A critical appraisal of "chronic lyme disease"

Henry M. Feder, Barbara J.B. Johnson, Susan O'Connell, Eugene D. Shapiro, Allen C. Steere, Gary P. Wormser, W. A. Agger, H. Artsob, P. Auwaerter, J. S. Dumler, J. S. Bakken, L. K. Bockenstedt, J. Green, R. J. Dattwyler, J. Munoz, R. B. Nadelman, I. Schwartz, T. Draper, E. McSweegan, John Halperin & 11 others M. S. Klempner, P. J. Krause, P. Mead, M. Morshed, R. Porwancher, J. D. Radolf, R. P. Smith, S. Sood, A. Weinstein, S. J. Wong, L. Zemel

Research output: Contribution to journalReview article

346 Citations (Scopus)

Abstract

"Chronic Lyme disease" is often used to explain persistent pain, fatigue, and neurocognitive symptoms in patients without any evidence of previous acute Lyme disease. Once this diagnosis is given, prolonged treatment with multiple antimicrobial agents may follow. This review examines the scientific evidence for chronic borrelia infection and explains the approach to clinical evaluation and management in patients with a diagnosis of chronic Lyme disease.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Volume357
Issue number14
DOIs
StatePublished - Oct 4 2007
Externally publishedYes

Fingerprint

Lyme Disease
Chronic Disease
Borrelia Infections
Acute Disease
Anti-Infective Agents
Fatigue
Pain
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Feder, H. M., Johnson, B. J. B., O'Connell, S., Shapiro, E. D., Steere, A. C., Wormser, G. P., ... Zemel, L. (2007). A critical appraisal of "chronic lyme disease". New England Journal of Medicine, 357(14). https://doi.org/10.1056/NEJMra072023
Feder, Henry M. ; Johnson, Barbara J.B. ; O'Connell, Susan ; Shapiro, Eugene D. ; Steere, Allen C. ; Wormser, Gary P. ; Agger, W. A. ; Artsob, H. ; Auwaerter, P. ; Dumler, J. S. ; Bakken, J. S. ; Bockenstedt, L. K. ; Green, J. ; Dattwyler, R. J. ; Munoz, J. ; Nadelman, R. B. ; Schwartz, I. ; Draper, T. ; McSweegan, E. ; Halperin, John ; Klempner, M. S. ; Krause, P. J. ; Mead, P. ; Morshed, M. ; Porwancher, R. ; Radolf, J. D. ; Smith, R. P. ; Sood, S. ; Weinstein, A. ; Wong, S. J. ; Zemel, L. / A critical appraisal of "chronic lyme disease". In: New England Journal of Medicine. 2007 ; Vol. 357, No. 14.
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Feder, HM, Johnson, BJB, O'Connell, S, Shapiro, ED, Steere, AC, Wormser, GP, Agger, WA, Artsob, H, Auwaerter, P, Dumler, JS, Bakken, JS, Bockenstedt, LK, Green, J, Dattwyler, RJ, Munoz, J, Nadelman, RB, Schwartz, I, Draper, T, McSweegan, E, Halperin, J, Klempner, MS, Krause, PJ, Mead, P, Morshed, M, Porwancher, R, Radolf, JD, Smith, RP, Sood, S, Weinstein, A, Wong, SJ & Zemel, L 2007, 'A critical appraisal of "chronic lyme disease"', New England Journal of Medicine, vol. 357, no. 14. https://doi.org/10.1056/NEJMra072023

A critical appraisal of "chronic lyme disease". / Feder, Henry M.; Johnson, Barbara J.B.; O'Connell, Susan; Shapiro, Eugene D.; Steere, Allen C.; Wormser, Gary P.; Agger, W. A.; Artsob, H.; Auwaerter, P.; Dumler, J. S.; Bakken, J. S.; Bockenstedt, L. K.; Green, J.; Dattwyler, R. J.; Munoz, J.; Nadelman, R. B.; Schwartz, I.; Draper, T.; McSweegan, E.; Halperin, John; Klempner, M. S.; Krause, P. J.; Mead, P.; Morshed, M.; Porwancher, R.; Radolf, J. D.; Smith, R. P.; Sood, S.; Weinstein, A.; Wong, S. J.; Zemel, L.

In: New England Journal of Medicine, Vol. 357, No. 14, 04.10.2007.

Research output: Contribution to journalReview article

TY - JOUR

T1 - A critical appraisal of "chronic lyme disease"

AU - Feder, Henry M.

AU - Johnson, Barbara J.B.

AU - O'Connell, Susan

AU - Shapiro, Eugene D.

AU - Steere, Allen C.

AU - Wormser, Gary P.

AU - Agger, W. A.

AU - Artsob, H.

AU - Auwaerter, P.

AU - Dumler, J. S.

AU - Bakken, J. S.

AU - Bockenstedt, L. K.

AU - Green, J.

AU - Dattwyler, R. J.

AU - Munoz, J.

AU - Nadelman, R. B.

AU - Schwartz, I.

AU - Draper, T.

AU - McSweegan, E.

AU - Halperin, John

AU - Klempner, M. S.

AU - Krause, P. J.

AU - Mead, P.

AU - Morshed, M.

AU - Porwancher, R.

AU - Radolf, J. D.

AU - Smith, R. P.

AU - Sood, S.

AU - Weinstein, A.

AU - Wong, S. J.

AU - Zemel, L.

PY - 2007/10/4

Y1 - 2007/10/4

N2 - "Chronic Lyme disease" is often used to explain persistent pain, fatigue, and neurocognitive symptoms in patients without any evidence of previous acute Lyme disease. Once this diagnosis is given, prolonged treatment with multiple antimicrobial agents may follow. This review examines the scientific evidence for chronic borrelia infection and explains the approach to clinical evaluation and management in patients with a diagnosis of chronic Lyme disease.

AB - "Chronic Lyme disease" is often used to explain persistent pain, fatigue, and neurocognitive symptoms in patients without any evidence of previous acute Lyme disease. Once this diagnosis is given, prolonged treatment with multiple antimicrobial agents may follow. This review examines the scientific evidence for chronic borrelia infection and explains the approach to clinical evaluation and management in patients with a diagnosis of chronic Lyme disease.

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U2 - 10.1056/NEJMra072023

DO - 10.1056/NEJMra072023

M3 - Review article

VL - 357

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 14

ER -

Feder HM, Johnson BJB, O'Connell S, Shapiro ED, Steere AC, Wormser GP et al. A critical appraisal of "chronic lyme disease". New England Journal of Medicine. 2007 Oct 4;357(14). https://doi.org/10.1056/NEJMra072023