risk of systemic side effects associated with oral or intravenous antibiotics. However, effective aerosolized antibiotic therapy must ensure reliable drug delivery to the lower respiratory tract with a beneficial pharmacodynamic profile and high potency.

Original languageEnglish (US)
Pages (from-to)479-487
Number of pages9
JournalExpert Review of Respiratory Medicine
Volume2
Issue number4
DOIs
StatePublished - Aug 1 2008
Externally publishedYes

Fingerprint

Cystic Fibrosis
Anti-Bacterial Agents
Infection Control
Infection
Pharmaceutical Preparations
Respiratory System
Bacteria
Lung
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health

Cite this

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Aerosolized antibiotics in cystic fibrosis : Current and future trends. / Fiel, Stanley B.

In: Expert Review of Respiratory Medicine, Vol. 2, No. 4, 01.08.2008, p. 479-487.

Research output: Contribution to journalReview article

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