A histomorphometric and histologic analysis of the implant interface in five successful, autopsy-retrieved, noncemented porous-coated knee arthroplasties

V. J. Vigorita, B. Minkowitz, J. F. Dichiara, P. A. Higham

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Five clinically successful, primary uncemented porous-coated anatomic knee implants were retrieved postmortem, 13-56 months after implantation, and were sectioned and evaluated histologically and histomorphometrically for bone ingrowth. The prosthesis-bone interface was divided into the following four zones: (1) the tissue prosthetic surface interface; (2) the beaded area; (3) the immediate beadless area; and (4) the marrow space. Although fibroosseous ingrowth was present in all cases, it varied quantitatively with each case and component. Average component bone ingrowth for the prosthesis interface (Zones 1 and 2) of patellae was 29%; tibias, 6%; and femora, 8%. In Zone 3, the percentage of bone apposed to the prosthesis for the patellae was 53%; tibias 36%; and femora, 32%. Zone 4, the marrow space, was not quantitated. The fibrous tissue filling nonbone-ingrown porous space in Zone 2 appeared 'ligamentoid,' connecting bone to beads within Zone 2 and between Zones 2 and 3. Zone 3 exhibited a bony plate formation parallel to the prostheses. No significant inflammation was noted. Overall there was more bone ingrowth into Zone 3 than Zones 1 and 2 with greater bone ingrowth found in the patellar components. The implant interface in clinically successful noncemented porous-coated prostheses of this design is characterized histologically by a noninflammatory fibroosseous ingrowth of varying degrees, and the fibrous component of this composite structure exhibits a highly organized pattern.

Original languageEnglish (US)
Pages (from-to)211-218
Number of pages8
JournalClinical Orthopaedics and Related Research
Issue number293
StatePublished - Jan 1 1993
Externally publishedYes

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Knee Replacement Arthroplasties
Autopsy
Bone and Bones
Patella
Tibia
Femur
Prostheses and Implants
Bone Marrow
Prosthesis Design
Knee
Inflammation

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

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title = "A histomorphometric and histologic analysis of the implant interface in five successful, autopsy-retrieved, noncemented porous-coated knee arthroplasties",
abstract = "Five clinically successful, primary uncemented porous-coated anatomic knee implants were retrieved postmortem, 13-56 months after implantation, and were sectioned and evaluated histologically and histomorphometrically for bone ingrowth. The prosthesis-bone interface was divided into the following four zones: (1) the tissue prosthetic surface interface; (2) the beaded area; (3) the immediate beadless area; and (4) the marrow space. Although fibroosseous ingrowth was present in all cases, it varied quantitatively with each case and component. Average component bone ingrowth for the prosthesis interface (Zones 1 and 2) of patellae was 29{\%}; tibias, 6{\%}; and femora, 8{\%}. In Zone 3, the percentage of bone apposed to the prosthesis for the patellae was 53{\%}; tibias 36{\%}; and femora, 32{\%}. Zone 4, the marrow space, was not quantitated. The fibrous tissue filling nonbone-ingrown porous space in Zone 2 appeared 'ligamentoid,' connecting bone to beads within Zone 2 and between Zones 2 and 3. Zone 3 exhibited a bony plate formation parallel to the prostheses. No significant inflammation was noted. Overall there was more bone ingrowth into Zone 3 than Zones 1 and 2 with greater bone ingrowth found in the patellar components. The implant interface in clinically successful noncemented porous-coated prostheses of this design is characterized histologically by a noninflammatory fibroosseous ingrowth of varying degrees, and the fibrous component of this composite structure exhibits a highly organized pattern.",
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A histomorphometric and histologic analysis of the implant interface in five successful, autopsy-retrieved, noncemented porous-coated knee arthroplasties. / Vigorita, V. J.; Minkowitz, B.; Dichiara, J. F.; Higham, P. A.

In: Clinical Orthopaedics and Related Research, No. 293, 01.01.1993, p. 211-218.

Research output: Contribution to journalArticle

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