Adenoid cystic carcinoma of the head and neck - An update

Andrés Coca-Pelaz, Juan P. Rodrigo, Patrick J. Bradley, Vincent Vander Poorten, Asterios Triantafyllou, Jennifer L. Hunt, Primož Strojan, Alessandra Rinaldo, Missak Haigentz, Robert P. Takes, Vanni Mondin, Afshin Teymoortash, Lester D.R. Thompson, Alfio Ferlito

Research output: Contribution to journalReview article

110 Citations (Scopus)

Abstract

This article provides an update on the current understanding of adenoid cystic carcinoma of the head and neck, including a review of its epidemiology, clinical behavior, pathology, molecular biology, diagnostic workup, treatment and prognosis. Adenoid cystic carcinoma is an uncommon salivary gland tumor that may arise in a wide variety of anatomical sites in the head and neck, often with an advanced stage at diagnosis. The clinical course is characterized by very late recurrences; consequently, clinical follow-up should extend at least >15 years. The optimal treatment is generally considered to be surgery with postoperative radiotherapy to optimize local disease control. Much effort has been invested into understanding the tumor's molecular biological processes, aiming to identify patients at high risk of recurrence, in hopes that they could benefit from other, still unproven treatment modalities such as chemotherapy or biological therapy.

Original languageEnglish (US)
Pages (from-to)652-661
Number of pages10
JournalOral Oncology
Volume51
Issue number7
DOIs
StatePublished - Jul 1 2015
Externally publishedYes

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Adenoid Cystic Carcinoma
Neck
Head
Biological Phenomena
Recurrence
Biological Therapy
Clinical Pathology
Glandular and Epithelial Neoplasms
Molecular Pathology
Molecular Biology
Epidemiology
Radiotherapy
Therapeutics
Drug Therapy
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Oncology
  • Cancer Research

Cite this

Coca-Pelaz, A., Rodrigo, J. P., Bradley, P. J., Vander Poorten, V., Triantafyllou, A., Hunt, J. L., ... Ferlito, A. (2015). Adenoid cystic carcinoma of the head and neck - An update. Oral Oncology, 51(7), 652-661. https://doi.org/10.1016/j.oraloncology.2015.04.005
Coca-Pelaz, Andrés ; Rodrigo, Juan P. ; Bradley, Patrick J. ; Vander Poorten, Vincent ; Triantafyllou, Asterios ; Hunt, Jennifer L. ; Strojan, Primož ; Rinaldo, Alessandra ; Haigentz, Missak ; Takes, Robert P. ; Mondin, Vanni ; Teymoortash, Afshin ; Thompson, Lester D.R. ; Ferlito, Alfio. / Adenoid cystic carcinoma of the head and neck - An update. In: Oral Oncology. 2015 ; Vol. 51, No. 7. pp. 652-661.
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Coca-Pelaz, A, Rodrigo, JP, Bradley, PJ, Vander Poorten, V, Triantafyllou, A, Hunt, JL, Strojan, P, Rinaldo, A, Haigentz, M, Takes, RP, Mondin, V, Teymoortash, A, Thompson, LDR & Ferlito, A 2015, 'Adenoid cystic carcinoma of the head and neck - An update', Oral Oncology, vol. 51, no. 7, pp. 652-661. https://doi.org/10.1016/j.oraloncology.2015.04.005

Adenoid cystic carcinoma of the head and neck - An update. / Coca-Pelaz, Andrés; Rodrigo, Juan P.; Bradley, Patrick J.; Vander Poorten, Vincent; Triantafyllou, Asterios; Hunt, Jennifer L.; Strojan, Primož; Rinaldo, Alessandra; Haigentz, Missak; Takes, Robert P.; Mondin, Vanni; Teymoortash, Afshin; Thompson, Lester D.R.; Ferlito, Alfio.

In: Oral Oncology, Vol. 51, No. 7, 01.07.2015, p. 652-661.

Research output: Contribution to journalReview article

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AU - Coca-Pelaz, Andrés

AU - Rodrigo, Juan P.

AU - Bradley, Patrick J.

AU - Vander Poorten, Vincent

AU - Triantafyllou, Asterios

AU - Hunt, Jennifer L.

AU - Strojan, Primož

AU - Rinaldo, Alessandra

AU - Haigentz, Missak

AU - Takes, Robert P.

AU - Mondin, Vanni

AU - Teymoortash, Afshin

AU - Thompson, Lester D.R.

AU - Ferlito, Alfio

PY - 2015/7/1

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AB - This article provides an update on the current understanding of adenoid cystic carcinoma of the head and neck, including a review of its epidemiology, clinical behavior, pathology, molecular biology, diagnostic workup, treatment and prognosis. Adenoid cystic carcinoma is an uncommon salivary gland tumor that may arise in a wide variety of anatomical sites in the head and neck, often with an advanced stage at diagnosis. The clinical course is characterized by very late recurrences; consequently, clinical follow-up should extend at least >15 years. The optimal treatment is generally considered to be surgery with postoperative radiotherapy to optimize local disease control. Much effort has been invested into understanding the tumor's molecular biological processes, aiming to identify patients at high risk of recurrence, in hopes that they could benefit from other, still unproven treatment modalities such as chemotherapy or biological therapy.

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Coca-Pelaz A, Rodrigo JP, Bradley PJ, Vander Poorten V, Triantafyllou A, Hunt JL et al. Adenoid cystic carcinoma of the head and neck - An update. Oral Oncology. 2015 Jul 1;51(7):652-661. https://doi.org/10.1016/j.oraloncology.2015.04.005