Adipose tissue immune response

Novel triggers and consequences for chronic inflammatory conditions

Giorgio Ghigliotti, Chiara Barisione, Silvano Garibaldi, Patrizia Fabbi, Claudio Brunelli, Paolo Spallarossa, Paola Altieri, Gianmarco Rosa, Giovanni Spinella, Domenico Palombo, Razvan Arsenescu, Violeta Arsenescu

Research output: Contribution to journalReview article

87 Citations (Scopus)

Abstract

Adipose tissue inflammation mediates the association between excessive body fat accumulation and several chronic inflammatory diseases. A high prevalence of obesity-associated adipose tissue inflammation was observed not only in patients with cardiovascular conditions but also in patients with inflammatory bowel diseases, abdominal aortic aneurysm, or cardiorenal syndrome. In addition to excessive caloric intake, other triggers promote visceral adipose tissue inflammation followed by chronic, low-grade systemic inflammation. The infiltration and accumulation of immune cells in the inflamed and hypertrophied adipose tissue promote the production of inflammatory cytokines, contributing to target organ damages. This comorbidity seems to delimit subgroups of individuals with systemic adipose tissue inflammation and more severe chronic inflammatory diseases that are refractory to conventional treatment. This review highlights the association between adipose tissue immune response and the pathophysiology of visceral adiposity-related chronic inflammatory diseases, while suggesting several new therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)1337-1353
Number of pages17
JournalInflammation
Volume37
Issue number4
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Adipose Tissue
Inflammation
Chronic Disease
Cardio-Renal Syndrome
Intra-Abdominal Fat
Abdominal Aortic Aneurysm
Adiposity
Energy Intake
Inflammatory Bowel Diseases
Comorbidity
Obesity
Cytokines
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Ghigliotti, G., Barisione, C., Garibaldi, S., Fabbi, P., Brunelli, C., Spallarossa, P., ... Arsenescu, V. (2014). Adipose tissue immune response: Novel triggers and consequences for chronic inflammatory conditions. Inflammation, 37(4), 1337-1353. https://doi.org/10.1007/s10753-014-9914-1
Ghigliotti, Giorgio ; Barisione, Chiara ; Garibaldi, Silvano ; Fabbi, Patrizia ; Brunelli, Claudio ; Spallarossa, Paolo ; Altieri, Paola ; Rosa, Gianmarco ; Spinella, Giovanni ; Palombo, Domenico ; Arsenescu, Razvan ; Arsenescu, Violeta. / Adipose tissue immune response : Novel triggers and consequences for chronic inflammatory conditions. In: Inflammation. 2014 ; Vol. 37, No. 4. pp. 1337-1353.
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Ghigliotti, G, Barisione, C, Garibaldi, S, Fabbi, P, Brunelli, C, Spallarossa, P, Altieri, P, Rosa, G, Spinella, G, Palombo, D, Arsenescu, R & Arsenescu, V 2014, 'Adipose tissue immune response: Novel triggers and consequences for chronic inflammatory conditions', Inflammation, vol. 37, no. 4, pp. 1337-1353. https://doi.org/10.1007/s10753-014-9914-1

Adipose tissue immune response : Novel triggers and consequences for chronic inflammatory conditions. / Ghigliotti, Giorgio; Barisione, Chiara; Garibaldi, Silvano; Fabbi, Patrizia; Brunelli, Claudio; Spallarossa, Paolo; Altieri, Paola; Rosa, Gianmarco; Spinella, Giovanni; Palombo, Domenico; Arsenescu, Razvan; Arsenescu, Violeta.

In: Inflammation, Vol. 37, No. 4, 01.01.2014, p. 1337-1353.

Research output: Contribution to journalReview article

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AU - Ghigliotti, Giorgio

AU - Barisione, Chiara

AU - Garibaldi, Silvano

AU - Fabbi, Patrizia

AU - Brunelli, Claudio

AU - Spallarossa, Paolo

AU - Altieri, Paola

AU - Rosa, Gianmarco

AU - Spinella, Giovanni

AU - Palombo, Domenico

AU - Arsenescu, Razvan

AU - Arsenescu, Violeta

PY - 2014/1/1

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Ghigliotti G, Barisione C, Garibaldi S, Fabbi P, Brunelli C, Spallarossa P et al. Adipose tissue immune response: Novel triggers and consequences for chronic inflammatory conditions. Inflammation. 2014 Jan 1;37(4):1337-1353. https://doi.org/10.1007/s10753-014-9914-1