Research Output 1992 2019

2019
1 Citation (Scopus)

Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis

Haberman, Y., Schirmer, M., Dexheimer, P. J., Karns, R., Braun, T., Kim, M. O., Walters, T. D., Baldassano, R. N., Noe, J. D., Rosh, J., Markowitz, J., Crandall, W. V., Mack, D. R., Griffiths, A. M., Heyman, M. B., Baker, S. S., Kellermayer, R., Moulton, D., Patel, A. S., Gulati, A. S. & 18 othersSteiner, S. J., LeLeiko, N., Otley, A., Oliva-Hemker, M., Ziring, D., Kirschner, B. S., Keljo, D. J., Guthery, S. L., Cohen, S. A., Snapper, S., Evans, J., Dubinsky, M., Aronow, B., Hyams, J. S., Kugathasan, S., Huttenhower, C., Xavier, R. J. & Denson, L. A., Mar 1 2019, In : Mucosal Immunology. 12, 2, p. 491-502 12 p.

Research output: Contribution to journalArticle

alpha-Defensins
Dysbiosis
Defensins
Paneth Cells
Peyer's Patches

Blood-Derived DNA Methylation Signatures of Crohn's Disease and Severity of Intestinal Inflammation

Somineni, H. K., Venkateswaran, S., Kilaru, V., Marigorta, U. M., Mo, A., Okou, D. T., Kellermayer, R., Mondal, K., Cobb, D., Walters, T. D., Griffiths, A., Noe, J. D., Crandall, W. V., Rosh, J., Mack, D. R., Heyman, M. B., Baker, S. S., Stephens, M. C., Baldassano, R. N., Markowitz, J. F. & 9 othersDubinsky, M. C., Cho, J., Hyams, J. S., Denson, L. A., Gibson, G., Cutler, D. J., Conneely, K. N., Smith, A. K. & Kugathasan, S., Jun 1 2019, In : Gastroenterology. 156, 8, p. 2254-2265.e3

Research output: Contribution to journalArticle

Open Access
DNA Methylation
Inflammatory Bowel Diseases
Crohn Disease
Inflammation
Methylation

Clinical and biological predictors of response to standardised paediatric colitis therapy (PROTECT): a multicentre inception cohort study

Hyams, J. S., Davis Thomas, S., Gotman, N., Haberman, Y., Karns, R., Schirmer, M., Mo, A., Mack, D. R., Boyle, B., Griffiths, A. M., LeLeiko, N. S., Sauer, C. G., Keljo, D. J., Markowitz, J., Baker, S. S., Rosh, J., Baldassano, R. N., Patel, A., Pfefferkorn, M., Otley, A. & 30 othersHeyman, M., Noe, J., Oliva-Hemker, M., Rufo, P. A., Strople, J., Ziring, D., Guthery, S. L., Sudel, B., Benkov, K., Wali, P., Moulton, D., Evans, J., Kappelman, M. D., Marquis, M. A., Sylvester, F. A., Collins, M. H., Venkateswaran, S., Dubinsky, M., Tangpricha, V., Spada, K. L., Saul, B., Wang, J., Serrano, J., Hommel, K., Marigorta, U. M., Gibson, G., Xavier, R. J., Kugathasan, S., Walters, T. & Denson, L. A., Apr 27 2019, In : The Lancet. 393, 10182, p. 1708-1720 13 p.

Research output: Contribution to journalArticle

Colitis
Cohort Studies
Pediatrics
Mesalamine
Adrenal Cortex Hormones
1 Citation (Scopus)

Pediatric inflammatory bowel disease clinical innovations meeting of the Crohn's and colitis foundation: Charting the future of pediatric IBD

Picoraro, J. A., Lee, D., Heller, C. A., Weaver, A., Hyams, J. S., Conklin, L. S., Otley, A., Ziring, D., Kugathasan, S., Rosh, J., Mulberg, A., Denson, L. A., Kappelman, M. D., Grossman, A. B., Bousvaros, A. & Park, K. T., Jan 1 2019, In : Inflammatory bowel diseases. 25, 1, p. 27-32 6 p.

Research output: Contribution to journalArticle

Colitis
Inflammatory Bowel Diseases
Pediatrics
Research
Intestinal Diseases

The effects of concomitant immunomodulators on the pharmacokinetics, efficacy and safety of adalimumab in paediatric patients with Crohn’s disease: a post hoc analysis

Hyams, J. S., Dubinsky, M., Rosh, J., Ruemmele, F. M., Eichner, S. F., Maa, J. F., Lazar, A., Alperovich, G., Mostafa, N. M. & Robinson, A. M., Jan 1 2019, In : Alimentary Pharmacology and Therapeutics. 49, 2, p. 155-164 10 p.

Research output: Contribution to journalArticle

Immunologic Factors
Crohn Disease
Pharmacokinetics
Pediatrics
Safety
2 Citations (Scopus)

Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

Haberman, Y., Karns, R., Dexheimer, P. J., Schirmer, M., Somekh, J., Jurickova, I., Braun, T., Novak, E., Bauman, L., Collins, M. H., Mo, A., Rosen, M. J., Bonkowski, E., Gotman, N., Marquis, A., Nistel, M., Rufo, P. A., Baker, S. S., Sauer, C. G., Markowitz, J. & 22 othersPfefferkorn, M. D., Rosh, J., Boyle, B. M., Mack, D. R., Baldassano, R. N., Shah, S., Leleiko, N. S., Heyman, M. B., Grifiths, A. M., Patel, A. S., Noe, J. D., Aronow, B. J., Kugathasan, S., Walters, T. D., Gibson, G., Thomas, S. D., Mollen, K., Shen-Orr, S., Huttenhower, C., Xavier, R. J., Hyams, J. S. & Denson, L. A., Dec 1 2019, In : Nature Communications. 10, 1, 38.

Research output: Contribution to journalArticle

Open Access
Ulcerative Colitis
Transcriptome
genes
Genes
therapy
2018
4 Citations (Scopus)

The Effect of Early-Life Environmental Exposures on Disease Phenotype and Clinical Course of Crohn’s Disease in Children

Lindoso, L., Mondal, K., Venkateswaran, S., Somineni, H. K., Ballengee, C., Walters, T. D., Griffiths, A., Noe, J. D., Crandall, W., Snapper, S., Rabizadeh, S., Rosh, J., LeLeiko, N., Guthery, S., Mack, D., Kellermayer, R., Gulati, A. S., Pfefferkorn, M. D., Moulton, D. E., Keljo, D. & 17 othersCohen, S., Oliva-Hemker, M., Heyman, M. B., Otley, A., Baker, S. S., Evans, J. S., Kirschner, B. S., Patel, A. S., Ziring, D., Stephens, M. C., Baldassano, R., Dubinsky, M. C., Markowitz, J., Denson, L. A., Hyams, J., Kugathasan, S. & Ananthakrishnan, A. N., Oct 1 2018, In : American Journal of Gastroenterology. 113, 10, p. 1524-1529 6 p.

Research output: Contribution to journalArticle

Environmental Exposure
Crohn Disease
Phenotype
Hospitalization
Breast Feeding
2017
5 Citations (Scopus)

Subcutaneous Golimumab in Pediatric Ulcerative Colitis: Pharmacokinetics and Clinical Benefit

Hyams, J. S., Chan, D., Adedokun, O. J., Padgett, L., Turner, D., Griffiths, A., Veereman, G., Heyman, M. B., Rosh, J., Wahbeh, G. & Strauss, R., Dec 1 2017, In : Inflammatory bowel diseases. 23, 12, p. 2227-2237 11 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Ulcerative Colitis
Pediatrics
Weights and Measures
Tumor Necrosis Factor-alpha
2016

Preface. Clinical GI Challenges in the Adolescent

Rosh, J., Heitlinger, L. A. & Rosenfeld, W. D., Mar 1 2016, In : Adolescent medicine: state of the art reviews. 27, 1, p. xiii

Research output: Contribution to journalEditorial

Diet Fads
Eosinophilic Esophagitis
Adolescent Medicine
Vitamin D Deficiency
Celiac Disease
2015
22 Citations (Scopus)

Dissecting allele architecture of early onset IBD using high-density genotyping

Rabizadeh, S., Noe, J., Snapper, S., Otley, A., Cohen, S., Oliva-Hemker, M., Kirschner, B., Ashish, P., Ziring, D., Evans, J., Baker, S., Cutler, D. J., Zwick, M. E., Okou, D. T., Prahalad, S., Walters, T., Guthery, S. L., Dubinsky, M., Baldassano, R., Crandall, W. V. & 25 othersRosh, J., Markowitz, J., Stephens, M., Kellermayer, R., Pfefferkorn, M., Heyman, M. B., LeLeiko, N., Mack, D., Moulton, D., Kappelman, M. D., Kumar, A., Prince, J., Bose, P., Mondal, K., Ramachandran, D., Bohnsack, J. F., Griffiths, A. M., Haberman, Y., Essers, J., Thompson, S. D., Aronow, B., Keljo, D. J., Hyams, J. S., Denson, L. A. & Kugathasan, S., Jun 22 2015, In : PLoS ONE. 10, 6, e0128074.

Research output: Contribution to journalArticle

inflammatory bowel disease
Inflammatory Bowel Diseases
genotyping
Alleles
alleles
7 Citations (Scopus)

Erratum: Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature (Journal of Clinical Investigation (2014) 124: 8 (3617-3633) DOI: 10.1172/JCI75436)

Haberman, Y., Tickle, T. L., Dexheimer, P. J., Kim, M. O., Tang, D., Karns, R., Baldassano, R. N., Noe, J. D., Rosh, J., Markowitz, J., Heyman, M. B., Griffiths, A. M., Crandall, W. V., Mack, D. R., Baker, S. S., Huttenhower, C., Keljo, D. J., Hyams, J. S., Kugathasan, S., Walters, T. D. & 4 othersAronow, B., Xavier, R. J., Gevers, D. & Denson, L. A., Jan 1 2015, In : Journal of Clinical Investigation. 125, 3, 1 p.

Research output: Contribution to journalComment/debate

Microbiota
Transcriptome
Pediatric Crohn's disease
2010
19 Citations (Scopus)

Phase I trial of sargramostim in pediatric Crohn's disease

Kelsen, J. R., Rosh, J., Heyman, M., Winter, H. S., Ferry, G., Cohen, S., Mamula, P. & Baldassano, R. N., Jun 24 2010, In : Inflammatory bowel diseases. 16, 7, p. 1203-1208 6 p.

Research output: Contribution to journalArticle

Crohn Disease
Area Under Curve
Adrenal Cortex Hormones
Pharmacokinetics
Granulocytes
2008

(Pediatric Endocrinology Reviews (2007) 4, SUPPL. 3)

Kaplowitz, P., Geffner, M. E., Klein, K. O., Kasa-Vubu, J. Z., Daniels, M., Silverman, L., Lee, P. A., Walvoord, E. C. & Mazur, T., Mar 1 2008, In : Pediatric Endocrinology Reviews. 5, 3, 1 p.

Research output: Contribution to journalComment/debate

Endocrinology
Pediatrics
8 Citations (Scopus)

Predictors of first-year growth response to a fixed-dose growth hormone treatment in children born small for gestational age: Results of an open-label, multicenter trial in the United States

Rapaport, R., Saenger, P., Wajnrajch, M. P., Boston, B., Carakushansky, M., Chernausek, S., Clark, P., Cohen, J., Counts, D., Donohoue, P., Fuqua, J., Geffner, M., Harbison, M., Hardin, D., White, P., Kemp, S., Lee, P., Mauras, N., Neufeld, N., Oberfield, S. & 10 othersPlotnick, L., Reiter, E., Richards, G., Richton, S., Schultz, R., Silverman, L., Tollefsen, S., Wright, N., Yu, M. & Zipf, W., Jan 1 2008, In : Journal of Pediatric Endocrinology and Metabolism. 21, 5, p. 411-422 12 p.

Research output: Contribution to journalArticle

Growth Hormone
Gestational Age
Multicenter Studies
Growth
Therapeutics
2007

Pediatric Endocrinology Reviews: Foreword

Lee, P. A. & Silverman, L., Jun 1 2007, In : Pediatric Endocrinology Reviews. 4, SUPPL. 3, 1 p.

Research output: Contribution to journalEditorial

Endocrinology
Pediatrics
2005
265 Citations (Scopus)

A randomized, double-blind trial of lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's disease

Bousvaros, A., Guandalini, S., Baldassano, R. N., Botelho, C., Evans, J., Ferry, G. D., Goldin, B., Hartigan, L., Kugathasan, S., Levy, J., Murray, K. F., Oliva-Hemker, M., Rosh, J., Tolia, V., Zholudev, A., Vanderhoof, J. A. & Hibberd, P. L., Sep 1 2005, In : Inflammatory bowel diseases. 11, 9, p. 833-839 7 p.

Research output: Contribution to journalArticle

Lactobacillus rhamnosus
Crohn Disease
Placebos
Probiotics
Recurrence

Constipation: Can’t tether the symptoms to the diagnosis

Hirsch, B., Braegger, C., Bishop, W. P., Rosh, J., Lichtman, S. N. & Teitlebaum, J. E., Jan 1 2005, In : Journal of pediatric gastroenterology and nutrition. 40, 2

Research output: Contribution to journalArticle

2003
161 Citations (Scopus)

Update of guidelines for the use of growth hormone in children: The lawson wilkins pediatric endocrinology society drug and therapeutics committee

Wilson, T. A., Rose, S. R., Cohen, P., Rogol, A. D., Backeljauw, P., Brown, R., Hardin, D. S., Kemp, S. F., Lawson, M., Radovick, S., Rosenthal, S. M., Silverman, L. & Speiser, P., Jan 1 2003, In : Journal of Pediatrics. 143, 4, p. 415-421 7 p.

Research output: Contribution to journalArticle

Pharmacy and Therapeutics Committee
Endocrinology
Growth Hormone
Guidelines
Pediatrics
1995
53 Citations (Scopus)

Treatment of intractable gastrointestinal manifestations of chronic granulomatous disease with cyclosporine

Rosh, J., Tang, H. B., Mayer, L., Groisman, G., Abraham, S. K. & Prince, A., Jan 1 1995, In : The Journal of pediatrics. 126, 1, p. 143-145 3 p.

Research output: Contribution to journalArticle

Chronic Granulomatous Disease
Cyclosporine
Cytochromes b
Colitis
Inflammatory Bowel Diseases
1994
14 Citations (Scopus)

Primary immunization status in infants referred for liver transplantation

Thall, T. V., Rosh, J., Schwersenz, A. H., Eickmeyer, D., Fernandez, M., Benkov, K. J. & LeLeiko, N. S., Jan 1 1994, In : Transplantation Proceedings. 26, 1, 1 p.

Research output: Contribution to journalArticle

Immunization Schedule
Biliary Atresia
Liver Failure
Preschool Children
Infection Control
100 Citations (Scopus)

Supracondylar humerus fractures: Current trends and controversies

Minkowitz, B. & Busch, M. T., Jan 1 1994, In : Orthopedic Clinics of North America. 25, 4, p. 581-594 14 p.

Research output: Contribution to journalReview article

Humerus
Biomechanical Phenomena
Physicians
Bone and Bones
Wounds and Injuries
1992

In Memorium to Dr. Toor

Rosh, J., Kurfist, L., Benkov, K., Bottone, E. & LeLeiko, N., Jan 1 1992, In : The American Journal of Gastroenterology. 87, 3, p. 406 1 p.

Research output: Contribution to journalLetter